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  • 地黄苷

    Martynoside

    地黄苷
    产品编号 CFN97159
    CAS编号 67884-12-2
    分子式 = 分子量 C31H40O15 = 652.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The herbs of Plantago asiatica L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    地黄苷 CFN97159 67884-12-2 1mg QQ客服:1457312923
    地黄苷 CFN97159 67884-12-2 5mg QQ客服:1457312923
    地黄苷 CFN97159 67884-12-2 10mg QQ客服:1457312923
    地黄苷 CFN97159 67884-12-2 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Federal de Goias (UFG) (Brazil)
  • Subang Jaya Medical Centre (Malaysia)
  • Wroclaw Medical University (Poland)
  • Universidade Católica Portuguesa (Portugal)
  • Osmania University (India)
  • Aarhus University (Denmark)
  • Texas A&M University (USA)
  • Universidade da Beira Interior (Germany)
  • The University of Newcastle (Australia)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • University of Wuerzburg (Germany)
  • University of Limpopo (South Africa)
  • Colorado State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • Int J Mol Sci.2020, 21(6):2190.
  • Korean Journal of Medicinal Crop Science2018, 26(5):382-390
  • Dicle Tip Dergisi2020, 47(2),423-430.
  • Front Pharmacol.2021, 12:652860.
  • J Control Release.2021, 336:159-168.
  • Korean J. Medicinal Crop Sci2021, 10:345-352.
  • Molecules.2020, 25(9):2081.
  • Neuropharmacology.2018, 131:68-82
  • Metabolites.2020, 11(1):E11.
  • Int J Cosmet Sci.2022, doi:10.1111/ics.12827.
  • Industrial Crops and Products2019, 140:111612
  • Korean J of Crop Science2019, 452-458
  • Comput Biol Chem.2019, 83:107096
  • Journal of Ginseng Research2021, 25 November
  • J Pharmaceutical and Biomedical Analysis2022, 114631.
  • Chung Shan Medical University2020, US20200323790A1
  • Front Plant Sci.2022, 13: 905275.
  • Acta Physiologiae Plantarum2016, 38:7
  • Drug Chem Toxicol.2020, 1-14.
  • Org Biomol Chem.2017, 15(31):6483-6492
  • Int J Mol Sci.2019, 20(16):E4015
  • Plant Direct.2021, 5(12):e372.
  • ...
  • 生物活性
    Description: Martynoside is a natural selective estrogen receptor modulator, which has antioxidative, anti-muscle fatigue, anticancer and antimetastatic activities. Martynoside has the potential of antagonizing sports anaemia, the mechanism of this effect might be related to preventing RBC from free radical damage.
    Targets: Estrogen receptor | ROS | Progestogen receptor
    In vitro:
    Free Radic Res. 2003 Aug;37(8):829-33.
    Antioxidative properties of Martynoside: pulse radiolysis and laser photolysis study.[Pubmed: 14567442]

    METHODS AND RESULTS:
    Free radical reactions of Martynoside (MAR), a phenylpropanoid glycoside, with a variety of oxidants were studied in the aqueous solution by laser photolysis and pulse radiolysis techniques. The pKa value of Martynoside in aqueous solution was measured from the pH dependent changes of the UV absorption at 384 nm with value of pKa = 9.2. The phenoxyl radical of Martynoside which exhibits maximum absorption at 360 nm was generated by one-electron transfer to N3* or Br2*-. Other important properties of phenoxyl radical such as extinction coefficient, formation and decay rate constants were also determined.
    CONCLUSIONS:
    The reaction rate constant of O2*- with Martynoside , k = 8.5 x 10(4) dm3 x mol(-1) x s(-1), was measured by the method of competition kinetics. By measuring time-resolved luminescence emission at 1270 nm, the quenching rate constant of singlet oxygen by MAR was obtained to be 3.3 x 10(6) dm3 x mol(-1) x s(-1). Reduction potential of the Martynoside couple (MAR*/MAR), determined using rutin as reference compound, gave a value E = 0.66 V vs. NHE. The antioxidative properties of Martynoside were compared with those of some well-known antioxidants.
    Phytother Res. 1999 Nov;13(7):621-3.
    Retardation of skeletal muscle fatigue by the two phenylpropanoid glycosides: verbascoside and martynoside from Pedicularis plicata maxim.[Pubmed: 10548760]

