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  • 甘草查尔酮B

    Licochalcone B

    甘草查尔酮B
    产品编号 CFN99576
    CAS编号 58749-23-8
    分子式 = 分子量 C16H14O5 = 286.28
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Chalcones
    植物来源 The roots of Glycyrrhiza glabra L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    甘草查尔酮B CFN99576 58749-23-8 10mg QQ客服:2159513211
    甘草查尔酮B CFN99576 58749-23-8 20mg QQ客服:2159513211
    甘草查尔酮B CFN99576 58749-23-8 50mg QQ客服:2159513211
    甘草查尔酮B CFN99576 58749-23-8 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Universite de Lille1 (France)
  • Complutense University of Madrid (Spain)
  • Shanghai University of TCM (China)
  • University of Indonesia (Indonesia)
  • Medizinische Universit?t Wien (Austria)
  • Siksha O Anusandhan University (India)
  • Ain Shams University (Egypt)
  • Aveiro University (Portugal)
  • University of Amsterdam (Netherlands)
  • Celltrion Chemical Research Institute (Korea)
  • Universidad de Antioquia (Colombia)
  • Technical University of Denmark (Denmark)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Neurotoxicology.2022, 91:218-227.
  • Chem. of Vegetable Raw Materials2020, 97-105
  • J Appl Toxicol.2020, 40(7):965-978.
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • Free Radic Biol Med.2016, 97:307-319
  • Front Plant Sci.2022, 13:982771.
  • Toxicol In Vitro.2018, 52:94-105
  • Korean J of Medicinal Crop Science2018, 220-226
  • J Appl Microbiol.2022, 132(2):949-963.
  • Cancers (Basel).2023, 15(1):293.
  • Molecules.2019, 24(17):E3127
  • J Ginseng Res.2020, 44(4):611-618.
  • J Agric Food Chem.2019, 67(27):7748-7754
  • Phytochemistry Letters2017, 449-455
  • Inflammation.2020, 43(5):1716-1728.
  • BMC Complement Altern Med.2014, 14:352
  • Onco Targets Ther.2017, 10:3467-3474
  • Molecules.2021, 26(6):1635.
  • HortTechnology2016, 26(6):816-819
  • Front Pharmacol.2016, 7:460
  • Molecules.2019, 24(4):E709
  • J Cell Mol Med.2021, 25(5):2645-2654.
  • Int Immunopharmacol.2021, 100:108073.
  • ...
  • 生物活性
    Description: Licochalcone B has antitumor, antimetastatic, cardioprotective, antioxidant, antiapoptotic, and anti-inflammatory effects, it can significantly inhibit LPS-induced phosphorylation at serine 276 and transcriptional activation of NF-KB. Licochalcone B can protect the liver from carbon tetrachloride (CCl4)-induced injury, the protection may be due to inhibition of p38 and NFκB signaling, which subsequently reduces inflammation in the liver.
    Targets: CDK | PARP | Bcl-2/Bax | p38MAPK | Caspase | MMP(e.g.TIMP) | NF-kB | p65 | AP-1 | IkB | TNF-α | PKA | NO | ROS | IL Receptor | IKK
    In vitro:
    Food Chem Toxicol. 2014 Mar;65:242-51.
    Licochalcone B inhibits growth of bladder cancer cells by arresting cell cycle progression and inducing apoptosis.[Pubmed: 24384411]
    To examine the mechanisms by which licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (murine bladder cancer cell line) tumor model.
    METHODS AND RESULTS:
    Exposure of T24 or EJ cells to LCB significantly inhibited cell lines proliferation in a concentration-dependent and time-dependent manner, and resulted in S phase arrest in T24 or EJ cells, respectively. LCB treatment decreased the expression of cyclin A, cyclin-dependent kinase (CDK1 and CDK2) mRNA, cell division cycle 25 (Cdc25A and Cdc25B) protein. In addition, LCB treatment down-regulated Bcl-2 and survivin expression, enhanced Bax expression, activated caspase-3 and cleaved poly (ADP-ribose) polymerase (PARP) protein. Consistently, the tumorigenicity of LCB-treated MB49 cells was limited significantly by using the colony formation assay in vitro and the MB49 tumor model performed in C57BL/6 mice in vivo.
