山奈酚葡萄糖醛酸苷

Kaempferol-3-beta-O-glucuronide

	产品编号	CFN90359
	CAS编号	22688-78-4
	分子式 = 分子量	C₂₁H₁₈O₁₂ = 462.36
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Flavonoids
	植物来源	The herbs of Euphorbia lathyris
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
山奈酚葡萄糖醛酸苷	CFN90359	22688-78-4	1mg	QQ客服：215959384
山奈酚葡萄糖醛酸苷	CFN90359	22688-78-4	5mg	QQ客服：215959384
山奈酚葡萄糖醛酸苷	CFN90359	22688-78-4	10mg	QQ客服：215959384
山奈酚葡萄糖醛酸苷	CFN90359	22688-78-4	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Copenhagen University (Denmark)

Hamdard University (India)

Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

Chang Gung University (Taiwan)

University of Leipzig (Germany)

Charles Sturt University (Denmark)

Sanford Burnham Prebys Medical Discovery Institute (USA)

Mendel University in Brno (Czech Republic)

Tohoku University (Japan)

Universidade Federal de Pernambuco (UFPE) (Brazil)

Calcutta University (India)

Aarhus University (Denmark)

Utah State University (USA)

Weizmann Institute of Science (Israel)

More...

Description:

Kaempferol-3-beta-O-glucuronide has antioxidant activity. Flavonoid glucuronides can be deconjugated by microsomal β-glucuronidase from various human cells.

In vitro:

Z Naturforsch C. 2007 Sep-Oct;62(9-10):656-60.

Evaluation of cytotoxic compounds from calligonum comosum L. growing in Egypt.[Pubmed: 18069236]

METHODS AND RESULTS:
Calligonum comosum (Polygonaceae), an Egyptian desert plant, was extracted and fractionated using petroleum ether, methylene chloride, and ethyl acetate. The total methanolic extract and other fractions were tested for their anticancer activity using Ehrlich ascites, brine shrimp and antioxidant assays. Ethyl acetate fraction proved to be the most active in all assays. Eight compounds were isolated, purified, and identified from this fraction as (+)-catechin (1), dehydrodicatechin A (2), kaempferol-3-O-rhamnopyranoside (3), quercitrin (quercetin-3-O-rhamnopyranoside) (4), beta-sitosterol-3-O-glucoside (5), isoquercitrin (quercetin-3-O-glucopyranoside) (6), kaempferol-3-O-glucuronide (Kaempferol-3-beta-O-glucuronide,7), and mequilianin (quercetin-3-O-glucuronide) (8).
CONCLUSIONS:
All isolated compounds were tested for their cytotoxicity and antioxidant activity. Compound 2 showed the best cytotoxic and antioxidant activity.

In vivo:

Int Immunopharmacol . 2018 Apr;57:62-71.

Kaempferol-3-o-β-d-glucuronate exhibit potential anti-inflammatory effect in LPS stimulated RAW 264.7 cells and mice model[Pubmed: 29475097]

Abstract Kaempferol-3-O-β-d-glucuronide (K3G) having various pharmacological effects was explored for its anti-inflammatory effect in LPS induced RAW 264.7 cells and mice model. K3G significantly inhibited various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. It upregulated the secretion of anti-inflammatory cytokine IL-10. K3G is found to reduce inflammation when studied for parameters like phagocytic index, carrageenan induced paw edema in mice and organ weight. It reduced inflammation in a dose dependent manner both in-vitro and in-vivo. Further molecular insights into the study reveal that K3G blocks the phosphorylation of NF-kB which is key regulator of inflammation, thereby exhibiting anti-inflammatory potential. Hence, this study permits further investigation to develop K3G as anti-inflammatory drug. Keywords: Anti-inflammatory; Histopathology; Pathway elucidation; Proinflammatory.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
银椴苷；椴树苷; Tiliroside	CFN98026	20316-62-5	C₃₀H₂₆O₁₃ = 594.5	20mg	QQ客服：1413575084
顺式银椴苷; cis-Tiliroside	CFN92265	163956-16-9	C₃₀H₂₆O₁₃ = 594.5	5mg	QQ客服：1413575084
山奈酚-3-O-(2',6'-二-O-反式-对-香豆酰基)-beta-D-吡喃葡萄糖苷; Kaempferol-3-O-(2',6'-di-O-trans-p-coumaroyl)-beta-D-glucopyranoside	CFN92386	121651-61-4	C₃₉H₃₂O₁₅ = 740.7	5mg	QQ客服：1413575084
3'',4''-Di-O-acetyl-2'',6''-di-O-p-coumaroylastragalin; 3'',4''-Di-O-acetyl-2'',6''-di-O-p-coumaroylastragalin	CFN96315	137018-33-8	C₄₃H₃₆O₁₇ = 824.8	5mg	QQ客服：1413575084
3'',4''-二乙酰基-2'',6''-对-香豆酰氧基二紫芸英苷; 3'',4''-Di-O-acetyl-2'',6''-di-O-p-coumaroylastragalin	CFN96530	349545-02-4	C₄₃H₃₆O₁₇ = 824.74	5mg	QQ客服：1413575084
5''-O-乙酰基胡桃苷; 5''-O-Acetyljuglanin	CFN96533	885697-82-5	C₂₂H₂₀O₁₁ = 460.39	5mg	QQ客服：3257982914
2''-O-对香豆酰胡桃苷; 2''-O-Coumaroyljuglanin	CFN96261	67214-05-5	C₂₉H₂₄O₁₂ = 564.5	5mg	QQ客服：2056216494
堪非醇3-O-阿拉伯糖苷; Kaempferol 3-O-arabinoside	CFN97572	99882-10-7	C₂₀H₁₈O₁₀ = 418.4	5mg	QQ客服：3257982914
阿福豆苷; Afzelin	CFN98757	482-39-3	C₂₁H₂₀O₁₀ = 432.4	20mg	QQ客服：215959384
2'',4''-二-O-(E-对香豆酰)阿福豆甙; 2'',4''-Di-O-(E-p-coumaroyl)afzelin	CFN96246	163434-73-9	C₃₉H₃₂O₁₄ = 724.7	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1628 mL	10.8141 mL	21.6282 mL	43.2563 mL	54.0704 mL
5 mM	0.4326 mL	2.1628 mL	4.3256 mL	8.6513 mL	10.8141 mL
10 mM	0.2163 mL	1.0814 mL	2.1628 mL	4.3256 mL	5.407 mL
50 mM	0.0433 mL	0.2163 mL	0.4326 mL	0.8651 mL	1.0814 mL
100 mM	0.0216 mL	0.1081 mL	0.2163 mL	0.4326 mL	0.5407 mL