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  • 阔叶碱

    Latifoline

    阔叶碱
    产品编号 CFN00266
    CAS编号 6029-86-3
    分子式 = 分子量 C20H27NO7 = 393.44
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Hackelia floribunda
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    阔叶碱 CFN00266 6029-86-3 1mg QQ客服:1413575084
    阔叶碱 CFN00266 6029-86-3 5mg QQ客服:1413575084
    阔叶碱 CFN00266 6029-86-3 10mg QQ客服:1413575084
    阔叶碱 CFN00266 6029-86-3 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • University of Malaya (Malaysia)
  • Sapienza University of Rome (Italy)
  • University of Canterbury (New Zealand)
  • Monash University Sunway Campus (Malaysia)
  • Biotech R&D Institute (USA)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Utah State University (USA)
  • Medical University of South Carolina (USA)
  • Sri Ramachandra University (India)
  • Anna University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Br J Pharmacol.2018, 175(6):902-923
  • Applied Biological Chemistry2022, 71:s13765-022-00743-5.
  • Phytomedicine2022, 104:154318
  • Academic J of Second Military Medical University2018, 39(11)
  • American Association for Anatomy2020, doi: 10.1002.
  • Nutrients2020, 12(3):811.
  • In Vitro Cellular & Developmental Biology - Plant2022, 58:972-988.
  • Front Microbiol.2022, 12:833233.
  • Int J Mol Sci.2020, 21(19):7209.
  • Hindawi J of Food Biochemistry2023, P17:8883860
  • Natural Product Communications2020, doi: 10.1177.
  • Food Addit Contam Part A.2021, 38(12):1985-1994.
  • Int J Mol Sci.2022, 23(5):2796.
  • Exp Neurobiol.2018, 27(3):200-209
  • Oxid Med Cell Longev.2021, 2021:6647107.
  • Front Immunol.2017, 8:1542
  • J Chromatogr A.2017, 1518:46-58
  • Nutrients.2020, 12(11):3448.
  • Molecules.2019, 24(20):3755
  • Natural Product Communications2020, doi: 10.1177.
  • Foods.2022, 11(6):882.
  • Hum Exp Toxicol.2022, 41:9603271221143713.
  • Biochem Biophys Res Commun.2020, 527(4):889-895.
  • ...
  • 生物活性
    Description: Reference standards.
    In vitro:
    Toxicol Appl Pharmacol. 1993 Sep;122(1):61-9.
    Structural influences on pyrrolizidine alkaloid-induced cytopathology.[Pubmed: 8378933]
    Pyrrolizidine alkaloids (PAs), which are common constituents of hundreds of plant species around the world, have been reported to have cytotoxic, carcinogenic, antineoplastic, and genotoxic activity in vivo and in vitro. The exact mechanism of these biological toxicities is not yet clear.
    METHODS AND RESULTS:
    The ability of eight PA congeners to inhibit mitosis and induce megalocyte formation in cultured bovine kidney epithelial cells was studied to examine possible structural influences on these endpoints. Representatives of the three PA structural groups, the macrocycles (seneciphylline, senecionine, riddelliine, retrorsine, monocrotaline), open diesters (heliosupine, latifoline), and a necine base (retronecine), were cocultured for 2 hr with a NADPH-generating system and rat liver S9. Macrocyclic PAs with alpha,beta-unsaturation (seneciphylline, senecionine, riddelliine, retrorsine) showed a dose-dependent inhibition of colony formation at 50, 100, and 300 microM and induction of megalocytosis at 500 microM. Colony growth resumed 3 weeks after removal of PAs at 50 and 100 microM, and normal cellular morphology returned 5 or 6 weeks after removal of PAs at 500 microM. The saturated macrocyclic (monocrotaline) and open diesters (heliosupine, latifoline), elicited only a slight inhibition of colony formation and had no effect on cellular morphology at 500 microM. The necine base (retronecine) had no effect on either colony formation or cell morphology. Pyrrolic PAs (dehydrosenecionine, dehydromonocrotaline, dehydroretronecine) were more active in inhibition of colony formation than their parent compounds and were potent inducers of abnormal cellular morphology at 500 microM. An N-oxide metabolite, indicine N-oxide, was completely inactive.
    CONCLUSIONS:
    The results support previous studies showing that there are structural influences on PA-induced cytopathological effects.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5417 mL 12.7084 mL 25.4168 mL 50.8337 mL 63.5421 mL
    5 mM 0.5083 mL 2.5417 mL 5.0834 mL 10.1667 mL 12.7084 mL
    10 mM 0.2542 mL 1.2708 mL 2.5417 mL 5.0834 mL 6.3542 mL
    50 mM 0.0508 mL 0.2542 mL 0.5083 mL 1.0167 mL 1.2708 mL
    100 mM 0.0254 mL 0.1271 mL 0.2542 mL 0.5083 mL 0.6354 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    乙酰天芥菜品碱; Acetylheliosupine CFN00269 31514-30-4 C22H33NO8 = 439.50 5mg QQ客服:3257982914
    天芥菜碱; Heliotrine CFN00270 303-33-3 C16H27NO5 = 313.39 5mg QQ客服:215959384
    天芥菜碱 N-氧化物; Heliotrine N-oxide CFN00271 6209-65-0 C16H27NO6 = 329.39 5mg QQ客服:1413575084
    大叶千里光碱; Macrophylline CFN00275 27841-97-0 C13H21NO3 = 239.31 5mg QQ客服:215959384
    欧天芥菜碱; Europine CFN00264 570-19-4 C16H27NO6 = 329.39 5mg QQ客服:215959384
    欧天芥菜碱氮氧化物; Europine N-oxide CFN00265 65582-53-8 C16H27NO7 = 345.39 5mg QQ客服:215959384
    阔叶碱; Latifoline CFN00266 6029-86-3 C20H27NO7 = 393.44 5mg QQ客服:2159513211
    阔叶碱N-氧化物; Latifoline N-oxide CFN00267 98752-06-8 C20H27NO8 = 409.43 5mg QQ客服:215959384
    天芥菜品碱; Heliosupine CFN00268 32728-78-2 C20H31NO7 = 397.47 5mg QQ客服:1457312923
    天芥菜品碱N-氧化物; Heliosupine N-oxide CFN00454 31701-88-9 C20H31NO8 = 413.5 5mg QQ客服:3257982914

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