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  • 酸枣仁皂苷B

    Jujuboside B

    酸枣仁皂苷B
    产品编号 CFN98102
    CAS编号 55466-05-2
    分子式 = 分子量 C52H84O21 = 1045.22
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Triterpenoids
    植物来源 The seeds of Ziziphus jujuba
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    酸枣仁皂苷B CFN98102 55466-05-2 10mg QQ客服:1413575084
    酸枣仁皂苷B CFN98102 55466-05-2 20mg QQ客服:1413575084
    酸枣仁皂苷B CFN98102 55466-05-2 50mg QQ客服:1413575084
    酸枣仁皂苷B CFN98102 55466-05-2 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Católica Portuguesa (Portugal)
  • Texas A&M University (USA)
  • University of Zurich (Switzerland)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • John Innes Centre (United Kingdom)
  • Univerzita Karlova v Praze (Czech Republic)
  • Almansora University (Egypt)
  • National Cancer Center Research Institute (Japan)
  • Universidade Federal de Goias (UFG) (Brazil)
  • The Australian National University (Australia)
  • University of Melbourne (Australia)
  • Helmholtz Zentrum München (Germany)
  • University of Wisconsin-Madison (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2019, 24(20):3755
  • Univerzita Karlova2022, 173245.
  • Molecules.2022, 27(21):7514.
  • Cell Biochem Funct.2018, 36(6):303-311
  • Int J Mol Sci.2020, 21(9):3392.
  • BioResources J.2020, 15(3).
  • Am J Chin Med.2015, 30:1-22
  • BMC Complement Altern Med.2014, 14:352
  • Phytomedicine.2015, 22(4):498-503
  • Chin. Med.J.Res. Prac.2017, 31(4)
  • Drug Des Devel Ther.2020, 14:969-976.
  • Horticulture Research2022, uhac276.
  • Life Sci.2019, 216:259-270
  • J Med Food.2022, 25(3):272-280.
  • J Chromatogr Sci.2015, 53(5):824-9
  • Appl. Sci. 2021, 11(22),10569
  • Molecules.2021, 26(8):2161.
  • Pharmacol Rep.2019, 71(2):289-298
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • Advances in Traditional Medicine 2021, 21:779-789.
  • Int J Mol Sci.2022, 23(23):14826.
  • Food Addit Contam Part A Chem Anal Control Expo Risk Assess.2020, 37(9):1437-1448.
  • Int. J. of Food Properties2017, S108-S118
  • ...
  • 生物活性
    Description: Jujuboside B has antitumor activity and the underlying mechanism via induction of apoptosis and autophagy. It reduces vascular tension endothelium-dependently by increasing Ca2+Influx and activating endothelial nitric oxide synthase, it has pharmacological effects on improving endothelial dysfunction and treating vascular diseases.
    Targets: Caspase | JNK | p38MAPK | Autophagy | NO | NOS | Calcium Channel
    In vitro:
    PLoS One. 2016 Feb 22;11(2):e0149386.
    Jujuboside B Reduces Vascular Tension by Increasing Ca2+ Influx and Activating Endothelial Nitric Oxide Synthase.[Pubmed: 26901291 ]
    Jujuboside B has been reported to have protective effect on many cardiovascular diseases. However, the effects of Jujuboside B on vascular tension and endothelial function are unknown. The present study investigated the effects of Jujuboside B on reducing vascular tension, protecting endothelial function and the potential mechanisms.
    METHODS AND RESULTS:
    The tension of isolated rat thoracic aorta ring was measured by Wire myograph system. The concentration of nitric oxide (NO) and the activity of endothelial nitric oxide synthase (eNOS) in human aortic endothelial cells (HAECs) were determined by Griess reagent method and enzyme-linked immune sorbent assay. The protein levels of eNOS and p-eNOS at Serine-1177 were determined by western blot analysis. Intracellular Ca2+ concentration in HAECs was measured by laser confocal imaging microscopy. Results showed that Jujuboside B reduced the tension of rat thoracic aorta rings