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  • 莰非醇-3,7,4'-三甲醚

    Kaempferol 3,7,4'-trimethylether

    莰非醇-3,7,4'-三甲醚
    产品编号 CFN96191
    CAS编号 15486-34-7
    分子式 = 分子量 C18H16O6 = 328.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The rhizomes of Curcuma aromatica.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    莰非醇-3,7,4'-三甲醚 CFN96191 15486-34-7 10mg QQ客服:3257982914
    莰非醇-3,7,4'-三甲醚 CFN96191 15486-34-7 20mg QQ客服:3257982914
    莰非醇-3,7,4'-三甲醚 CFN96191 15486-34-7 50mg QQ客服:3257982914
    莰非醇-3,7,4'-三甲醚 CFN96191 15486-34-7 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of South Australia (Australia)
  • Heidelberg University (Germany)
  • Chang Gung University (Taiwan)
  • University of Pretoria (South Africa)
  • Seoul National University of Science and Technology (Korea)
  • Univerzita Karlova v Praze (Czech Republic)
  • Calcutta University (India)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • University of Bonn (Germany)
  • Julius Kühn-Institut (Germany)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Universidade do Porto (Portugal)
  • University of British Columbia (Canada)
  • University of Padjajaran (Indonesia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Sci Nutr.2019, 8(1):246-256
  • Korean Journal of Medicinal Crop Science2018, 26(5):382-390
  • Phytomedicine.2019, 61:152813
  • Int J Biol Macromol.2020, 161:1230-1239.
  • Int J Pharm.2022, 618:121636.
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • Phytomedicine.2021, 2(82):153452
  • J Nat Med.2018, 72(3):734-744
  • J Nat Prod.2023, 86(2):264-275.
  • FASEB J.2019, 33(8):9685-9694
  • Food Res Int.2020, 128:108778
  • Nutrients.2020, 12(11):3448.
  • Natural Product Communications2020, doi: 10.1177.
  • Chem Biol Interact.2022, 368:110248.
  • Mol Pharmacol.2021, 99(2):163-174.
  • J of Dentistry & Oral Health2019, 2641-1962
  • Processes2020, 8(12),1540.
  • LWT-Food Science and Technology2017, 75:488-496
  • J Chromatogr A.2022, 1685:463640.
  • Int J Mol Sci.2015, 16(8):18396-411
  • Appl. Sci. 2021, 11(22), 10552
  • J Cachexia Sarcopenia Muscle.2022, 13(6):3149-3162.
  • Sci Rep.2023, 13(1):14594.
  • ...
  • 生物活性
    Description: Kaempferol 3,7,4'-trimethylether shows selective cyctoxic activities against the nine tested cancer cell lines.
    Targets: NO
    In vitro:
    BMC Complement Altern Med. 2014 Sep 19;14:340.
    Cytotoxicity of four Aframomum species (A. arundinaceum, A. alboviolaceum, A. kayserianum and A. polyanthum) towards multi-factorial drug resistant cancer cell lines.[Pubmed: 25239700 ]
    The search for natural products as potential cytotoxic agents has yielded promising candidates. However multidrug resistance (MDR) is still a major hurdle for patients receiving chemotherapy. In the present study, we evaluated the cytotoxicity of the methanol extracts of four dietary Aframomum plant species (A. arundinaceum, A. alboviolaceum, A. kayserianum and A. polyanthum) against nine sensitive and MDR cancer cell lines. We have also identified the bioactive constituents of A. arundinaceum.
    METHODS AND RESULTS:
    The cytotoxicity of the methanol extracts of the above plants was determined using a resazurin reduction assay. Chromatographic techniques were used to isolate the constituents of A. arundinaceum. A preliminary experiment on leukemia CCRF-CEM cells at 40 μg/mL showed that the extracts from A. kayserianum and A. alboviolaceum as well as the isolated compounds namely compounds aframodial (1), 8(17),12-labdadien-15,16-dial (2), galanolactone (3), 1-p-menthene-3,6-diol (6) and 1,4-dimethoxybenzene (7) were less active, inducing more than 50% growth of this cell line contrary to A. polyanthum and A. arundinaceum extracts, galanals A (4) and B (5), naringenin (8) and Kaempferol 3,7,4'-trimethylether (9). The IC50 values below or around 30 μg/mL were recorded with A. arundinaceum extract against eight of the nine tested cancer cell lines. This extract as well as compound 8 displayed IC50 values below 40 μg/mL towards the nine tested cancer cell lines whilst A. polyanthum extract, compounds 4, 5 and 9 showed selective activities. Collateral sensitivity (hypersensitivity) was observed with A. arundinaceum extract towards leukemia CEM/ADR5000 cells and glioblastoma U87MG.ΔEGFR compared to their respective sensitive counterparts CEM/CEM and U87MG.
    CONCLUSIONS:
    The results of this study provide evidence of the cytotoxicity selected Aframomum species as well as a baseline information for the potential use of Aframomum arundinaceum in the fight against drug sensitive and otherwise drug-resistant cancers.
    Songklanakarin Journal of Science and Technology, 2013, 35,(3): 317-23.
    Inhibition of nitric oxide production by compounds from Boesenbergia longiflora using lipopolysaccharide-stimulated RAW264.7 macrophage cells[Reference: WebLink]

    METHODS AND RESULTS:
    The inhibitory activity of extract and compounds isolated from Boesenbergia longiflora against nitric oxide (NO) was evaluated using RAW264.7 cells. Isolation of the chloroform extract of B. longiflora rhizomes afforded four known flavonoids, which were identified as Kaempferol 3,7,4'-trimethylether (1), kaempferol-7,4'-dimethyl ether (2), rhamnazin (3), pinostrobin (4), together with four known diarylheptanoids, dihydrobisdemethoxycurcumin (5), curcumin (6), demethoxycurcumin (7) and bisdemethoxycurcumin (8), as well as one sterol, -sitosterol-D-glucoside (9). Compound 6 exhibited the highest inhibitory activity against NO release with an IC50 value of 4.5 μM, followed by 7 (IC50 = 11.7 μM), 8 (IC50 = 15.7 μM), 5 (IC50 = 23.0 μM) and 1 (IC50 = 23.5 μM), respectively.
    CONCLUSIONS:
    This study demonstrated that diarylheptanoids and some methoxyflavonoids found in B. longiflora are responsible for anti-inflammatory activity and this is the first report the safety, chemical constituents and biological activity of this plant.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.046 mL 15.23 mL 30.4599 mL 60.9199 mL 76.1499 mL
    5 mM 0.6092 mL 3.046 mL 6.092 mL 12.184 mL 15.23 mL
    10 mM 0.3046 mL 1.523 mL 3.046 mL 6.092 mL 7.615 mL
    50 mM 0.0609 mL 0.3046 mL 0.6092 mL 1.2184 mL 1.523 mL
    100 mM 0.0305 mL 0.1523 mL 0.3046 mL 0.6092 mL 0.7615 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
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    芦替菌素; Luteosporin CFN98567 2530-39-4 C28H18O12 = 546.44 5mg QQ客服:2159513211
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    咖啡酸羽扇豆醇酯; Lupeol caffeate CFN99057 103917-26-6 C39H56O4 = 588.9 5mg QQ客服:215959384
    顺-6-十八碳烯酸; Petroselinic acid CFN70158 593-39-5 C18H34O2 = 282.4 20mg QQ客服:3257982914

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