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  • 胡桃酮,5-羟基对萘醌

    Juglone

    胡桃酮,5-羟基对萘醌
    产品编号 CFN90497
    CAS编号 481-39-0
    分子式 = 分子量 C10H6O3 = 174.16
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Quinones
    植物来源 The barks of Juglans regia L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    胡桃酮,5-羟基对萘醌 CFN90497 481-39-0 10mg QQ客服:1413575084
    胡桃酮,5-羟基对萘醌 CFN90497 481-39-0 20mg QQ客服:1413575084
    胡桃酮,5-羟基对萘醌 CFN90497 481-39-0 50mg QQ客服:1413575084
    胡桃酮,5-羟基对萘醌 CFN90497 481-39-0 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad Miguel Hernández (Spain)
  • Mahidol University (Thailand)
  • Universidad de Antioquia (Colombia)
  • University of Minnesota (USA)
  • Medizinische Universit?t Wien (Austria)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Kyushu University (Japan)
  • Center for protein Engineering (CIP) (Belgium)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Lodz University of Technology (Poland)
  • Gyeongsang National University (Korea)
  • Universitas islam negeri Jakarta (Indonesia)
  • Wroclaw Medical University (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Journal of Functional Foods2022, 99: 105331.
  • Journal of Ginseng Research2021, 25 November
  • Kaohsiung J Med Sci.2023, 10.1002/kjm2.12764
  • Molecules.2019, 24(23):E4303
  • Phytother Res.2022, ptr.7573.
  • Molecules.2018, 23(7):E1659
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • Iranian J. Pharm. Res.2021, 20(4):59-70
  • Clin Transl Oncol.2019, 10.1007
  • Molecules.2020, 25(18):4283.
  • Toxins (Basel).2019, 11(10):E575
  • Front Cell Dev Biol.2020, 8:32.
  • Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112
  • Mol Immunol. 2016, 78:121-132
  • PLoS One.2018, 13(4):e0195642
  • Plants (Basel).2021, 10(6):1192.
  • Appl. Sci.2020, 10(4),1304
  • J. of Agricultural Science2015, 1916-9760
  • Food Structure2023, 36:100324.
  • Plant Pathology2022, 13527
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • Nutrients.2019, 11(4):E936
  • Journal of Plant Growth Regulation2022, 10705-2.
  • ...
  • 生物活性
    Description: Juglone has anti-inflammatory, and anti-cancer activities, it can significantly inhibit the proliferation and induce the apoptosis of SiHa cells and Caski cells; it prevents high-fat diet-induced liver injury and nerve inflammation in mice through inhibition of inflammatory cytokine secretion, NF-kappa B activation and endotoxin production. Juglone stimulates suicidal erythrocyte death or eryptosis at least in part by upregulation of ceramide abundance, energy depletion and activation of PKC.
    Targets: Calcium Channel | PKC | TLR | NF-kB | TNF-α | IL Receptor | Bcl-2/Bax
    In vitro:
    Basic Clin Pharmacol Toxicol. 2015 Jun;116(6):460-7.
    Enhanced eryptosis following juglone exposure.[Pubmed: 25348830 ]
    Juglone, a quinone isolated from Juglans mandshurica Maxim, has previously been shown to be effective against malignancy. The effect is at least partially due to stimulation of suicidal death or apoptosis of tumour cells. On the other hand, Juglone has been shown to counteract apoptosis, for example, of neurons. In analogy to apoptosis of nucleated cells, erythrocytes may enter eryptosis, a suicidal death characterized by cell shrinkage and breakdown of phosphatidylserine asymmetry of the cell membrane with phosphatidylserine exposure at the erythrocyte surface. Stimulators of eryptosis include increase in cytosolic Ca(2+) activity [(Ca(2+) )i ].
    METHODS AND RESULTS:
    This study explored whether Juglone stimulates eryptosis. To this end, erythrocyte volume was estimated from forward scatter, phosphatidylserine exposure at the erythrocyte surface from FITC annexin V binding, ceramide abundance from binding of fluorescent antibodies in flow cytometry and cytosolic ATP with a luciferin-luciferase-based assay. As a result, a 24-hr exposure of human erythrocytes to Juglone (5 μM) significantly decreased erythrocyte forward scatter. Juglone (1-5 μM) significantly increased the percentage of annexin V binding cells. Juglone (5 μM) significantly increased ceramide abundance at the erythrocyte surface and decreased erythrocyte ATP concentration. The effect of Juglone (10 μM) on annexin V binding was slightly but significantly blunted by removal of extracellular Ca(2+) and by addition of protein kinase C (PKC) inhibitor staurosporine (1 μM).
    CONCLUSIONS:
    In conclusion, Juglone stimulates suicidal erythrocyte death or eryptosis at least in part by upregulation of ceramide abundance, energy depletion and activation of PKC.
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015 Feb;31(2):186-9.