    METHODS AND RESULTS:
    The effects of the phenylpropanoid glycosides verbascoside and Martynoside from Pedicularis plicata were investigated on muscle contractility in Bufo gastrocnemius muscle electrically stimulated in vitro. The maximum amplitude and maintained time of contraction were mechanically recorded and used as indices of muscle contractility. After 30 min pretreatment of the muscle, verbascoside at 20.0 microM resisted muscle fatigue significantly while Martynoside at 80.0 microM improved muscle contractility only slightly.
    CONCLUSIONS:
    These two glycosides resisted muscle fatigue depending on their antioxidative activities, which is in agreement with the role of reactive oxygen species (ROS) in promoting fatigue in skeletal muscle.
    In vivo:
    Int J Sports Med. 2010 Aug;31(8):537-41.
    Anti-sports anaemia effects of verbascoside and martynoside in mice.[Pubmed: 20556696 ]
    This paper aims to investigate the effects of verbascoside and Martynoside isolated from PEDICULARIS DOLICHOCYMBA on sports anaemia.
    METHODS AND RESULTS:
    Forty mice were divided into four groups: Group R (control group, nonsupplemented and maintained at rest), Group E (nonsupplemented and undergoing exercise), Group VE (supplemented with verbascoside 10 mg/kg per day and undergoing exercise), and Group ME (supplemented with Martynoside 10 mg/kg per day and undergoing exercise). After 5 weeks intensive swimming exercises, we measured the RBC count, the hemoglobin concentration, the hematocrit (Hct), the mean corpuscular hemoglobin concentration (MCHC) and the mean corpuscular hemoglobin (MCH). We studied the shapes of RBC and measured the plasma malonyldialdehyde (MDA). We found Group E showed lower RBC, hemoglobin and Hct levels, higher MCHC, MCH, plasma MDA levels and the abnormally shaped RBCs percentage than Groups R, VE and ME. Group ME showed lower RBC and Hct levels, higher MCH, plasma MDA levels and the abnormally shaped RBCs percentage than Group VE.
    CONCLUSIONS:
    The results indicated that verbascoside and Martynoside have the potential of antagonizing sports anaemia, the mechanism of this effect might be related to preventing RBC from free radical damage. Moreover, verbascoside was found to be more active than Martynoside.
    Biomed Pharmacother . 2021 Jun;138:111501.
    Ex vivo and in vivo chemoprotective activity and potential mechanism of Martynoside against 5-fluorouracil-induced bone marrow cytotoxicity[Pubmed: 33765584]
    Abstract Martynoside (MAR) is a bioactive glycoside of Rehmannia glutinosa, a traditional Chinese herb frequently prescribed for treating chemotherapy-induced pancytopenia. Despite its clinical usage in China for thousands of years, the mechanism of MAR's hematopoietic activity and its impact on chemotherapy-induced antitumor activity are still unclear. Here, we showed that MAR protected ex vivo bone marrow cells from 5-fluorouracil (5-FU)-induced cell death and inflammation response by down-regulating the TNF signaling pathway, in which II1b was the most regulatory gene. Besides, using mouse models with melanoma and colon cancer, we further demonstrated that MAR had protective effects against 5-FU-induced myelosuppression in mice without compromising its antitumor activity. Our results showed that MAR increased the number of bone marrow nucleated cells (BMNCs) and the percentage of leukocyte and granulocytic populations in 5-FU-induced myelosuppressive mice, accompanied by an increase in numbers of circulating white blood cells and platelets. The transcriptome profile of BMNCs further showed that the mode of action of MAR might be associated with the increased survival of BMNCs and the improvement of the bone marrow microenvironment. In summary, we revealed the potential molecular mechanism of MAR to counteract 5-FU-induced bone marrow cytotoxicity both ex vivo and in vivo, and highlighted its potential clinical usage in cancer patients experiencing chemotherapy-induced multi-lineage myelosuppression. Keywords: 5-fluorouracil; Bone marrow cytotoxicity; Chemoprotective activity; Martynoside; mRNA-Seq.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5321 mL 7.6605 mL 15.321 mL 30.6419 mL 38.3024 mL
    5 mM 0.3064 mL 1.5321 mL 3.0642 mL 6.1284 mL 7.6605 mL
    10 mM 0.1532 mL 0.766 mL 1.5321 mL 3.0642 mL 3.8302 mL
    50 mM 0.0306 mL 0.1532 mL 0.3064 mL 0.6128 mL 0.766 mL
    100 mM 0.0153 mL 0.0766 mL 0.1532 mL 0.3064 mL 0.383 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    毛蕊花糖苷; 麦角甾苷; Acteoside CFN97048 61276-17-3 C29H36O15 = 624.6 20mg QQ客服:1457312923
    2'-乙酰基毛蕊花糖苷; 2'-Acetylacteoside CFN92452 94492-24-7 C31H38O16 = 666.6 20mg QQ客服:3257982914
    异麦角甾苷; Isoacteoside CFN97049 61303-13-7 C29H36O15 = 624.6 20mg QQ客服:3257982914
    紫葳新苷II; Campneoside II CFN95498 95587-86-3 C29H36O16 = 640.6 10mg QQ客服:1457312923
    beta-羟基麦角甾苷; beta-Hydroxyacteoside CFN95499 109279-13-2 C29H36O16 = 640.6 10mg QQ客服:2159513211
    beta-氧化毛蕊花糖苷; beta-Oxoacteoside CFN95667 149507-92-6 C29H34O16 = 638.6 5mg QQ客服:3257982914
    厚朴苷D; Magnoloside D CFN91910 1418309-03-1 C29H36O15 = 624.59 5mg QQ客服:1457312923
    Leucosceptoside A; Leucosceptoside A CFN89166 83529-62-8 C30H38O15 = 638.61 5mg QQ客服:1457312923
    地黄苷; Martynoside CFN97159 67884-12-2 C31H40O15 = 652.7 5mg QQ客服:215959384
    异地黄苷; Isomartynoside CFN97525 94410-22-7 C31H40O15 = 652.7 5mg QQ客服:3257982914

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