    CONCLUSIONS:
    These findings provide support for the use of LCB in chemoprevention and bladder cancer therapy.
    Int Immunopharmacol. 2009 Apr;9(4):499-507.
    Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway.[Pubmed: 19291859]
    Licorice root has been used as a traditional medicine for the treatment of gastric ulcer, bronchial asthma and inflammation. Licochalcone A is a major component of Xinjiang licorice, Glycyrrhiza inflata.
    METHODS AND RESULTS:
    Previously we showed that Licochalcone A significantly inhibited LPS-induced NF-kappaB transcriptional activation by abrogating the phosphorylation of NF-kappaB p65 at serine 276. Glycyrrhiza inflata contains not only Licochalcone A but also Licochalcone B, Licochalcone C, Licochalcone D, Echinatin and Isoliquiritigenin, harboring the common structure of chalcones. No chalcones had any effect on LPS-induced IkappaB degradation, nuclear translocation and DNA binding activity of NF-kappaB p65; however, we observed that Licochalcone B and Licochalcone D significantly inhibited LPS-induced phosphorylation at serine 276 and transcriptional activation of NF-kappaB, the same as Licochalcone A. Interestingly, we also found that Licochalcone A, Licochalcone B and Licochalcone D effectively inhibited LPS-induced activation of PKA, which is required for the phosphorylation of NF-kappaB p65 at serine 276. Consequently, Licochalcone B and Licochalcone D significantly reduced the LPS-induced production of NO, TNFalpha and MCP-1. On the other hand, Licochalcone C, Echinatin and Isoliquitigenin failed to inhibit LPS-induced NF-kappaB activation.
    CONCLUSIONS:
    These findings suggest that the anti-inflammatory effect of Glycyrrhiza inflata is ascribable to the potent inhibition of NF-kappaB by Licochalcone A, Licochalcone B and Licochalcone D.
    Nat Prod Res . 2020 Mar;34(5):736-739.
    Licochalcone B, a chalcone derivative from Glycyrrhiza inflata, as a multifunctional agent for the treatment of Alzheimer's disease[Pubmed: 30345819]
    Abstract Licochalcone B (LCB), an extract from the root of Glycyrrhiza inflate, has the same caffeic acid scaffold as curcumin (Cur), which is known as an anti-Alzheimer's disease (AD) agent. However, there is no relevant research about anti-AD activity of LCB. In this study, the anti-AD activity of LCB was investigated. LCB could inhibit amyloid beta (Aβ42) self-aggregation (IC50 = 2.16 ± 0.24 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ions. Molecular docking further revealed that LCB inhibited Aβ42 self-aggregation through forming two hydrogen bonds with Lys28 to block the salt bridge interaction at the C-terminus of Aβ42. Anti-oxidant property of LCB was also observed by DCFH-DA assay. In addition, LCB did show neuroprotective activity against H2O2-induced cell death in SH-SY5Y cells. In general, our results demonstrate that LCB, as a multifunctional agent, is likely to be promising therapeutics for AD.
    Phytomedicine . 2019 Oct;63:153014.
