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  • 木兰脂素

    Magnolin

    木兰脂素
    产品编号 CFN98391
    CAS编号 31008-18-1
    分子式 = 分子量 C23H28O7 = 416.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The flowers of Magnolia biondii Pamp.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    木兰脂素 CFN98391 31008-18-1 10mg QQ客服:2159513211
    木兰脂素 CFN98391 31008-18-1 20mg QQ客服:2159513211
    木兰脂素 CFN98391 31008-18-1 50mg QQ客服:2159513211
    木兰脂素 CFN98391 31008-18-1 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Sao Paulo (Brazil)
  • Institute of Chinese Materia Medica (China)
  • CSIRO - Agriculture Flagship (Australia)
  • Universidad Miguel Hernández (Spain)
  • Indian Institute of Science (India)
  • Anna University (India)
  • University of Toulouse (France)
  • University Medical Center Mainz (Germany)
  • Tokyo Woman's Christian University (Japan)
  • Seoul National University of Science and Technology (Korea)
  • Charles University in Prague (Czech Republic)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • FORTH-IMBB (Greece)
  • Washington State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean Journal of Pharmacognosy2018, 49(3):270-277
  • Indian J Pharm Sci.2022, 84(4): 874-882.
  • Molecules.2018, 23(3):E615
  • Pharmaceuticals (Basel).2021, 14(3):260.
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • Phytochemistry.2021, 181:112539.
  • Mol Pharmacol.2021, 99(2):163-174.
  • Curr Issues Mol Biol.2022, 44(10):5106-5116.
  • Int J Mol Med.2020, 45(5):1514-1524.
  • Int J Mol Sci.2021, 22(12):6466.
  • Molecules.2016, 21(6)
  • Life Sci.2022, 311(Pt A):121157.
  • BMC Plant Biol.2021, 21(1):60.
  • Microbiol. Biotechnol. Lett.2022, 50(2): 193-201.
  • Pest Manag Sci.2019, 75(9):2530-2541
  • The Japan Society for Analytical Chemistry2017, 613-617
  • Foods.2022, 11(12):1773.
  • Pharmaceutics.2021, 13(2):187.
  • Food Sci Biotechnol.2021, 30(2):217-226.
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Nutr Res Pract.2020, 14(5):478-489.
  • Key Engineering Materials2022, 931(47-53).
  • J Med Food.2019, 22(10):1067-1077
  • ...
  • 生物活性
    Description: Magnolin has anti-inflammatory, anti-histaminic, and antioxidative effects, it might be a naturally occurring chemoprevention and therapeutic agent capable of inhibiting cell proliferation and transformation by targeting ERK1 and ERK2. Magnolin can ameliorate the renal tubular necrosis, apoptosis, and the deterioration of renal function, it reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro.
    Targets: Caspase | ERK | EGFR | Serine kinase | P450 (e.g. CYP17) | Threonin kinase
    In vitro:
    Xenobiotica. 2011 May;41(5):358-71.
    In vitro metabolism of magnolin and characterization of cytochrome P450 enzymes responsible for its metabolism in human liver microsomes.[Pubmed: 21294626]
    Magnolin is a major bioactive component found in Shin-i, the dried flower buds of Magnolia fargesii; it has anti-inflammatory and anti-histaminic activities. Incubation of magnolin in human liver microsomes with an nicotinamide adenine dinucleotide phosphate-generating system resulted in the formation of five metabolites, namely, O-desmethyl magnolin (M1 and M2), didesmethylmagnolin (M3), and hydroxymagnolin (M4 and M5).
    METHODS AND RESULTS:
    In this study, we characterized the human liver cytochrome P450 (CYP) enzymes responsible for the biotransformation of three major metabolites--M1, M2, and M4--of magnolin. CYP2C8, CYP2C9, CYP2C19, and CYP3A4 were identified as the major enzymes responsible for the formation of the two O-desmethyl magnolins (M1 and M2), on the basis of a combination of correlation analysis and experiments, including immunoinhibition of magnolin in human liver microsomes and metabolism of magnolin by human cDNA-expressed CYP enzymes. CYP2C8 played a predominant role in the formation of hydroxymagnolin (M4).
    CONCLUSIONS:
    These results suggest that the pharmacokinetics of magnolin may not be affected by CYP2C8, CYP2C9, CYP2C19, and CYP3A4 responsible for the metabolism of magnolin or by the co-administration of appropriate CYP2C8, CYP2C9, CYP2C19, and CYP3A4 inhibitors or inducers due to the involvement of multiple CYP enzymes in the metabolism of magnolin.
    BMC Cancer . 2015 Aug 8;15:576.
    Magnolin inhibits cell migration and invasion by targeting the ERKs/RSK2 signaling pathway[Pubmed: 26253302]
