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  • 异地胆草种内酯

    Isoscabertopin

    异地胆草种内酯
    产品编号 CFN97740
    CAS编号 439923-16-7
    分子式 = 分子量 C20H22O6 = 358.39
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Elephantopus scaber L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异地胆草种内酯 CFN97740 439923-16-7 1mg QQ客服:3257982914
    异地胆草种内酯 CFN97740 439923-16-7 5mg QQ客服:3257982914
    异地胆草种内酯 CFN97740 439923-16-7 10mg QQ客服:3257982914
    异地胆草种内酯 CFN97740 439923-16-7 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Universiti Malaysia Pahang (Malaysia)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • University of Canterbury (New Zealand)
  • Gyeongsang National University (Korea)
  • Korea Food Research Institute(KFRI) (Korea)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Monash University Malaysia (Malaysia)
  • University of the Basque Country (Spain)
  • Chang Gung University (Taiwan)
  • Medical University of South Carolina (USA)
  • Biotech R&D Institute (USA)
  • Sri Ramachandra University (India)
  • University of Wollongong (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • BMC Plant Biol.2020, 20(1):214.
  • Molecules.2021, 26(9):2765.
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Appl. Sci.2021, 11(1),14.
  • Data Science for Genomics2023, 107-128.
  • Applied Biological Chemistry2022, 65(85).
  • Biochem Biophys Res Commun.2020, 527(4):889-895.
  • Journal of Apiculture2019, 34(2):131-136
  • Horticulture Research2022, uhac276.
  • Hum Exp Toxicol.2023, 42:9603271221145386.
  • APMIS.2019, 127(10):688-695
  • J Mol Histol.2019, 50(4):343-354
  • J Sci Food Agric.2022, 102(4):1628-1639
  • Crystals2020, 10(3), 206.
  • J Adv Res.2021, 35:245-257.
  • J Nat Sc Biol Med2019, 10(2):149-156
  • Universidade Estadual Paulista2017, 11449
  • Molecules.2020, 25(15):3353.
  • Molecules.2018, 23(12):E3103
  • Molecules.2018, 23(10):E2638
  • Neurochem Int.2020, 133:104629
  • Molecules.2019, 24(16):E2985
  • ...
  • 生物活性
    Description: Isoscabertopin has anticancer activity.
    In vitro:
    Nat Prod Res. 2014;28(11):819-30.
    A review on pharmacology and toxicology of Elephantopus scaber Linn.[Pubmed: 24499355]

    METHODS AND RESULTS:
    Elephantopus scaber Linn., family Asteraceae, is a small herb found in the Neotropics, Europe, Asia, Africa and Australia. The parts of this plant have been used traditionally for the treatment of number of diseases in many countries. The plant has been extensively screened for anticancer activity. Sesquiterpene lactones such as deoxyelephantopin, isodeoxyelephantopin, scabertopin and Isoscabertopin. have been found to be prominent anticancer constituents.
    CONCLUSIONS:
    Many other biological activities such as antimicrobial, hepatoprotective, antioxidant, antidiabetic, anti-inflammatory, analgesic, antiasthamatic, antiplatelet and wound healing ability have been reported in various research articles. This review has been envisaged with an intention to provide the scientific information about the pharmacological and toxicological profile of E. scaber.
    Exp Oncol. 2006 Jun;28(2):106-9.
    Antitumor activities of the four sesquiterpene lactones from Elephantopus scaber L.[Pubmed: 16837899]
    To evaluate antitumor activity of sesquiterpene lactones (scabertopin (ES-2), Isoscabertopin (ES-3), deoxyelephantopin (ES-4), isodeoxyelephantopin (ES-5)) isolated from Elephantopus scaber L. in vitro and in vivo.
    METHODS AND RESULTS:
    SMMC-7721, Caco-2 and HeLa cell lines were treated with ES-2,3,4,5. Cell viability was determined by MTT assay. Agarose gel electrophoresis was used to detect DNA fragmentation. To evaluate in vivo antitumor activity of ES-4, experimental murine tumor model was used. It was shown that ES-2, ES-4, ES-5 exhibited significant antitumor effect in vitro in a concentration-dependent manner. However, the effect of Isoscabertopin on the growth of tested cell lines was relatively weak. In HeLa cells exposed to ES-4 for 48 h, morphological changes and DNA ladder pattern evidencing on apoptosis were detected.
    CONCLUSIONS:
    ES-4 revealed in vivo antitumor activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7903 mL 13.9513 mL 27.9026 mL 55.8051 mL 69.7564 mL
    5 mM 0.5581 mL 2.7903 mL 5.5805 mL 11.161 mL 13.9513 mL
    10 mM 0.279 mL 1.3951 mL 2.7903 mL 5.5805 mL 6.9756 mL
    50 mM 0.0558 mL 0.279 mL 0.5581 mL 1.1161 mL 1.3951 mL
    100 mM 0.0279 mL 0.1395 mL 0.279 mL 0.5581 mL 0.6976 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    8beta-(4'-Hydroxytigloyloxy)costunolide; 8beta-(4'-Hydroxytigloyloxy)costunolide CFN92903 94190-32-6 C20H26O5 = 346.42 5mg QQ客服:2056216494
    Neobritannilactone B; Neobritannilactone B CFN92602 886990-00-7 C15H20O3 = 248.3 5mg QQ客服:3257982914
    2alpha-羟基泽兰内酯; 2-Hydroxyeupatolide CFN90346 72229-33-5 C15H20O4 = 264.32 5mg QQ客服:1413575084
    表美国鹅掌楸内酯; Epitulipinolide CFN98252 24164-13-4 C17H22O4 = 290.4 5mg QQ客服:215959384
    小白菊内酯; Parthenolide CFN98034 20554-84-1 C15H20O3 = 248.3 20mg QQ客服:3257982914
    鹅掌揪内酯; Lipiferolide CFN98642 41059-80-7 C17H22O5 = 306.4 5mg QQ客服:1413575084
    环氧表美国鹅掌楸内酯; Epitulipinolide diepoxide CFN98630 39815-40-2 C17H22O6 = 322.4 5mg QQ客服:2159513211
    Heliangin; Heliangin CFN96222 13323-48-3 C20H26O6 = 362.4 5mg QQ客服:2159513211
    8beta-(4-Hydroxytigloyloxy)ovatifolin; 8beta-(4-Hydroxytigloyloxy)ovatifolin CFN96820 554449-27-3 C22H28O7 = 404.45 5mg QQ客服:2056216494
    Demethylsonchifolin; Demethylsonchifolin CFN97591 956384-55-7 C20H24O6 = 360.41 5mg QQ客服:3257982914

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