with intact endothelium in a dose-dependent manner. L-NAME, KN93, EGTA, SKF96365, iberiotoxin and glibenclamide significantly attenuated Jujuboside B-induced vasodilation in endothelium-intact tissues. In contrast, indometacin and 4-DAMP had no such effects. Jujuboside B also promoted NO generation and increased eNOS activity, which were attenuated by L-NAME, EGTA and SKF96365. Moreover, Jujuboside B increased intracellular Ca2+ concentration dose-dependently, which was inhibited by EGTA and SKF96365. Besides, Jujuboside B induced a rapid Ca2+ influx instantaneously after depleting intracellular Ca2+ store, which was significantly inhibited by SKF96365.
    CONCLUSIONS:
    In conclusion, this study preliminarily confirmed that Jujuboside B reduced vascular tension endothelium-dependently. The underlying mechanisms involved that Jujuboside B increased extracellular Ca2+ influx through endothelial transient receptor potential cation (TRPC) channels, phosphorylated eNOS and promoted NO generation in vascular endothelial cells. In addition, Jujuboside B-induced vasodilation involved endothelium-dependent hyperpolarizaiton through endothelial potassium channels. Jujuboside B is a natural compound with new pharmacological effects on improving endothelial dysfunction and treating vascular diseases.
    In vivo:
    Phytother Res. 2013 Jun;27(6):829-34.
    Zizyphus jujuba and its active component jujuboside B inhibit platelet aggregation.[Pubmed: 22893618]
    The seeds of Zizyphus jujuba (SZJ), a famous oriental traditional medicine, have been reported to exhibit diverse activities in biological systems including the cardiovascular system. However, little information is available on its antiplatelet activity. This study was undertaken to investigate the antiplatelet effects of the ethanolic extract of SZJ (ESZJ) and of its principal components jujuboside A and Jujuboside B.
    METHODS AND RESULTS:
    In the in vitro platelet aggregation study, ESZJ exhibited significant and concentration-dependent inhibitory effects on collagen-, thrombin-, and AA-induced platelet aggregation. In addition, ESZJ-treated mice showed significantly the prolongation of bleeding times and the protection against thromboembolic attack. A comparison of the effects of jujuboside A and Jujuboside B on platelet aggregation revealed that only Jujuboside B had potent inhibitory effects on collagen-, thrombin-, AA-, and ADP-induced aggregation. Jujuboside B also exhibited superior protection on thromboembolic model. Furthermore, Jujuboside B had a significant inhibitory effect on collagen-induced thromboxane A2 production in rat platelets.
    CONCLUSIONS:
    This study describes the antiplatelet effects of ESZJ and of its active component Jujuboside B, and its findings suggest that these agents be considered as components of preventive and therapeutic herbal drugs targeting cardiovascular diseases associated with platelet hyperaggregation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9567 mL 4.7837 mL 9.5674 mL 19.1347 mL 23.9184 mL
    5 mM 0.1913 mL 0.9567 mL 1.9135 mL 3.8269 mL 4.7837 mL
    10 mM 0.0957 mL 0.4784 mL 0.9567 mL 1.9135 mL 2.3918 mL
    50 mM 0.0191 mL 0.0957 mL 0.1913 mL 0.3827 mL 0.4784 mL
    100 mM 0.0096 mL 0.0478 mL 0.0957 mL 0.1913 mL 0.2392 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    酸枣仁皂苷B; Jujuboside B CFN98102 55466-05-2 C52H84O21 = 1045.22 20mg QQ客服:215959384
    酸枣仁皂苷A; Jujuboside A CFN98101 55466-04-1 C58H94O26 = 1207.35 20mg QQ客服:2056216494
    酸枣仁皂苷D; Jujuboside D CFN98103 194851-84-8 C58H94O26 = 1207.35 10mg QQ客服:1413575084

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