    Abstract Background: Magnolin is a natural compound abundantly found in Magnolia flos, which has been traditionally used in oriental medicine to treat headaches, nasal congestion and anti-inflammatory reactions. Our recent results have demonstrated that magnolin targets the active pockets of ERK1 and ERK2, which are important signaling molecules in cancer cell metastasis. The aim of this study is to evaluate the effects of magnolin on cell migration and to further explore the molecular mechanisms involved. Methods: Magnolin-mediated signaling inhibition was confirmed by Western blotting using RSK2(+/+) and RSK2(-/-) MEFs, A549 and NCI-H1975 lung cancer cells, and by NF-κB and Cox-2 promoter luciferase reporter assays. Inhibition of cell migration by magnolin was examined by wound healing and/or Boyden Chamber assays using JB6 Cl41 and A549 human lung cancer cells. The molecular mechanisms involved in cell migration and epithelial-to-mesenchymal transition were determined by zymography, Western blotting, real-time PCR and immunocytofluorescence. Results: Magnolin inhibited NF-κB transactivation activity by suppressing the ERKs/RSK2 signaling pathway. Moreover, magnolin abrogated the increase in EGF-induced COX-2 protein levels and wound healing. In human lung cancer cells such as A549 and NCI-H1975, which harbor constitutive active Ras and EGFR mutants, respectively, magnolin suppressed wound healing and cell invasion as seen by a Boyden chamber assay. In addition, it was observed that magnolin inhibited MMP-2 and -9 gene expression and activity. The knockdown or knockout of RSK2 in A549 lung cancer cells or MEFs revealed that magnolin targeting ERKs/RSK2 signaling suppressed epithelial-to-mesenchymal transition by modulating EMT marker proteins such as N-cadherin, E-cadherin, Snail, Vimentin and MMPs. Conclusions: These results demonstrate that magnolin inhibits cell migration and invasion by targeting the ERKs/RSK2 signaling pathway.
    In vivo:
    Oxid Med Cell Longev. 2014;2014:203458.
    Magnolin protects against contrast-induced nephropathy in rats via antioxidation and antiapoptosis.[Pubmed: 25400863]
    Magnolin is the major active ingredient of the herb Magnolia fargesii which has anti-inflammatory and antioxidative effects. Oxidative stress and apoptosis are involved in the pathogenesis of contrast-induced nephropathy (CIN). We hypothesize that Magnolin could protect against CIN through antioxidative and antiapoptotic properties.
    METHODS AND RESULTS:
    To test whether Magnolin could attenuate CIN, oxidative stress and apoptosis, in vivo and in vitro, we utilized a rat model of ioversol-induced CIN and a cell model of oxidative stress in which HK2 cells were treated with H2O2. Rats were assigned to 4 groups (n = 6 per group): control group, ioversol group (ioversol-induced CIN), vehicle group (CIN rats pretreated with vehicle), and Magnolin group (CIN rats pretreated with 1 mg/kg Magnolin). The results showed that magnolin ameliorated the renal tubular necrosis, apoptosis, and the deterioration of renal function (P < 0.05). Furthermore, Magnolin reduced the renal oxidative stress, suppressed caspase-3 activity, and increased Bcl-2 expression in vivo and in vitro.
    CONCLUSIONS:
    Magnolin might protect CIN in rats through antioxidation and antiapoptosis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.401 mL 12.0048 mL 24.0096 mL 48.0192 mL 60.024 mL
    5 mM 0.4802 mL 2.401 mL 4.8019 mL 9.6038 mL 12.0048 mL
    10 mM 0.2401 mL 1.2005 mL 2.401 mL 4.8019 mL 6.0024 mL
    50 mM 0.048 mL 0.2401 mL 0.4802 mL 0.9604 mL 1.2005 mL
    100 mM 0.024 mL 0.12 mL 0.2401 mL 0.4802 mL 0.6002 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    梣皮树脂醇; Medioresinol CFN98641 40957-99-1 C21H24O7 = 388.4 5mg QQ客服:1413575084
    木兰脂素; Magnolin CFN98391 31008-18-1 C23H28O7 = 416.5 20mg QQ客服:2056216494
    表木兰脂素A; Epimagnolin A CFN90949 41689-51-4 C23H28O7 = 416.46 10mg QQ客服:215959384
    Epiaschantin; Epiaschantin CFN96901 41689-50-3 C22H24O7 = 400.42 5mg QQ客服:2159513211
    蒿脂麻木质体; Sesartemin CFN97907 77394-27-5 C23H26O8 = 430.5 5mg QQ客服:2056216494
    Episesartemin A ; Episesartemin A CFN96936 77449-31-1 C23H26O8 = 430.45 5mg QQ客服:215959384
    1-羟基松脂酚 1-O-beta-D-葡糖苷 ; 1-Hydroxypinoresinol 1-O-glucoside CFN96713 81495-71-8 C26H32O12 = 536.53 5mg QQ客服:1413575084
    Fraxiresinol 1-O-glucoside; Fraxiresinol 1-O-glucoside CFN97460 89199-94-0 C27H34O13 = 566.6 5mg QQ客服:2159513211
    异戊烯基辣薄荷醇; Prenylpiperitol CFN99668 157659-20-6 C25H28O6 = 424.5 5mg QQ客服:215959384
    Planispine A; Planispine A CFN95348 1202761-42-9 C26H32O6 = 440.5 10mg QQ客服:3257982914

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