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  • 欧当归内酯A

    Levistilide A

    欧当归内酯A
    产品编号 CFN99707
    CAS编号 88182-33-6
    分子式 = 分子量 C24H28O4 = 380.48
    产品纯度 >=98%
    物理属性 Solid
    化合物类型 Miscellaneous
    植物来源 The roots of Angelica sinensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    欧当归内酯A CFN99707 88182-33-6 10mg QQ客服:1457312923
    欧当归内酯A CFN99707 88182-33-6 20mg QQ客服:1457312923
    欧当归内酯A CFN99707 88182-33-6 50mg QQ客服:1457312923
    欧当归内酯A CFN99707 88182-33-6 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • S.N.D.T. Women's University (India)
  • Universidad de Buenos Aires (Argentina)
  • Korea Food Research Institute(KFRI) (Korea)
  • Charles University in Prague (Czech Republic)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Technical University of Denmark (Denmark)
  • Kyushu University (Japan)
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  • Universidade da Beira Interior (Germany)
  • Shanghai University of TCM (China)
  • University of Illinois at Chicago (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2021, 22(2):770.
  • JEJU National University2022, 24032.
  • Molecules.2017, 22(3)
  • Research Square2023, 2883170.
  • Journal of Applied Pharmaceutical Science2022, 0(00), pp:001-007
  • Free Radic Biol Med.2016, 97:307-319
  • Phytomedicine.2022, 100:154058.
  • Korean Journal of Pharmacognosy.2015, 46(4):352-364
  • Metabolites.2020, 10(12):497.
  • Kasetsart University2022, ethesis.1144.
  • J Neuroinflammation.2020, 17(1):75.
  • Biochem Pharmacol. 2020, 177:114014.
  • Int J Biol Macromol.2019, 126:653-661
  • Med Sci Monit.2019, 25:9499-9508
  • Foods.2022, 11(12):1708.
  • Int. J. Mol. Sci. 2022, 23(3),1696.
  • Evid Based Complement Alternat Med.2021, 8855980.
  • J Nat Sc Biol Med2019, 10(2):149-156
  • Biomed Pharmacother.2022, 145:112410.
  • Journal of Third Military Medical University2019, 41(2):110-115
  • Theranostics.2023, 13(9):3103-3116.
  • Sci Rep.2019, 9:12132
  • Pharmacol Rep.2020, 72(2):472-480.
  • ...
  • 生物活性
    Description: Traditional formula compatibility of Danggui-Shaoyao-San could significantly enhance levistilide A bioavailability compared with levistilide A alone and Rhizoma Chuanxiong.
    In vitro:
    Cell Physiol Biochem . 2017;42(3):929-938.
    Levistolide A Induces Apoptosis via ROS-Mediated ER Stress Pathway in Colon Cancer Cells[Pubmed: 28662507]
    Abstract Background/aims: Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Levistolide A (LA), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is used for treating cancer. In this study, we investigated the anticancer effect of LA in HCT116 and its isogenic p53-/- colon cancer cells, as well as the underlying mechanisms. Methods: MTT assay was used to evaluate the effect of LA on the viability of cancer cells. Apoptosis and reactive oxygen species (ROS) production by the cells were determined by flow cytometry. Protein expression was detected by western blotting. Results: The results showed that LA inhibited viability and caused apoptosis of both wild-type and p53-/- HCT116 cells. LA was able to trigger production of ROS and endoplasmic reticulum (ER) stress. Inhibition of ROS using N-acetylcysteine abrogated LA-induced ER stress and apoptosis, as well as the reduction in cancer cell viability. Conclusion: Our results indicate that LA causes apoptosis of colon cancer cells via ROS-mediated ER stress pathway. It will be interesting to develop the natural compound for chemotherapy of cancers such as CRC. Keywords: Apoptosis; ER stress; Levistolide A; ROS.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6283 mL 13.1413 mL 26.2826 mL 52.5652 mL 65.7065 mL
    5 mM 0.5257 mL 2.6283 mL 5.2565 mL 10.513 mL 13.1413 mL
    10 mM 0.2628 mL 1.3141 mL 2.6283 mL 5.2565 mL 6.5706 mL
    50 mM 0.0526 mL 0.2628 mL 0.5257 mL 1.0513 mL 1.3141 mL
    100 mM 0.0263 mL 0.1314 mL 0.2628 mL 0.5257 mL 0.6571 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    洋川芎内酯N; Senkyunolide N CFN95449 140694-58-2 C12H18O4 = 226.3 10mg QQ客服:1413575084
    洋川芎内酯H; Senkyunolide H CFN99595 94596-27-7 C12H16O4 = 224.3 20mg QQ客服:215959384
    洋川芎内酯I; Senkyunolide I CFN99596 94596-28-8 C12H16O4 = 224.3 20mg QQ客服:2159513211
    6-Hydroxy-7-methoxydihydroligustilide; 6-Hydroxy-7-methoxydihydroligustilide CFN95289 210036-09-2 C13H18O4 = 238.3 5mg QQ客服:1457312923
    Riligustilide; Riligustilide CFN95457 89354-45-0 C24H28O4 = 380.5 5mg QQ客服:1413575084
    Angelicolide; Angelicolide CFN93014 90826-58-7 C24H28O4 = 380.48 5mg QQ客服:1413575084
    欧当归内酯A; Levistilide A CFN99707 88182-33-6 C24H28O4 = 380.48 20mg QQ客服:3257982914
    Tokinolide B; Tokinolide B CFN90612 112966-16-2 C24H28O4 = 380.48 10mg QQ客服:1457312923
    (Z)-毛叶醇内酯; (Z)-Lachnophyllum lactone CFN97868 81122-95-4 C10H10O2 = 162.2 5mg QQ客服:1457312923
    5-(2-己炔-1-基)二氢-2(3H)-呋喃酮; Tetrahydrolachnophyllum lactone CFN97885 56407-87-5 C10H14O2 = 166.2 5mg QQ客服:215959384

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