Info: Read More
  • 中药标准品生产商,产品定制服务
  • Science | Nature | Cell | View More

    牛蒡酚C

    Lappaol C

    牛蒡酚C
    产品编号 CFN95068
    CAS编号 64855-00-1
    分子式 = 分子量 C30H34O10 = 554.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The roots of Gymnadenia conopsea
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    牛蒡酚C CFN95068 64855-00-1 1mg QQ客服:1457312923
    牛蒡酚C CFN95068 64855-00-1 5mg QQ客服:1457312923
    牛蒡酚C CFN95068 64855-00-1 10mg QQ客服:1457312923
    牛蒡酚C CFN95068 64855-00-1 20mg QQ客服:1457312923
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Bordeaux (France)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Griffith University (Australia)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Florida A&M University (USA)
  • Mahatma Gandhi University (India)
  • University of Hawaii Cancer Center (USA)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Mendel University in Brno (Czech Republic)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • University of Pretoria (South Africa)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • University of Toulouse (France)
  • Center for protein Engineering (CIP) (Belgium)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules. 2013, 18(11):14105-21
  • ARPN Journal of Eng.& Applied Sci.2016, 2199-2204
  • Biomed Chromatogr.2016, 30(10):1573-81
  • Org Biomol Chem.2017, 15(31):6483-6492
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Journal of Analytical Chemistry2017, 854-861
  • Curr Eye Res.2018, 43(1):27-34
  • Chemistry of Natural Compounds2018, 54(3):572–576
  • J Mol Med (Berl).2018, 96(7):661-672
  • Exp Ther Med.2019, 18(6):4388-4396
  • J Ethnopharmacol.2019, 228:132-141
  • Molecules.2019, 24(11):E2102
  • Molecules.2019, 24(19):E3417
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • Pest Manag Sci.2019, 75(9):2530-2541
  • TCI CO.2019, US20190151281A1
  • Plos One.2020, 10.1371
  • Antioxidants (Basel).2020, 9(2):E99
  • Biochem Pharmacol.2020, 178:114083
  • UDC.2020, 19(4).
  • Int J Mol Sci.2020, 21(24):9369.
  • J Biosci.2020, 45:46.
  • ...
  • 生物活性
    Description: Lappaol C has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol C also has potential chemosensitizing activity, it may be candidates for developing novel adjuvant anticancer agents.
    Targets: JNK | P-gp
    In vivo:
    Phytochemistry. 2015 Sep;117:340-50.
    Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans.[Pubmed: 26141518]
    Arctium lappa is a well-known traditional medicinal plant in China (TCM) and Europe that has been used for thousands of years to treat arthritis, baldness or cancer. The plant produces lignans as secondary metabolites, which have a wide range of bioactivities. Yet, their antiaging potential has not been explored.
    METHODS AND RESULTS:
    In this study, we isolated six lignans from A. lappa seeds, namely arctigenin, matairesinol, arctiin, (iso)lappaol A, lappaol C, and lappaol F. The antioxidant and antiaging properties of the isolated lignans were studied using Caenorhabditis elegans as a relevant animal model. All lignans at concentrations of 10 and 100 μM significantly extended the mean life span of C. elegans. The strongest effect was observed with matairesinol, which at a concentration of 100 μM extended the life span of worms by 25%. Additionally, we observed that five lignans are strong free radical-scavengers in vitro and in vivo and all lignans can improve survival of C. elegans under oxidative stress. Furthermore, the lignans can induce the nuclear translocation of the transcription factor DAF-16 and up-regulate its expression, suggesting that a possible underlying mechanism of the observed longevity-promoting activity of lignans depends on DAF-16 mediated signaling pathway.
    CONCLUSIONS:
    All lignans up-regulated the expression of jnk-1, indicating that lignans may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Our study reports new antiaging activities of lignans, which might be candidates for developing antiaging agents.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8031 mL 9.0155 mL 18.031 mL 36.062 mL 45.0775 mL
    5 mM 0.3606 mL 1.8031 mL 3.6062 mL 7.2124 mL 9.0155 mL
    10 mM 0.1803 mL 0.9016 mL 1.8031 mL 3.6062 mL 4.5078 mL
    50 mM 0.0361 mL 0.1803 mL 0.3606 mL 0.7212 mL 0.9016 mL
    100 mM 0.018 mL 0.0902 mL 0.1803 mL 0.3606 mL 0.4508 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2,3-双(3,4-亚甲基二氧基苄基)丁-2-烯-4-内酯; 2,3-Di(3',4'-methylenedioxybenzyl)-2-buten-4-olide CFN97895 137809-97-3 C20H16O6 = 352.3 5mg QQ客服:2932563308
    7-氧代扁柏脂素; 7-Oxohinokinin CFN99396 130837-92-2 C20H16O7 = 368.3 5mg QQ客服:1457312923
    Bis-5,5-nortrachelogenin; Bis-5,5-nortrachelogenin CFN96251 870480-56-1 C40H42O14 = 746.8 5mg QQ客服:1413575084
    牛蒡酚A; Lappaol A CFN95067 62333-08-8 C30H32O9 = 536.6 10mg QQ客服:2932563308
    异牛蒡酚A; Isolappaol A CFN95224 131400-96-9 C30H32O9 = 536.6 10mg QQ客服:2932563308
    牛蒡酚C; Lappaol C CFN95068 64855-00-1 C30H34O10 = 554.6 10mg QQ客服:2159513211
    异牛蒡酚C; Isolappaol C CFN95225 929905-15-7 C30H34O10 = 554.6 10mg QQ客服:2056216494
    牛蒡酚F; Lappaol F CFN95069 69394-17-8 C40H42O12 = 714.8 10mg QQ客服:3257982914
    (+)-罗汉松树脂酚 ; (+)-Matairesinol CFN96715 148409-36-3 C20H22O6 = 358.39 5mg QQ客服:2159513211
    Isosalicifolin; Isosalicifolin CFN96234 156974-99-1 C20H20O6 = 356.4 5mg QQ客服:2932563308

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ1: 2056216494 ; QQ2: 3257982914
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产