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  • 10-甲氧基-8,8-二甲基-2H,8H-苯并[1,2-b:5,4-b']二吡喃-2-酮

    Luvangetin

    10-甲氧基-8,8-二甲基-2H,8H-苯并[1,2-b:5,4-b']二吡喃-2-酮
    产品编号 CFN89243
    CAS编号 483-92-1
    分子式 = 分子量 C15H14O4 = 258.27
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The seeds of Aegle marmelos Correa.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    10-甲氧基-8,8-二甲基-2H,8H-苯并[1,2-b:5,4-b']二吡喃-2-酮 CFN89243 483-92-1 1mg QQ客服:2056216494
    10-甲氧基-8,8-二甲基-2H,8H-苯并[1,2-b:5,4-b']二吡喃-2-酮 CFN89243 483-92-1 5mg QQ客服:2056216494
    10-甲氧基-8,8-二甲基-2H,8H-苯并[1,2-b:5,4-b']二吡喃-2-酮 CFN89243 483-92-1 10mg QQ客服:2056216494
    10-甲氧基-8,8-二甲基-2H,8H-苯并[1,2-b:5,4-b']二吡喃-2-酮 CFN89243 483-92-1 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Malaya (Malaysia)
  • National Hellenic Research Foundation (Greece)
  • Aarhus University (Denmark)
  • Universidad de La Salle (Mexico)
  • Anna University (India)
  • Wageningen University (Netherlands)
  • The Institute of Cancer Research (United Kingdom)
  • Kitasato University (Japan)
  • Heidelberg University (Germany)
  • University of Pretoria (South Africa)
  • Korea Food Research Institute(KFRI) (Korea)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • University of Fribourg (Switzerland)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int. J. Mol. Sci.2022, 23(19), 11900.
  • J Pharm Biomed Anal.2019, 164:119-127
  • Nutr Res Pract.2020, 14(3):203-217.
  • Oncol Rep.2019, 41(4):2453-2463
  • Phytomedicine.2017, 24:77-86
  • Int J Mol Sci.2015, 16(8):18396-411
  • Sustainability2021, 13(23),12981.
  • Ecol Evol.2022, 12(11):e9459.
  • JMSACL2023, 09.002
  • Molecules.2018, 23(9):E2121
  • Phytomedicine.2021, 84:153501.
  • Phytomedicine.2019, 62:152962
  • Food Chem.2020, 327:126992.
  • Foods2023, 12(23), 4342.
  • J Ethnopharmacol.2019, 228:132-141
  • Food Chem.2019, 278:683-691
  • Phytomedicine.2019, 67:153159
  • Chemistr of plant2016, 2016021195
  • Current Topics in Nutraceutical Research2021, 19(1),p90-105.
  • Appl. Sci. 2021, 11(22),10569
  • Gene.2022, 815:146178.
  • Plants (Basel).2020, 9(11):1555.
  • Sci Rep.2018, 8(1):12970
  • ...
  • 生物活性
    Description: Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection against pylorus-ligated and aspirin-induced gastric ulcers in rats and cold restraint stress-induced gastric ulcers in rats and guinea pigs.
    Targets: NO | PGE | COX | Antifection
    In vitro:
    Pharm Biol. 2017 Dec;55(1):1195-1201.
    Anti-inflammatory coumarins from Paramignya trimera.[Pubmed: 28245363 ]

