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  • (-)-利卡灵B

    (-)-Licarin B

    (-)-利卡灵B
    产品编号 CFN99751
    CAS编号 51020-87-2
    分子式 = 分子量 C20H20O4 = 324.37
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Lignans
    植物来源 The seeds of Myristica fragrans Houtt.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    (-)-利卡灵B CFN99751 51020-87-2 3mg QQ客服:3257982914
    (-)-利卡灵B CFN99751 51020-87-2 6mg QQ客服:3257982914
    (-)-利卡灵B CFN99751 51020-87-2 9mg QQ客服:3257982914
    (-)-利卡灵B CFN99751 51020-87-2 12mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Istanbul University (Turkey)
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  • Griffith University (Australia)
  • Deutsches Krebsforschungszentrum (Germany)
  • Semmelweis Unicersity (Hungary)
  • Indian Institute of Science (India)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Ecol Evol.2022, 12(11):e9459.
  • Front Pharmacol.2023, 14:1095083.
  • Kor. J. Pharmacogn.2016, 47(1):62-72
  • Environ Toxicol.2020, doi: 10.1002
  • Institute of Food Science & Technology2021, 45(9).
  • Plant Physiol Biochem.2019, 144:355-364
  • Exp Biol Med (Maywood).2019, 244(16):1463-1474
  • J. of Med. Plant Research.2013, 90-151
  • J Nat Prod.2023, 86(2):264-275.
  • Food Addit Contam Part A.2021, 38(12):1985-1994.
  • Appl. Sci.2020, 10(5),1713.
  • Arch Biochem Biophys.2020, 687:108384.
  • Oncol Lett.2020, 20(4):122.
  • Molecules.2021, 26(16):4722.
  • LWT2021, 138:110630.
  • Phytomedicine.2018, 40:37-47
  • J.Food Processing & Preservation2022, jfpp.16666
  • Chemistr of plant2016, 2016021195
  • Biomolecules.2023, 13(2):227.
  • Foods.2022, 11(12):1773.
  • LWT2021, 138:110397.
  • Molecules.2020, 25(11):2599.
  • J Ethnopharmacol.2020, 269:113752.
  • ...
  • 生物活性
    Description: Licarin B can improve insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway in 3T3-L1 adipocytes, it as a promising bioactive for insulin resistance and associated complications through its partial PPARγ activity.
    Targets: PPAR | GLUT | PI3K | Akt | IRS-1
    In vitro:
    Rsc Adv., 2016, 6(83):79859-70.
    Licarin B from Myristica fragrans improves insulin sensitivity via PPARγ and activation of GLUT4 in IRS-1/PI3K/AKT pathway in 3T3- L1 adipocytes[Reference: WebLink]
    Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors regulating lipid and glucose metabolism.
    METHODS AND RESULTS:
    The objective of the present study is to characterize the cellular effect of Licarin B (LB), a neolignan isolated from Myristica fragrans on the PPARγ and insulin signaling pathways in 3T3-L1 preadipocytes. The molecular mechanism of action of LB on PPARγ and insulin signaling pathways were studied using in vitro and in silico methods. Functional activation of PPARγ in vitro was confirmed by 3T3-L1 preadipocyte differentiation, regulation of target genes and protein expression. LB caused triglyceride accumulation during adipogenesis but significantly less compared to rosiglitazone (RG), a PPARγ full agonist. In in vitro time-resolved fluorescence resonance energy transfer-based competitive binding assay, LB showed an IC50 value of 2.4 μM whereas for RG and GW9662 it was 57.96 nM and 18.68 nM respectively. Virtual screening of LB with PPARγ showed hydrophobic interactions with a binding energy of -9.36 kcal mol⁻1. Interestingly enough LB improved insulin sensitivity by up regulating the GLUT4 expression and translocation via IRS-1/PI3K/AKT pathway, enhanced adiponectin secretion and modulated mRNA expression profile of PPARγ target genes C/EBPα, IRS-2, and LPL significantly compared to RG.
    CONCLUSIONS:
    This scientifically validate LB as a promising bioactive for insulin resistance and associated complications through its partial PPARγ activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0829 mL 15.4145 mL 30.829 mL 61.658 mL 77.0725 mL
    5 mM 0.6166 mL 3.0829 mL 6.1658 mL 12.3316 mL 15.4145 mL
    10 mM 0.3083 mL 1.5414 mL 3.0829 mL 6.1658 mL 7.7072 mL
    50 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.2332 mL 1.5414 mL
    100 mM 0.0308 mL 0.1541 mL 0.3083 mL 0.6166 mL 0.7707 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (-)-白玉兰亭B; 玉兰脂B; Denudatin B CFN97599 87402-88-8 C21H24O5 = 356.42 5mg QQ客服:1457312923
    Conocarpan; Conocarpan CFN98208 221666-27-9 C18H18O2 = 266.3 5mg QQ客服:2159513211
    Conocarpan acetate; Conocarpan acetate CFN89302 56319-04-1 C20H20O3 = 308.37 5mg QQ客服:2159513211
    利卡灵A; Licarin A CFN98244 23518-30-1 C20H22O4 = 326.4 5mg QQ客服:1457312923
    去氢二异丁香酚; Dehydrodiisoeugenol CFN99750 2680-81-1 C20H22O4 = 326.39 20mg QQ客服:1413575084
    (-)-利卡灵B; (-)-Licarin B CFN99751 51020-87-2 C20H20O4 = 324.37 3mg QQ客服:215959384
    Odoratisol A; Odoratisol A CFN90908 891182-93-7 C21H24O5 = 356.41 5mg QQ客服:1457312923
    粗毛淫羊藿苷; Acuminatin CFN98656 41744-39-2 C21H24O4 = 340.4 5mg QQ客服:2056216494
    淫羊藿次甙E5; Icariside E5 CFN99373 126176-79-2 C26H34O11 = 522.6 5mg QQ客服:1413575084
    Ailanthoidol; Ailanthoidol CFN89428 156398-61-7 C19H18O5 = 326.34 5mg QQ客服:1457312923

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