Leucodin

	产品编号	CFN96803
	CAS编号	17946-87-1
	分子式 = 分子量	C₁₅H₁₈O₃ = 246.30
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Sesquiterpenoids
	植物来源	The roots of Scorzonera latifolia (Fisch. and Mey.) DC.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Leucodin	CFN96803	17946-87-1	1mg	QQ客服：3257982914
Leucodin	CFN96803	17946-87-1	5mg	QQ客服：3257982914
Leucodin	CFN96803	17946-87-1	10mg	QQ客服：3257982914
Leucodin	CFN96803	17946-87-1	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

National Cancer Institute (USA)

The University of Newcastle (Australia)

Aveiro University (Portugal)

University of Melbourne (Australia)

Universit?t Basel (Switzerland)

Regional Crop Research Institute (Korea)

Universidad Veracuzana (Mexico)

Institute of Chinese Materia Medica (China)

Universitas Airlangga (Indonesia)

Chinese University of Hong Kong (China)

Seoul National University (Korea)

Northeast Normal University Changchun (China)

Griffith University (Australia)

National Hellenic Research Foundation (Greece)

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Description:

Leucodin shows high anti-hypercholesterolemic potential. Leucodin may have anti-allergic activity, it shows a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner with IC50 of 80 microM.

Targets:

TNF-α | MMP(e.g.TIMP)

In vitro:

Molecules. 2016 Mar 25;21(4):404.

The Chemical Composition of Achillea wilhelmsii C. Koch and Its Desirable Effects on Hyperglycemia, Inflammatory Mediators and Hypercholesterolemia as Risk Factors for Cardiometabolic Disease.[Pubmed: 27023504 ]

METHODS AND RESULTS:
The chloroform fraction (CF) and ethyl acetate fraction (EAF) both showed a significant ability to reduce the secretion of tumor necrosis factor alpha (TNF-α). The EAF, however, also attenuated the levels of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). The CF showed the most significant 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibition activity. The five main compounds in the CF were isolated and identified.
CONCLUSIONS:
Out of the five compounds in the CF, 1β,10β-epoxydesacetoxymatricarin (CP1) and Leucodin (CP2) showed the highest anti-hypercholesterolemic potential. A molecular docking study provided corresponding results.

Planta Med. 1998 Aug;64(6):577-8.

Desacetylmatricarin, an anti-allergic component from Taraxacum platycarpum.[Pubmed: 9741305]

METHODS AND RESULTS:
The bioassay-guided fractionation of Taraxacum platycarpum (Compositae) extract led to the isolation of a desacetylmatricarin (1) as an active principle responsible for the anti-allergic property.
CONCLUSIONS:
It showed a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner and the IC50 was 7.5 microM. Two structurally related guaianolide sesquiterpenes, achillin and Leucodin, were also examined and their IC50 values were determined as 100 microM and 80 microM, respectively.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
磺酸基木香烯内酯B; Sulfocostunolide B	CFN99075	1059671-65-6	C₁₅H₂₀O₅S = 312.4	5mg	QQ客服：2056216494
1alpha,4beta,10beta-Trihydroxyguaia-2,11(13)-dien-12,6alpha-olide; 1alpha,4beta,10beta-Trihydroxyguaia-2,11(13)-dien-12,6alpha-olide	CFN89195	221148-94-3	C₁₅H₂₀O₅ = 280.32	5mg	QQ客服：1457312923
林泽兰内酯B; Eupalinilide B	CFN90378	757202-08-7	C₂₀H₂₄O₆ = 360.41	10mg	QQ客服：1413575084
林泽兰内酯C; Eupalinilide C	CFN90379	757202-11-2	C₂₀H₂₄O₇ = 376.4	5mg	QQ客服：1413575084
林泽兰内酯D; Eupalinilide D	CFN90380	757202-14-5	C₁₅H₁₉ClO₅ = 314.76	10mg	QQ客服：1413575084
8-Epicrepiside E; 8-Epicrepiside E	CFN96796	93395-30-3	C₂₁H₂₈O₉ = 424.44	5mg	QQ客服：2056216494
菜蓟苦素; Cynaropicrin	CFN93077	35730-78-0	C₁₉H₂₂O₆ = 346.37	5mg	QQ客服：215959384
(2R)-2-羟基-2-甲基-3-氧代丁酸(3aR,4R,6aR,8S,9aR,9bR)-8-(beta-D-吡喃葡萄糖基氧基)十二氢-3,6,9-三(亚甲基)-2-氧代薁并[4,5-b]呋喃-4-基酯; 8beta-(2-Hydroxy-2-methyl-3-oxobutyryloxy)glucozaluzanin C	CFN96392	93395-31-4	C₂₆H₃₄O₁₂ = 538.6	5mg	QQ客服：215959384
Tectoroside; Tectoroside	CFN96382	124960-89-0	C₃₀H₃₆O₁₂ = 588.6	5mg	QQ客服：1413575084
Arglabin; Arglabin	CFN89201	84692-91-1	C₁₅H₁₈O₃ = 246.30	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.0601 mL	20.3004 mL	40.6009 mL	81.2018 mL	101.5022 mL
5 mM	0.812 mL	4.0601 mL	8.1202 mL	16.2404 mL	20.3004 mL
10 mM	0.406 mL	2.03 mL	4.0601 mL	8.1202 mL	10.1502 mL
50 mM	0.0812 mL	0.406 mL	0.812 mL	1.624 mL	2.03 mL
100 mM	0.0406 mL	0.203 mL	0.406 mL	0.812 mL	1.015 mL