    METHODS AND RESULTS:
    Seven coumarins were isolated and identified as: ostruthin (1), ninhvanin (2), 8-geranyl-7-hydroxycoumarin (3), 6-(6',7'-dihydroxy-3',7'-dimethylocta-2'-enyl)-7-hydroxycoumarin (4), 6-(7-hydroperoxy-3,7-dimethylocta-2,5-dienyl)-7-hydroxycoumarin (5), 6-(2-hydroxyethyl)-2,2-dimethyl-2H-1-benzopyran (6), and Luvangetin (7). Compounds 1-4 and 7 inhibited NO and PGE2 production in LPS-stimulated BV2 cells, with IC50 values ranging from 9.8 to 46.8 and from 9.4 to 52.8 μM, respectively. Ostruthin (1) and ninhvanin (2) were shown to suppress LPS-induced iNOS and COX-2 protein expression.
    CONCLUSIONS:
    The present study provides a scientific rationale for the use of P. trimera in the prevention and treatment of neuroinflammatory diseases. Ostruthin and ninhvanin might have potential therapeutic effects and should be considered for further development as new anti-neuroinflammatory agents.
    In vivo:
    Indian J Exp Biol. 1997 Oct;35(10):1080-3.
    Antiulcer activity of naturally occurring pyrano-coumarin and isocoumarins and their effect on prostanoid synthesis using human colonic mucosa.[Pubmed: 9475044]

    METHODS AND RESULTS:
    Oral administration of bergenin and norbergenin, two isocoumarins, isolated from the leaves and roots of Flueggea microcarpa and Luvangetin, a pyranocoumarin isolated from the seeds of Aegle marmelos Correa, showed significant protection against pylorus-ligated and aspirin-induced gastric ulcers in rats and cold restraint stress-induced gastric ulcers in rats and guinea pigs. The study on prostaglandins release by human colonic mucosal incubates, indicated a concentration-dependent (1-10 micrograms/ml) stimulatory effect of bergenin and norbergenin, while Luvangetin (1-10 micrograms/ml) did not produce any effect.
    CONCLUSIONS:
    The results suggest that gastroprotective effects of bergenin and norbergenin could be due to increased prostaglandin production while, some other mucosal defensive factors may be involved for Luvangetin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.8719 mL 19.3596 mL 38.7192 mL 77.4383 mL 96.7979 mL
    5 mM 0.7744 mL 3.8719 mL 7.7438 mL 15.4877 mL 19.3596 mL
    10 mM 0.3872 mL 1.936 mL 3.8719 mL 7.7438 mL 9.6798 mL
    50 mM 0.0774 mL 0.3872 mL 0.7744 mL 1.5488 mL 1.936 mL
    100 mM 0.0387 mL 0.1936 mL 0.3872 mL 0.7744 mL 0.968 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    小芸木素; Micromelin CFN99629 15085-71-9 C15H12O6 = 288.3 5mg QQ客服:2159513211
    Hydramicromelin B; Hydramicromelin B CFN89277 369391-55-9 C15H14O7 = 306.27 5mg QQ客服:2159513211
    Hydramicromelin D; Hydramicromelin D CFN89265 1623437-86-4 C15H14O7 = 306.27 5mg QQ客服:3257982914
    花椒树皮素甲; Xanthyletin CFN96429 553-19-5 C14H12O3 = 228.24 5mg QQ客服:215959384
    黄木亭; Xanthoxyletin CFN96284 84-99-1 C15H14O4 = 258.3 5mg QQ客服:3257982914
    10-甲氧基-8,8-二甲基-2H,8H-苯并[1,2-b:5,4-b']二吡喃-2-酮; Luvangetin CFN89243 483-92-1 C15H14O4 = 258.27 5mg QQ客服:215959384
    去甲基鲁望桔内酯; Demethylluvangetin CFN89286 64652-10-4 C14H12O4 = 244.24 5mg QQ客服:2056216494
    3'-Hydroxyxanthyletin; 3'-Hydroxyxanthyletin CFN91704 165900-08-3 C14H12O4 = 244.2 5mg QQ客服:1457312923
    3',4'-二氢-3'-羟基-花椒内酯; 3',4'-dihydro-3'-hydroxy-Xanthyletin CFN92775 5993-18-0 C14H14O4 = 246.3 5mg QQ客服:3257982914
    日本前胡醇; Decursinol CFN90496 23458-02-8 C14H14O4 = 246.26 20mg QQ客服:2056216494

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