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  • 异肥皂草苷

    Isosaponarin

    异肥皂草苷
    产品编号 CFN90133
    CAS编号 19416-87-6
    分子式 = 分子量 C27H30O15 = 594.52
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The seeds of Vaccaria segetalis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异肥皂草苷 CFN90133 19416-87-6 1mg QQ客服:1413575084
    异肥皂草苷 CFN90133 19416-87-6 5mg QQ客服:1413575084
    异肥皂草苷 CFN90133 19416-87-6 10mg QQ客服:1413575084
    异肥皂草苷 CFN90133 19416-87-6 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University Medical Center Mainz (Germany)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Universidad de Buenos Aires (Argentina)
  • University of Pretoria (South Africa)
  • University of Padjajaran (Indonesia)
  • University of South Australia (Australia)
  • Charles University in Prague (Czech Republic)
  • Mahatma Gandhi University (India)
  • Center for protein Engineering (CIP) (Belgium)
  • Texas A&M University (USA)
  • University of Bordeaux (France)
  • Max-Planck-Insitut (Germany)
  • Kyushu University (Japan)
  • Monash University Sunway Campus (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Chem.2017, 221:1135-1144
  • Environ Toxicol.2019, 34(12):1354-1362
  • J Agric Food Chem.2020, 68(51):15164-15175
  • J Nat Med.2018, 72(3):734-744
  • Molecules.2019, 24(9):E1719
  • Plos One.2019, 15(2):e0220084
  • Molecules.2019, 24(1):E159
  • Phytother Res.2018, 32(5):923-932
  • Neurochem Int.2020, 133:104629
  • Anal Biochem.2019, 569:10-15
  • Molecules.2019, 24(4):E744
  • Korean J. Crop Sci.2018, 63(2):131-139
  • Tropical Journal of Pharmaceutical Research 2021, 20(6):1165-1170.
  • Antiviral Res.2013, 98(3):386-93
  • J Ethnopharmacol.2017, 198:205-213
  • Food and Bioprocess Technology2017, 10(6):1074-1092
  • Molecules.2019, 24(6):E1177
  • Chemistry of Natural Compounds2018, 54(3):572-576
  • Sci Rep.2019, 9(1):4342
  • Yakugaku Zasshi.2018, 138(4):571-579
  • Processes2022, 10(10), 2008.
  • Industrial Crops and Products2019, 140:111612
  • Kangwon National University2022, 37(1):29-37
  • ...
  • 生物活性
    Description: Isosaponarin increases collagen synthesis in human fibroblasts, causes by up-regulated TbetaR-II and P4H production.
    Targets: TGF-β/Smad
    In vitro:
    J Nat Med. 2010 Jul;64(3):305-12.
    The effect of isosaponarin isolated from wasabi leaf on collagen synthesis in human fibroblasts and its underlying mechanism.[Pubmed: 20349148 ]
    Wasabi has been used as an important spice in Japanese foods. The wasabi leaves were used as a cosmetic material, but its biological activities have not yet been examined.
    METHODS AND RESULTS:
    We investigated the effect of Isosaponarin derived from wasabi leaf on collagen synthesis in human fibroblasts. The production of type I collagen in human fibroblasts was increased with treatment of wasabi leaf extract. Isosaponarin isolated from wasabi leaves belonged to the group of flavone glycoside, and was the key compound in collagen synthesis from the wasabi leaf ingredients. Isosaponarin increased the type I collagen production at the mRNA gene level. The treatment of Isosaponarin did not influence the production of transforming growth factor-beta (TGF-beta) protein, but increased the production of TGF-beta type II receptor (TbetaR-II) protein and TbetaR-II mRNA. Prolyl 4-hydroxylase (P4H) protein and P4H mRNA were increased by treatment with Isosaponarin. Heat shock protein 47 (HSP47) was not increased by treatment with Isosaponarin.
    CONCLUSIONS:
    These results suggested that Isosaponarin increased collagen synthesis in human fibroblasts, caused by up-regulated TbetaR-II and P4H production.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.682 mL 8.4101 mL 16.8203 mL 33.6406 mL 42.0507 mL
    5 mM 0.3364 mL 1.682 mL 3.3641 mL 6.7281 mL 8.4101 mL
    10 mM 0.1682 mL 0.841 mL 1.682 mL 3.3641 mL 4.2051 mL
    50 mM 0.0336 mL 0.1682 mL 0.3364 mL 0.6728 mL 0.841 mL
    100 mM 0.0168 mL 0.0841 mL 0.1682 mL 0.3364 mL 0.4205 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    牡荆素-4''-O-葡萄糖苷; Vitexin -4''-O-glucoside CFN92072 178468-00-3 C27H30O15 = 594.5 20mg QQ客服:1457312923
    异斯皮诺素; Isospinosin CFN95350 89701-83-7 C28H32O15 = 608.6 5mg QQ客服:3257982914
    芹菜素-6-C-α-L-阿拉伯糖-8-C-β-D-木糖苷; Apigenin 6-C-alpha-L-arabinopyranosyl-8-C-beta-D-xylopyranoside CFN90918 677021-30-6 C25H26O13 = 534.47 5mg QQ客服:1457312923
    芹菜素-6,8-二-C-α-L-吡喃阿拉伯糖苷; Apigenin 6,8-di-C-alpha-L-arabinopyranoside CFN95360 73140-47-3 C25H26O13 = 534.5 10mg QQ客服:3257982914
    维采宁-3; Vicenin -3 CFN92032 59914-91-9 C26H28O14 = 564.5 20mg QQ客服:1457312923
    夏佛塔苷; Schaftoside CFN90197 51938-32-0 C26H28O14 = 564.49 20mg QQ客服:215959384
    新夏佛托苷; Neoschaftoside CFN92071 61328-41-4 C26H28O14 = 564.5 5mg QQ客服:215959384
    维采宁-1; Vicenin -1 CFN92030 35927-38-9 C26H28O14 = 564.5 20mg QQ客服:2056216494
    伞花耳草苷; Corymboside CFN95292 73543-87-0 C26H28O14 = 564.5 10mg QQ客服:3257982914
    异夏佛塔苷; Isoschaftoside CFN92029 52012-29-0 C26H28O14 = 564.5 20mg QQ客服:215959384

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