    Licochalcone B inhibits growth and induces apoptosis of human non-small-cell lung cancer cells by dual targeting of EGFR and MET[Pubmed: 31323446]
    Abstract Background: Epidermal growth factor receptor (EGFR) gene alterations are associated with sensitization to tyrosine kinase inhibitors such as gefitinib in lung cancer. Some patients suffering from non-small cell lung cancer (NSCLC) have difficulty in treating the cancer due to resistance acquired to gefitinib with MET amplification. Therefore EGFR and MET may be attractive targets for lung cancer therapy. Purpose: This study aimed to investigate the anti-cancer activity of Licochalcone (LC)B extracted from Glycyrrhiza inflata, in gefitinib-sensitive or gefitinib-resistant NSCLC cells, and to define its mechanisms. Study design: We investigated the mechanism of action of LCB by targeting EGFR and MET in human NSCLC cells. Methods: We used the HCC827 and HCC827GR lines as gefitinib-sensitive and -resistant cells respectively, and determined the effects of LCB on both, by performing cell proliferation assay, flow cytometry analysis and Western blotting. Targets of LCB were identified by pull-down/kinase assay and molecular docking simulation. Results: LCB inhibited both EGFR and MET kinase activity by directly binding to their ATP-binding pockets. The ability of this interaction was verified by computational docking and molecular dynamics simulations. LCB suppressed viability and colony formation of both HCC827 and HCC827GR cells while exhibiting no cytotoxicity to normal cells. The induction of G2/M cell-cycle arrest and apoptosis by LCB was confirmed by Annexin V/7-AAD double staining, ER stress and reactive oxygen species induction, mitochondrial membrane potential loss and caspase activation as well as related-proteins regulation. Inhibition of EGFR and MET by LCB decreased ERBB3 and AKT axis activation. Conclusion: We provide insights into the LCB-mediated mechanisms involved in reducing cell proliferation and inducing apoptosis in NSCLC cells. This occurs through dual inhibition of EGFR and MET in NSCLC cells regardless of their sensitivity or resistance to gefitinib. LCB may be a promising novel therapeutic medicine for gefitinib-sensitive or resistant NSCLC treatment. Keywords: Apoptosis; EGFR; Licochalcone B; MET; Non-small cell lung cancer.
    In vivo:
    Chem Biol Interact. 2014 Oct 29;224C:142-148.
    (E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one, a novel licochalcone B derivative compound, suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice.[Pubmed: 25451593]
    Activated macrophages mediate inflammation, as they release nitric oxide and pro-inflammatory cytokines in various inflammatory diseases. Suppressing macrophage activation may alleviate inflammatory processes.
    METHODS AND RESULTS:
    Here, we report that (E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one (DDP), a novel Licochalcone B derivative compound, inhibits inflammatory reactions in macrophages and protects mice from endotoxin shock. In vitro experiments showed that DDP suppressed the generation of nitric oxide and pro-inflammatory cytokines by suppressing the activation of nuclear factor-κB and activator protein-1 and simultaneously inhibited its upstream inflammatory signaling cascades in lipopolysaccharide in RAW264.7 cells. In an animal model, DDP protected BALB/c mice from lipopolysaccharide-induced endotoxin shock, possibly through inhibition of the production of inflammatory cytokines.
    CONCLUSIONS:
    DDP inhibited the production of inflammatory mediators and may be a potential target for treatment of various inflammatory diseases.
    Oxid Med Cell Longev. 2014;2014:134862.
    Cardioprotection against ischemia/reperfusion by licochalcone B in isolated rat hearts.[Pubmed: 25215172]
    The generation of reactive oxygen species (ROS) is a major cause of heart injury induced by ischemia-reperfusion. The left ventricular developed pressure (LVDP) and the maximum up/down rate of left ventricular pressure (±dp/dt(max)) were documented by a physiological recorder.
    METHODS AND RESULTS:
    Myocardial infarct size was estimated macroscopically using 2,3,5-triphenyltetrazolium chloride staining. Coronary effluent was analyzed for lactate dehydrogenase (LDH) and creatine kinase (CK) release to assess the degree of cardiac injury. The levels of C-reactive protein (CRP), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) were analyzed to determine the inflammation status of the myocardial tissue. Cardiomyocyte apoptosis analysis was performed using the In Situ Cell Death Detection Kit, POD. Accordingly, Licochalcone B pretreatment improved the heart rate (HR), increased LVDP, and decreased CK and LDH levels in coronary flow. SOD level and GSH/GSSG ratio increased, whereas the levels of MDA, TNF-α, and CRP and activities of IL-8 and IL-6 decreased in Licochalcone B-treated groups. The infarct size and cell apoptosis in hearts from Licochalcone B-treated group were lower than those in hearts from the I/R control group.
