| In vitro: |
| Phytother Res. 2008 Dec;22(12):1650-4. | | Licoflavone C attenuates the genotoxicity of cancer drugs in human peripheral lymphocytes.[Pubmed: 18979523] | Flavonoids exhibit a wide spectrum of biological activities that can lead to beneficial effects for human health.
METHODS AND RESULTS:
The search for cytotoxic, genotoxic and/or antimutagenic natural compounds is therefore of great relevance, especially in cancer chemotherapy. In view of this, we screened the potential genotoxicity/antigenotoxicty of licoflavone C (LFLC) - a naturally occurring prenyl-flavone extracted from Genista ephedroides - using the micronucleus (MN) assay on stimulated and cytochalasin B-blocked human lymphocytes. LFLC did not increase the spontaneous MN level up to 600 microM final concentration where a strong toxicity was seen to occur. We therefore performed an antigenotoxicity assay against the two mutagenic anticancer drugs, mitomycin C (MMC) and daunorubicin (DAU), using two non-toxic LFLC concentrations (0.1 microM and 1.0 microM). The MN frequencies induced by 0.025 microg/ml or 0.05 microg/ml DAU were significantly lowered by 45.4% or 46.6% and 41.8% or 44.8% at LFLC 0.1 and 1.0 microM, respectively. After treatment with 0.085 microg/ml or 0.17 microg/ml MMC, we detected a reduction in genotoxicity of 35.1% or 37.0% and of 38.0% or 35.8% at LFLC 0.1 and 1.0 microM, respectively.
CONCLUSIONS:
In conclusion, LFLC was proven to be protective toward the chromosome damage induced by DAU or MMC in cultured human peripheral lymphocytes. | | Molecules. 2012 Jun 13;17(6):7284-93. | | Antibacterial, antifungal and cytotoxic activities of two flavonoids from Retama raetam flowers.[Pubmed: 22695233] | We have investigated the antibacterial, antifungal and cytotoxic activities of two flavonoids isolated from Retama raetam flowers using the disc diffusion and micro-dilution broth methods.
METHODS AND RESULTS:
The cytotoxic activity was tested against Hep-2 cells using the MTT assay. The compounds Licoflavone C (1) and derrone (2) were active against Pseudomonas aeruginosa and Escherichia coli (7.81-15.62 μg/mL) and showed important antifungal activity.
Strong antifungal activity against Candida species (7.81 μg/mL) was for example found with compound 2. The tested compounds also showed strong cytotoxicity against Hep-2 cells.
CONCLUSIONS:
These two compounds may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens. |
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