Info: Read More
  • 中药标准品生产商,产品定制服务
  • 苦楝萜酸甲酯

    Methyl kulonate

    苦楝萜酸甲酯
    产品编号 CFN92975
    CAS编号 22611-37-6
    分子式 = 分子量 C31H48O4 = 484.71
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The seeds of Melia toosendan
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    苦楝萜酸甲酯 CFN92975 22611-37-6 1mg QQ客服:2056216494
    苦楝萜酸甲酯 CFN92975 22611-37-6 5mg QQ客服:2056216494
    苦楝萜酸甲酯 CFN92975 22611-37-6 10mg QQ客服:2056216494
    苦楝萜酸甲酯 CFN92975 22611-37-6 20mg QQ客服:2056216494
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Hertfordshire (United Kingdom)
  • University of Wuerzburg (Germany)
  • University of Lodz (Poland)
  • University of South Australia (Australia)
  • Julius Kühn-Institut (Germany)
  • University of Zurich (Switzerland)
  • University of Minnesota (USA)
  • Rio de Janeiro State University (Brazil)
  • Shanghai University of TCM (China)
  • University of Madras (India)
  • Institute of Chinese Materia Medica (China)
  • University of the Basque Country (Spain)
  • Sant Gadge Baba Amravati University (India)
  • Utah State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2022, 27(19):6681.
  • RSC Adv.2018, 32621-32636
  • Appl. Sci.2021, 11(1),14.
  • Pharmaceuticals (Basel).2020, 13(9):262.
  • Phytomedicine.2021, 93:153789.
  • Front Immunol. 2020, 11:62.
  • Molecules.2016, 21(6)
  • National Academy Science Letters2023, s40009.
  • J Pharm Biomed Anal.2016, 129:50-59
  • J Nat Prod.2015, 78(6):1339-4
  • J Ethnopharmacol.2020, 269:113752.
  • PLoS One.2017, 12(8):e0181191
  • Molecules.2021, 26(23):7390.
  • Sci Rep.2020, 10:4495(2020)
  • Mol Neurobiol.2022, 02873-9.
  • Nat Commun.2021, 12(1):681.
  • Neuropharmacology2019, 151437
  • Evid Based Complement Alternat Med.2021, 2021:6687513.
  • Molecules.2023, 28(8):3414.
  • Food Funct.2022, 13(14):7638-7649.
  • Chemistry of Plant Materials.2019, 215-222
  • Kor. J. Herbol.2019, 34(2):59-66
  • Recent Pat Anticancer Drug Discov.2022, 17(4):416-426.
  • ...
  • 生物活性
    Description: Methyl kulonate shows interesting antimycobacterial activity (with MIC value of 70 uM ). Methyl kulonate exhibits potent cytotoxicities against HL60 cells with IC50 values in the range of 2.8-5.8 uM.It inhibits production of nitric oxide (NO) in mouse macrophage RAW 264.7 cells induced by lipopolysaccharide (LPS).
    Targets: NO | NOS | COX | Antifection
    In vitro:
    PLoS One. 2015 Oct 20;10(10):e0141272.
    Limonoids from Melia azedarach Fruits as Inhibitors of Flaviviruses and Mycobacterium tubercolosis.[Pubmed: 26485025]
    The biological diversity of nature is the source of a wide range of bioactive molecules. The natural products, either as pure compounds or as standardized plant extracts, have been a successful source of inspiration for the development of new drugs. The present work was carried out to investigate the cytotoxicity, antiviral and antimycobacterial activity of the methanol extract and of four identified limonoids from the fruits of Melia azedarach (Meliaceae).
    METHODS AND RESULTS:
    The extract and purified limonoids were tested in cell-based assays for antiviral activity against representatives of ssRNA, dsRNA and dsDNA viruses and against Mycobacterium tuberculosis. Very interestingly, 3-α-tigloyl-melianol and melianone showed a potent antiviral activity (EC50 in the range of 3-11μM) against three important human pathogens, belonging to Flaviviridae family, West Nile virus, Dengue virus and Yellow Fever virus. Mode of action studies demonstrated that title compounds were inhibitors of West Nile virus only when added during the infection, acting as inhibitors of the entry or of a very early event of life cycle. Furthermore, 3-α-tigloyl-melianol and Methyl kulonate showed interesting antimycobacterial activity (with MIC values of 29 and 70 μM respectively). The limonoids are typically lipophilic compounds present in the fruits of Melia azeradach. They are known as cytotoxic compounds against different cancer cell lines, while their potential as antiviral and antibacterial was poorly investigated.
    CONCLUSIONS:
    Our studies show that they may serve as a good starting point for the development of novel drugs for the treatment of infections by Flaviviruses and Mycobacterium tuberculosis, for which there is a continued need.