    CONCLUSIONS:
    Therefore, the cardioprotective effects of Licochalcone B may be attributed to its antioxidant, antiapoptotic, and anti-inflammatory activities.
    EMBO Rep . 2022 Feb 3;23(2):e53499.
    Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7-NLRP3 interaction[Pubmed: 34882936]
    Abstract The activation of the nucleotide oligomerization domain (NOD)-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome is related to the pathogenesis of a wide range of inflammatory diseases, but drugs targeting the NLRP3 inflammasome are still scarce. In the present study, we demonstrated that Licochalcone B (LicoB), a main component of the traditional medicinal herb licorice, is a specific inhibitor of the NLRP3 inflammasome. LicoB inhibits the activation of the NLRP3 inflammasome in macrophages but has no effect on the activation of AIM2 or NLRC4 inflammasome. Mechanistically, LicoB directly binds to NEK7 and inhibits the interaction between NLRP3 and NEK7, thus suppressing NLRP3 inflammasome activation. Furthermore, LicoB exhibits protective effects in mouse models of NLRP3 inflammasome-mediated diseases, including lipopolysaccharide (LPS)-induced septic shock, MSU-induced peritonitis and non-alcoholic steatohepatitis (NASH). Our findings indicate that LicoB is a specific NLRP3 inhibitor and a promising candidate for treating NLRP3 inflammasome-related diseases. Keywords: LPS-induced septic shock; Licochalcone B; MSU-induced peritonitis; NASH; NEK7; NLRP3 inflammasome.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4931 mL 17.4654 mL 34.9308 mL 69.8617 mL 87.3271 mL
    5 mM 0.6986 mL 3.4931 mL 6.9862 mL 13.9723 mL 17.4654 mL
    10 mM 0.3493 mL 1.7465 mL 3.4931 mL 6.9862 mL 8.7327 mL
    50 mM 0.0699 mL 0.3493 mL 0.6986 mL 1.3972 mL 1.7465 mL
    100 mM 0.0349 mL 0.1747 mL 0.3493 mL 0.6986 mL 0.8733 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    龙血素C; Loureirin C CFN92858 116384-24-8 C16H16O4 = 272.3 10mg QQ客服:215959384
    4-O-甲基刺甘草查尔酮; 4'-Hydroxy-2,4-dimethoxychalcone CFN91163 151135-64-7 C17H16O4 = 284.3 10mg QQ客服:1457312923
    龙血素A; Loureirin A CFN92766 119425-89-7 C17H18O4 = 286.3 20mg QQ客服:1413575084
    甘草查尔酮B; Licochalcone B CFN99576 58749-23-8 C16H14O5 = 286.28 20mg QQ客服:3257982914
    3,3',4,4'-四羟基-2-甲氧基查尔酮; Tetrahydroxymethoxychalcone CFN91674 197227-39-7 C16H14O6 = 302.28 5mg QQ客服:3257982914
    龙血素D; Loureirin D CFN92676 119425-91-1 C16H16O5 = 288.3 10mg QQ客服:1413575084
    4,4'-二羟基-2,6-二甲氧基二氢查耳酮; 4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone CFN91700 151752-08-8 C17H18O5 = 302.3 5mg QQ客服:2056216494
    龙血素B; Loureirin B CFN98173 119425-90-0 C18H20O5 = 316.35 20mg QQ客服:1457312923
    2',4'-二氢查耳酮; 2',4'-Dihydroxydihydrochalcone CFN70401 53596-71-7 C15H14O3 = 242.3 20mg QQ客服:1457312923
    4'-羟基查耳酮; 2-Benzal-4-hydroxyacetophenone CFN70089 2657-25-2 C15H12O2 = 224.2 20mg QQ客服:2056216494

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