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  • 异奥卡宁

    Isookanin

    异奥卡宁
    产品编号 CFN90850
    CAS编号 1036-49-3
    分子式 = 分子量 C15H12O6 = 288.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Bidens pilosa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异奥卡宁 CFN90850 1036-49-3 10mg QQ客服:215959384
    异奥卡宁 CFN90850 1036-49-3 20mg QQ客服:215959384
    异奥卡宁 CFN90850 1036-49-3 50mg QQ客服:215959384
    异奥卡宁 CFN90850 1036-49-3 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Warszawski Uniwersytet Medyczny (Poland)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • The University of Newcastle (Australia)
  • Mahidol University (Thailand)
  • Sant Gadge Baba Amravati University (India)
  • Agricultural Research Organization (ARO) (Israel)
  • Medical University of Gdansk (Poland)
  • Universidad de La Salle (Mexico)
  • University of Minnesota (USA)
  • University of Wisconsin-Madison (USA)
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  • Julius Kühn-Institut (Germany)
  • Harvard University (USA)
  • University Medical Center Mainz (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Journal of Plant Growth Regulation2022, 10705-2.
  • Viruses.2017, 9(10)
  • Agronomy 2021, 11(3),502.
  • Front Plant Sci.2020, 10:1705
  • Food Chem. 2020, 320:126530
  • Front Plant Sci.2018, 9:1424
  • Turk J Med Sci.2023 53: 1312-1320.
  • Sci Rep.2019, 9(1):4646
  • Sci Rep. 2017, 8207(7)
  • International Food Research Journal2018, 25(6):2560-2571
  • Oncotarget.2017, 8(64):108006-108019
  • TCI CO.2019, US20190151257A1
  • J Med Food.2022, 25(3):272-280.
  • J Biomol Struct Dyn.2022, 1-21.
  • Molecules.2019, 24(6):E1177
  • Phytomedicine.2019, 56:48-56
  • J Sep Sci.2018, 41(11):2488-2497
  • Evid Based Complement Alternat Med.2020, 2020:2584783.
  • Front Pharmacol.2021, 12:607403.
  • Mol Biol Rep.2022, doi: 10.1007
  • Molecules.2021, 26(9):2802.
  • Biomolecules.2020, 10(6):925.
  • Advances in Traditional Medicine2020, 10.1007
  • ...
  • 生物活性
    Description: Isookanin shows strong diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) radical-scavenging activity, with the IC50 value of 7.9 ± 0.53 uM. Isookanin is a potent inhibitor of α-amylase (IC₅₀=0.447 mg/ml).
    In vitro:
    J Agric Food Chem. 2015 Jan 14;63(1):200-7.
    New phenolic compounds from Coreopsis tinctoria Nutt. and their antioxidant and angiotensin i-converting enzyme inhibitory activities.[Pubmed: 25516207 ]
    Three new phenolic compounds, coretinphenol (1), coretincone (2), and coretinphencone (3), were isolated from the buds of Coreopsis tinctoria Nutt., together with nine known compounds, including butein (4), okanin (5), isoliquiritigenin (6), maritimetin (7), taxifolin (8), Isookanin (9), marein (10), sachalinoside B (11), and 2-phenylethyl-β-d-glucoside (12).
    METHODS AND RESULTS:
    The chemical structures of these compounds were elucidated by extensive spectroscopic analysis and on the basis of their chemical reactivity. This work represents the first recorded example of the isolation of compounds 1–3, 6, 7, 9, 11, and 12 from C. tinctoria. Compounds 5–9 showed strong diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) radical-scavenging activity, with IC50 values of 3.35 ± 0.45, 9.6 ± 2.32, 4.12 ± 0.21, 6.2 ± 0.43, and 7.9 ± 0.53 μM, respectively. Compounds 2 and 8 exhibited angiotensin I-converting enzyme inhibitory activity, with IC50 values of 228 ± 4.47 and 145.67 ± 3.45 μM, respectively.