    Juglone inhibits proliferation and induces apoptosis of human cervical squamous cancer SiHa cells[Pubmed: 25652859]
    To explore the effect of Juglone on proliferation and apoptosis of human cervical squamous cancer SiHa cells.
    METHODS AND RESULTS:
    Cultured SiHa cells in the exponential growth phase were grouped into blank control group and 10, 20, 50, 80 and 100 μmol/L Juglone treatment groups. Methyl thiazolyl tetrazolium (MTT) assay was adopted to observe the inhibitory effect of Juglone on the proliferation of SiHa cells, and then 50% inhibitory concentration (IC50) was calculated through formula. Annexin V-FITC/PI double staining and flow cytometry were used to detect the effect of 20 μmol/L Juglone on SiHa cell apoptosis. Western blot was applied to determine the expressions of Bcl-2 and Bax. MTT assay showed that, compared with the control group, treatment groups all showed significant inhibitory effects on SiHa cell growth, and IC50 was 20.4 μmol/L. Flow cytometry demonstrated that early apoptosis rate of SiHa cells in the control group was (2.46 ± 0.37)%, and after treatment with 20 μmol/L Juglone for 12 hours, the apoptosis rate was raised to (18.47 ± 2.26)%; Western blot analysis showed that the expression of Bcl-2 decreased while the expression of Bax increased significantly in SiHa cells treated with 20 μmol/L Juglone.
    CONCLUSIONS:
    Juglone could significantly inhibit the proliferation and induce the apoptosis of SiHa cells.
    In vivo:
    Biochem Biophys Res Commun. 2015 Jul 3;462(3):245-50.
    Juglone prevents metabolic endotoxemia-induced hepatitis and neuroinflammation via suppressing TLR4/NF-κB signaling pathway in high-fat diet rats.[Pubmed: 25964086]
    Juglone as a natural production mainly extracted from green walnut husks of Juglans mandshurica has been defined as the functional composition among a series of compounds. It showed powerful protective effect in various diseases by inhibiting inflammation and tumor cells growth. However, studies on its anti-inflammatory effect based on high-fat diet-induced hepatitis and neuroinflammation are still not available.
    METHODS AND RESULTS:
    In this regard, we first investigated whether Juglone suppresses high-fat diet-stimulated liver injury, hypothalamus inflammation and underlying mechanisms by which they may recover them. SD rats were orally treated with or without high-fat diet, 0.25 mg/kg or 1 mg/kg Juglone for 70 days. Subsequently, blood, hypothalamus and liver tissue were collected for different analysis. Also, the primary astrocytes were isolated and used to analyze the inhibitory effect of Juglone in vitro. Analysis of inflammatory cytokines declared that the inhibition of TNF-α, IL-1β and IL-6 could be carried by Juglone in response to high-fat diet rats. Meanwhile, TLR4 expression and NF-kappa activity also have been confirmed to be the key link in the development of hepatitis and nerve inflammation. The activation was significantly suppressed in treatment group as compared with model.
    CONCLUSIONS:
    These results indicated that Juglone prevents high-fat diet-induced liver injury and nerve inflammation in mice through inhibition of inflammatory cytokine secretion, NF-kappa B activation and endotoxin production.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.7418 mL 28.7092 mL 57.4185 mL 114.8369 mL 143.5462 mL
    5 mM 1.1484 mL 5.7418 mL 11.4837 mL 22.9674 mL 28.7092 mL
    10 mM 0.5742 mL 2.8709 mL 5.7418 mL 11.4837 mL 14.3546 mL
    50 mM 0.1148 mL 0.5742 mL 1.1484 mL 2.2967 mL 2.8709 mL
    100 mM 0.0574 mL 0.2871 mL 0.5742 mL 1.1484 mL 1.4355 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    兰雪醌; Plumbagin CFN90444 481-42-5 C11H8O3 = 188.17 20mg QQ客服:2159513211
    梅笠草素; Chimaphilin CFN95676 482-70-2 C12H10O2 = 186.2 20mg QQ客服:2056216494
    7-(Hydroxymethyl)-2-methyl-1,4-naphthalenedione; 7-(Hydroxymethyl)-2-methyl-1,4-naphthalenedione CFN95672 145626-36-4 C12H10O3 = 202.2 10mg QQ客服:2159513211
    新化合物33; New compound 33 CFN95706 N/A C18H20O8 = 364.4 5mg QQ客服:2159513211
    茅膏醌; Droserone CFN91989 478-40-0 C11H8O4 = 204.18 5mg QQ客服:1413575084
    马兜铃对酮; Aristolindiquinone CFN93018 86533-36-0 C12H10O4 = 218.20 5mg QQ客服:215959384
    2-甲氧基-6-乙酰基-7-甲基胡桃酮; 2-Methoxystypandrone CFN97412 85122-21-0 C14H12O5 = 260.2 5mg QQ客服:215959384
    钩毛茜草素 C; Rubioncolin C CFN89245 132242-52-5 C27H22O6 = 442.46 5mg QQ客服:3257982914
    3,3'-Bilawsone; 3,3'-Bilawsone CFN92932 33440-64-1 C20H10O6 = 346.29 5mg QQ客服:1457312923
    异柿醌; Isodiospyrin CFN98019 20175-84-2 C22H14O6 = 374.4 5mg QQ客服:1457312923

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