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  • 异海松酸

    • 异海松酸

    Isopimaric acid

    异海松酸
    		产品编号 CFN97723
    CAS编号 5835-26-7
    分子式 = 分子量 C20H30O2 = 302.46
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The herbs of Daemonorops draco Blume
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异海松酸 CFN97723 5835-26-7 1mg QQ客服：2056216494
    异海松酸 CFN97723 5835-26-7 5mg QQ客服：2056216494
    异海松酸 CFN97723 5835-26-7 10mg QQ客服：2056216494
    异海松酸 CFN97723 5835-26-7 20mg QQ客服：2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
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  • National Cancer Center Research Institute (Japan)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Journal of Ginseng Research2021, 25 November
  • Plant Foods Hum Nutr.2020, 10.1007
  • Food Sci Nutr.2019, 8(1):246-256
  • Life Sci.2023, 317:121458.
  • Int J Mol Sci.2017, 18(5)
  • Russian J Bioorganic Chemistry 2021, 47:1411-1417.
  • Ann Transl Med.2019, 7(23):731
  • Front Pharmacol.2020, 11:683.
  • Biochem Biophys Res Commun.2020, 527(4):889-895.
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • Research Square2021, March 3rd.
  • Agronomy 2021, 11(3),502.
  • J Korean Med Ophthalmol Otolaryngol Dermatol2023, 36(1):1-20.
  • Anticancer Res.2014, 34(7):3505-9
  • Pharmacognosy Journal.2022, 14,4,327-337.
  • Mol Med Rep.2023 Oct;28(4):193.
  • Journal of Chromatography A2020, 460942
  • Nutrients.2017, 10(1)
  • Separations2021, 8(6),80.
  • Drug Test Anal.2018, 10(10):1579-1589
  • Phytomedicine.2021, 2(82):153452
  • Int J Mol Sci.2022, 23(23):15213.
  • Molecules2022, 27(12):3903.
  • ...
    • 生物活性
    Description: Isopimaric acid is active against MDR and MRSA strains of S. aureus which are becoming increasingly resistant to antibiotics, the minimum inhibitory concentrations (MIC) are 32-64 microg/mL . Isopimaric acid is also possible that an antagonistic interaction with reserpine may render the antibiotics inactive.
    Targets: Antifection
    In vitro:
    Phytother Res. 2005 Jun;19(6):538-42.
    Isopimaric acid from Pinus nigra shows activity against multidrug-resistant and EMRSA strains of Staphylococcus aureus.[Pubmed: 16114093]

    METHODS AND RESULTS:
    The diterpene Isopimaric acid was extracted from the immature cones of Pinus nigra (Arnold) using bioassay-guided fractionation of a crude hexane extract. Isopimaric acid was assayed against multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) were 32-64 microg/mL and compared with a commercially obtained resin acid, abietic acid, with MICs of 64 microg/mL. Resin acids are known to have antibacterial activity and are valued in traditional medicine for their antiseptic properties. These results show that Isopimaric acid is active against MDR and MRSA strains of S. aureus which are becoming increasingly resistant to antibiotics. Both compounds were evaluated for modulation activity in combination with antibiotics, but did not potentiate the activity of the antibiotics tested. However, the compounds were also assayed in combination with the efflux pump inhibitor reserpine, to see if inhibition of the TetK or NorA efflux pump increased their activity. Interestingly, rather than a potentiation of activity by a reduction in MIC, a two to four-fold increase in MIC was seen.
    CONCLUSIONS:
    It may be that Isopimaric acid and abietic acid are not substrates for these efflux pumps, but it is also possible that an antagonistic interaction with reserpine may render the antibiotics inactive. 1H-NMR of abietic acid and reserpine taken individually and in combination, revealed a shift in resonance of some peaks for both compounds when mixed together compared with the spectra of the compounds on their own. It is proposed that this may be due to complex formation between abietic acid and reserpine and that this complex formation is responsible for a reduction in activity and elevation of MIC.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3062 mL 16.5311 mL 33.0622 mL 66.1244 mL 82.6556 mL
    5 mM 0.6612 mL 3.3062 mL 6.6124 mL 13.2249 mL 16.5311 mL
    10 mM 0.3306 mL 1.6531 mL 3.3062 mL 6.6124 mL 8.2656 mL
    50 mM 0.0661 mL 0.3306 mL 0.6612 mL 1.3225 mL 1.6531 mL
    100 mM 0.0331 mL 0.1653 mL 0.3306 mL 0.6612 mL 0.8266 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    长白楤木酸; Continentalic acid CFN90861 19889-23-7 C20H30O2 = 302.5 20mg QQ客服：3257982914
    海松酸; Pimaric acid CFN99382 127-27-5 C20H30O2 = 302.5 5mg QQ客服：2159513211
    异海松酸; Isopimaric acid CFN97723 5835-26-7 C20H30O2 = 302.46 5mg QQ客服：1457312923
    玫瑰菌素; Rosenonolactone CFN98805 508-71-4 C20H28O3 = 316.4 5mg QQ客服：3257982914
    Orthosiphol A; Orthosiphol A CFN95442 142741-25-1 C38H44O11 = 676.8 5mg QQ客服：215959384
    Neoorthosiphol A; Neoorthosiphol A CFN95447 243448-72-8 C38H44O12 = 692.8 10mg QQ客服：2159513211
    15-异海松烯-8,18-二醇; 15-Isopimarene-8,18-diol CFN97214 73002-86-5 C20H34O2 = 306.5 5mg QQ客服：1413575084
    Toonaciliatin M; Toonaciliatin M CFN92899 93930-04-2 C20H32O3 = 320.47 5mg QQ客服：1413575084
    8(14),15-异海松二烯-3,18-二醇; 8(14),15-Isopimaradiene-3,18-diol CFN97003 59219-64-6 C20H32O2 = 304.5 5mg QQ客服：3257982914
    Hugorosenone; Hugorosenone CFN92876 217096-49-6 C20H30O2 = 302.4 5mg QQ客服：2056216494

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