    Chem Biodivers. 2014 Aug;11(8):1121-39.
    Cytotoxic and nitric oxide production-inhibitory activities of limonoids and other compounds from the leaves and bark of Melia azedarach.[Pubmed: 25146759 ]
    Nine limonoids, 1-9, one apocarotenoid, 11, one alkaloid, 12, and one steroid, 13, from the leaf extract; and one triterpenoid, 10, five steroids, 14-18, and two flavonoids, 19 and 20, from the bark extract of Melia azedarach L. (Chinaberry tree; Meliaceae) were isolated.
    METHODS AND RESULTS:
    Among these compounds, three compounds, 4-6, were new, and their structures were established as 3-deacetyl-28-oxosalannolactone, 3-deacetyl-28-oxosalanninolide, and 3-deacetyl-17-defurano-17,28-dioxosalannin, respectively, on the basis of extensive spectroscopic analyses and comparison with literature data. All of the isolated compounds were evaluated for their cytotoxic activities against leukemia (HL60), lung (A549), stomach (AZ521), and breast (SK-BR-3) cancer cell lines. 3-Deacetyl-4'-demethyl-28-oxosalannin (3) against HL60 and AZ521 cells, and Methyl kulonate (10) against HL60 cells exhibited potent cytotoxicities with IC50 values in the range of 2.8-5.8 μM. In addition, upon evaluation of compounds 1-13 against production of nitric oxide (NO) in mouse macrophage RAW 264.7 cells induced by lipopolysaccharide (LPS), seven, i.e., trichilinin B (1), 4, ohchinin (7), 23-hydroxyohchininolide (8), 21-hydroxyisoohchininolide (9), 10, and methyl indole 3-carboxylate (12), inhibited production of NO with IC50 values in the range of 4.6-87.3 μM with no, or almost no, toxicity to the cells (IC50 93.2-100 μM).
    CONCLUSIONS:
    Western blot analysis revealed that compound 7 reduced the expression levels of the inducible NO synthase (iNOS) and COX-2 proteins in a concentration-dependent manner. Furthermore, compounds 5, 6, 13, and 18-20 exhibited potent inhibitory effects (IC50 299-381 molar ratio/32 pmol TPA) against Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cell line.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0631 mL 10.3154 mL 20.6309 mL 41.2618 mL 51.5772 mL
    5 mM 0.4126 mL 2.0631 mL 4.1262 mL 8.2524 mL 10.3154 mL
    10 mM 0.2063 mL 1.0315 mL 2.0631 mL 4.1262 mL 5.1577 mL
    50 mM 0.0413 mL 0.2063 mL 0.4126 mL 0.8252 mL 1.0315 mL
    100 mM 0.0206 mL 0.1032 mL 0.2063 mL 0.4126 mL 0.5158 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    桦褐孔菌醇; Inotodiol CFN92367 35963-37-2 C30H50O2 = 442.7 5mg QQ客服:2159513211
    3beta-羟基羊毛甾-8,24-二烯-21-醛; 3beta-Hydroxylanosta-8,24-diene-21-al CFN92365 96574-03-7 C30H48O2 = 440.7 5mg QQ客服:1457312923
    3β-羟基-羊毛甾-8,24-二烯-21-酸; Trametenolic acid CFN92366 24160-36-9 C30H48O3 = 456.7 10mg QQ客服:1457312923
    Tsugaric acid A; Tsugaric acid A CFN90990 174391-64-1 C32H50O4 = 498.8 5mg QQ客服:1413575084
    榄香酮酸; Beta-Elemonic acid CFN90991 28282-25-9 C30H46O3 = 454.7 20mg QQ客服:1413575084
    16 alpha-Hydroxytrametenolic acid; 16 alpha-Hydroxytrametenolic acid CFN90803 176390-68-4 C30H48O4 = 472.7 5mg QQ客服:1413575084
    3-O-Acetyl-16 alpha-hydroxytrametenolic acid; 3-O-Acetyl-16 alpha-hydroxytrametenolic acid CFN90804 168293-13-8 C32H50O5 = 514.8 5mg QQ客服:215959384
    松苓新酸; Dehydrotrametenolic acid CFN90577 29220-16-4 C30H46O3 = 454.69 20mg QQ客服:1457312923
    16α-羟基松苓新酸; 16alpha-Hydroxydehydrotrametenolic acid CFN90790 176390-66-2 C30H46O4 = 470.7 5mg QQ客服:1457312923
    3-O-乙酰基-16α-羟基松苓新酸; 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid CFN90791 168293-14-9 C32H48O5 = 512.7 5mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产