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  • 鼠李糖

    L-Rhamnose

    鼠李糖
    产品编号 CFN99545
    CAS编号 6155-35-7
    分子式 = 分子量 C6H14O6 = 182.17
    产品纯度 >=98%
    物理属性 White cryst.
    化合物类型 Miscellaneous
    植物来源 The flowers of Scphora japonica L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    鼠李糖 CFN99545 6155-35-7 10mg QQ客服:3257982914
    鼠李糖 CFN99545 6155-35-7 20mg QQ客服:3257982914
    鼠李糖 CFN99545 6155-35-7 50mg QQ客服:3257982914
    鼠李糖 CFN99545 6155-35-7 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J of Engineering Science&Technology2018, 13(9):2820-2828
  • Front Pharmacol.2016, 7:460
  • Heliyon.2023, e12684.
  • Biol Pharm Bull.2018, 41(11):1685-1693
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  • J Ethnopharmacol.2020, 269:113752.
  • Virus Res.2023, 335:199199.
  • BMC Complement Altern Med.2014, 14:352
  • J Ethnopharmacol.2019, 228:132-141
  • Natural Product Communications2020, doi: 10.1177.
  • Nutrients.2023, 15(6):1335.
  • South African Journal of Botany2021, 142:114-123.
  • Food Chem.2020, 332:127412
  • Molecules.2021, 26(4):1084.
  • Mol Pharmacol.2021, 99(2):163-174.
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1126-1127:121743
  • Molecules.2022, 27(21):7643.
  • ...
  • 生物活性
    Description: L-Rhamnose may exhibit excellent sodium-glucose transporter (SGLT1 and SGLT2) inhibition activity. L-fucose and especially L-rhamnose have anticancer potential, they exert a significant suppressive effect on tumour growth.
    Targets: SGLT
    In vivo:
    Am J Clin Nutr. 2004 Nov;80(5):1254-61.
    L-Rhamnose increases serum propionate after long-term supplementation, but lactulose does not raise serum acetate.[Pubmed: 15531673]
    Acute ingestion of the unabsorbed sugar l-rhamnose in humans raises serum propionate, whereas acute ingestion of lactulose raises serum acetate. It is not known whether short-chain fatty acid concentrations in urine and feces reflect those in blood. The objective was to test the effects of oral l-rhamnose and lactulose for 28 d on acetate and propionate concentrations in serum, urine, and feces.
    METHODS AND RESULTS:
    Eleven subjects ingested 25 g l-rhamnose, lactulose, or d-glucose (control) for 28 d in a partially randomized crossover design. One fecal sample, hourly blood samples, and all urine samples were collected over 12 h on the last day of each phase. The increase in serum propionate was greater after l-rhamnose than after lactulose (P < 0.05). The effect of lactulose on serum acetate was not significant, but lactulose raised the acetate:propionate ratio compared with d-glucose or l-rhamnose in serum (P < 0.005) and urine (P < 0.02). Flatulence was significantly greater after lactulose and l-rhamnose than after d-glucose (P < 0.0001), an effect that lasted 4 wk with lactulose but only 1 wk with l-rhamnose.
    CONCLUSIONS:
    This study confirmed that l-rhamnose ingestion over 28 d continues to selectively raise serum propionate in humans. Although serum acetate did not increase significantly after lactulose, the serum acetate:propionate ratio was significantly different after l-rhamnose and lactulose, which suggests that these substrates could be used to examine the role of colonic acetate and propionate production in the effect of dietary fiber on lipid metabolism. Changes in the ratio of urinary acetate to propionate reflected those in serum.
    Cent. Eur. J. Biol., 2011, 6(1):1-9.
    L-rhamnose and L-fucose suppress cancer growth in mice.[Reference: WebLink]
    It is documented that deficient fucosylation may play an important role in the pathogenesis of cancer. Since the supplementation of L-fucose could restore fucosylation in both in vitro and in vivo conditions, our intent was to examine the effect of intraperitoneal administration of L-fucose and L-Rhamnose (a similar deoxysaccharide) on tumour growth, mitotic activity and metastatic setting of a solid form of Ehrlich carcinoma as well as on the survival rate of tumour bearing mice.
    METHODS AND RESULTS:
    Both L-fucose and L-Rhamnose exerted a significant suppressive effect on tumour growth (P<0.05). After 10 days of therapy, the greatest inhibition of tumour growth expressed as a percentage of controls was observed in L-Rhamnose at a dose of 3 g/kg/day (by 62%) and L-fucose at a dose of 5 g/kg/day (by 47%). Moreover, the mitotic index decreased with increasing doses of L-fucose and L-Rhamnose. Prolonged survival of tumour bearing mice was observed after 14 consecutive days of daily administering L-Rhamnose. Its optimal dose was estimated to be 3.64 g/kg/day. L-Fucose, however, displayed only a slight effect on the survival of the mice.
    CONCLUSIONS:
    Our results suggest that L-fucose and especially L-Rhamnose have anticancer potential. This study is the first to demonstrate the tumour-inhibitory effect of L-Rhamnose.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.4894 mL 27.4469 mL 54.8938 mL 109.7876 mL 137.2345 mL
    5 mM 1.0979 mL 5.4894 mL 10.9788 mL 21.9575 mL 27.4469 mL
    10 mM 0.5489 mL 2.7447 mL 5.4894 mL 10.9788 mL 13.7234 mL
    50 mM 0.1098 mL 0.5489 mL 1.0979 mL 2.1958 mL 2.7447 mL
    100 mM 0.0549 mL 0.2745 mL 0.5489 mL 1.0979 mL 1.3723 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    D-(+)-木糖; D-(+)-Xylose CFN99911 58-86-6 C5H10O5 = 150.13 20mg QQ客服:2056216494
    1,5-酐-D-山梨糖醇; 1,5-Anhydro-D-glucitol CFN90078 154-58-5 C6H12O5 = 164.16 5mg QQ客服:1457312923
    果糖; Fructose CFN98121 57-48-7 C6H12O6 = 180.16 20mg QQ客服:1413575084
    1,2-O-异亚丙基-beta-D-吡喃果糖; 1,2-O-Isopropylidene-beta-D-fructopyranose CFN97141 66900-93-4 C9H16O6 = 220.2 5mg QQ客服:1457312923
    1,2:4,5-Di-O-isopropylidene-beta-D-fructopyranose; 1,2:4,5-Di-O-isopropylidene-beta-D-fructopyranose CFN98273 25018-67-1 C12H20O6 = 260.3 5mg QQ客服:3257982914
    α-鼠李糖; alpha-L-Rhamnose CFN90450 3615-41-6 C6H12O5 = 164.16 20mg QQ客服:215959384
    鼠李糖; L-Rhamnose CFN99545 6155-35-7 C6H14O6 = 182.17 20mg QQ客服:1457312923
    D-(+)岩藻糖; D-(+)-Fucose CFN90954 3615-37-0 C6H12O5 = 164.16 20mg QQ客服:1413575084
    D(+)-无水葡萄糖; D-(+)-Glucose CFN99769 50-99-7 C6H12O6 = 180.16 20mg QQ客服:3257982914
    葡萄糖醛酸; Glucuronic acid CFN91487 6556-12-3 C6H10O7 = 194.1 20mg QQ客服:2056216494

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