    CONCLUSIONS:
    The activities of phenolic compounds isolated from C. tinctoria support the medicinal use of this plant in the prevention of cardiovascular diseases.
    In vivo:
    Molecules . 2020 Jun 5;25(11):2631.
    Subacute Oral Administration of Clinacanthus nutans Ethanolic Leaf Extract Induced Liver and Kidney Toxicities in ICR Mice[Pubmed: 32517000]
    Abstract This study investigated the leaves of Clinacanthus nutans for its bioactive compounds and acute and subacute toxicity effects of C. nutans ethanolic leaf extract (CELE) on blood, liver and kidneys of ICR mice. A total of 10 8-week-old female mice were divided into groups A (control) and B (2000 mg/kg) for the acute toxicity study. A single dose of 2000 mg/kg was administered to group B through oral gavage and mice were monitored for 14 days. In the subacute toxicity study, mice were divided into five groups: A (control), B (125 mg/kg), C (250 mg/kg), D (500 mg/kg) and E (1000 mg/kg). The extract was administered daily for 28 days via oral gavage. The mice were sacrificed, and samples were collected for analyses. Myricetin, orientin, isoorientin, vitexin, isovitexin, isookanin, apigenin and ferulic acid were identified in the extract. Twenty-eight days of continuous oral administration revealed significant increases (p < 0.05) in creatinine, ALT and moderate hepatic and renal necrosis in groups D and E. The study concluded that the lethal dose (LD50) of CELE in mice is greater than 2000 mg/kg and that repeated oral administrations of CELE for 28 days induced hepatic and renal toxicities at 1000 mg/kg in female ICR mice. Keywords: Clinacanthus nutans; ICR mice; acute toxicity; biochemical parameters; histopathology; isookanin; myricetin; orientin; subacute toxicity; vitexin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4686 mL 17.343 mL 34.6861 mL 69.3722 mL 86.7152 mL
    5 mM 0.6937 mL 3.4686 mL 6.9372 mL 13.8744 mL 17.343 mL
    10 mM 0.3469 mL 1.7343 mL 3.4686 mL 6.9372 mL 8.6715 mL
    50 mM 0.0694 mL 0.3469 mL 0.6937 mL 1.3874 mL 1.7343 mL
    100 mM 0.0347 mL 0.1734 mL 0.3469 mL 0.6937 mL 0.8672 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    橙皮素-7-甲醚; Hesperetin-7-methyl ether CFN90876 N/A C17H16O6 = 316.3 10mg QQ客服:3257982914
    圣草酚 7,3',4'-三甲醚; 7,3',4'-Tri-O-methyleriodictyol CFN89491 70987-96-1 C18H18O6 = 330.33 5mg QQ客服:2056216494
    (2S)-5,7,3'4'-四甲氧基二氢黄酮; (2S)-5,7,3',4'-tetramethoxyflavanone CFN95406 74628-43-6 C19H20O6 = 344.4 10mg QQ客服:1457312923
    5,6,7,3',4'-五甲氧基二氢黄酮; 5,6,7,3',4'-Pentamethoxyflavanone CFN95394 104193-93-3 C20H22O7 = 374.4 5mg QQ客服:1413575084
    异奥卡宁; Isookanin CFN90850 1036-49-3 C15H12O6 = 288.3 20mg QQ客服:1413575084
    黄诺马苷; Flavanomarein CFN91006 577-38-8 C21H22O11 = 450.4 5mg QQ客服:1413575084
    黄苏木素; Plathymenin CFN96496 492-12-6 C15H12O6 = 288.25 5mg QQ客服:1457312923
    圣草酚; Eriodictyol CFN99719 552-58-9 C15H12O6 = 288.25 20mg QQ客服:1457312923
    7-O-甲基圣草酚; 7-O-Methyleriodictyol CFN98833 51857-11-5 C16H14O6 = 302.3 5mg QQ客服:1457312923
    高圣草素; Homoeriodictyol CFN96489 446-71-9 C16H14O6 = 302.28 5mg QQ客服:2159513211

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