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  • 异地黄苷

    Isomartynoside

    异地黄苷
    产品编号 CFN97525
    CAS编号 94410-22-7
    分子式 = 分子量 C31H40O15 = 652.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The roots of Rehmannia glutinosa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异地黄苷 CFN97525 94410-22-7 1mg QQ客服:1413575084
    异地黄苷 CFN97525 94410-22-7 5mg QQ客服:1413575084
    异地黄苷 CFN97525 94410-22-7 10mg QQ客服:1413575084
    异地黄苷 CFN97525 94410-22-7 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • University of Toronto (Canada)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • University of Melbourne (Australia)
  • Medizinische Universit?t Wien (Austria)
  • Gyeongsang National University (Korea)
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  • Aveiro University (Portugal)
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  • Sant Gadge Baba Amravati University (India)
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  • University of Malaya (Malaysia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • Emirates Journal of Food and Agriculture.2022, 34(6): 528-536.
  • Food Funct.2022, 13(13):6923-6933.
  • Saudi Pharm J.2019, 27(1):145-153
  • Front Pharmacol.2022, 13:870553.
  • J Ethnopharmacol.2022, 289:115018.
  • Molecules.2020, 25(3):734
  • ACS Omega.2021, 6(36):23460-23474.
  • Industrial Crops and Products2022, 188:115638
  • J Bone Miner Res.2017, 32(12):2415-2430
  • Turkish Journal of Pharmaceutical Sciences2022, DOI: 10.4274
  • Journal of Functional Foods2022, 98:105271.
  • Evid Based Complement Alternat Med.2021, 2021:6687513.
  • Evid Based Complement Alternat Med.2020, 2020:8582318.
  • Int J Mol Sci.2017, 19(1)
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • Evid Based Complement Alternat Med.2016, 2016:4357656
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
  • Plant Growth Regulation2020, 90(2):383-392
  • Foods.2022, 11(12):1773.
  • Plant Sci.2021, 313:111069.
  • Drug Des Devel Ther.2020, 14:5189-5204.
  • Int J Anal Chem.2017, 2017:1254721
  • ...
  • 生物活性
    Description: Isomartynoside has inhibition against the angiotensin converting enzyme (ACE) activities, the IC 50 value is 505±26.7μg/ml, it may have antihypertensive effect. Isomartynoside also shows obvious anti-fatigue activity.
    In vitro:
    J. Ethnopharmacol., 2003, 89(1):151-4.
    Angiotensin converting enzyme inhibitory phenylpropanoid glycosides from Clerodendron trichotomum.[Pubmed: 14522447]
    The stems of Clerodendron trichotomum have been traditionally used for treatment of hypertension in far East Asia including China, Korea, and Japan.
    METHODS AND RESULTS:
    Bioassay-guided fractionation and purification of the EtOAc-soluble extract of Clerodendron trichotomum afforded acteoside (1), leucosceptoside A (2), martynoside (3), acteoside isomer (4), and Isomartynoside (5). The angiotensin converting enzyme (ACE) activities were significantly inhibited by the addition of these phenylpropanoid glycosides (1-5) in a dose-dependent manner of which IC(50) values were 373+/-9.3 microg/ml, 423+/-18.8 microg/ml, 524+/-28.1 microg/ml, 376+/-15.6 microg/ml, 505+/-26.7 microg/ml, respectively.
    CONCLUSIONS:
    These results suggest that the antihypertensive effect of Clerodendron trichotomum may be, at least in part, due to ACE inhibitory effect of phenylpropanoid glycosides.
    In vivo:
    Chinese Traditional & Herbal Drugs, 2014, 45(9):1223-7.
    Phenylpropanoids constituents of Pedicularis dichotoma.[Reference: WebLink]
    To study the phenylpropanoid constituents from the whole plants of Pedicularis dichotoma and the anti-fatigue activities in vivo.
    METHODS AND RESULTS:
    The n-BuOH fraction of 95% ethanol extract from P. dichotoma was separated and purified by silica gel, re-phase and Sephadex LH-20 column chromatography. The structures of the compounds were identified by physicochemical properties and various spectroscopic methods. The compounds were tested on anti-fatigue activity using mice in swimming model. Twelve phenylpropanoid compounds were isolated and purified. Their structures were identified as verbascoside (1), isoverbascoside (2), leucoseptoside A (3), jionoside D (4), martynoside (5), Isomartynoside (6), cis-martynoside (7), citrusin C (8), robustaside B (9), darendoside B (10), zizybeoside I (11), and salidroside (12). Verbascoside could obviously prolong the swimming time of mice.
    CONCLUSIONS:
    Compounds 1-12 are obtained from the plant for the first time, and compound 11 is reported from the plants of Pedicularis Linn. for the first time. Phenylpropanoids show obvious anti-fatigue activities.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5321 mL 7.6605 mL 15.321 mL 30.6419 mL 38.3024 mL
    5 mM 0.3064 mL 1.5321 mL 3.0642 mL 6.1284 mL 7.6605 mL
    10 mM 0.1532 mL 0.766 mL 1.5321 mL 3.0642 mL 3.8302 mL
    50 mM 0.0306 mL 0.1532 mL 0.3064 mL 0.6128 mL 0.766 mL
    100 mM 0.0153 mL 0.0766 mL 0.1532 mL 0.3064 mL 0.383 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    大车前苷; Plantamajoside CFN99522 104777-68-6 C29H36O16 = 640.6 20mg QQ客服:3257982914
    车前草苷D; Plantainoside D CFN93188 147331-98-4 C29H36O16 = 640.59 10mg QQ客服:1457312923
    贞桐苷A; Clerodenoside A CFN99691 164022-75-7 C35H44O17 = 736.7 5mg QQ客服:1413575084
    鞭打绣球苷A; Hemiphroside A CFN99697 165338-27-2 C31H40O16 = 668.7 5mg QQ客服:2056216494
    鞭打绣球苷B; Hemiphroside B CFN99698 165338-28-3 C31H38O17 = 682.6 5mg QQ客服:1457312923
    鞭打绣球苷B十乙酰酯; Hemiphroside B nonaacetate CFN89035 132302-25-1 C49H56O26 = 1060.98 5mg QQ客服:1457312923
    连翘酯苷A; Forsythoside A CFN99705 79916-77-1 C29H36O15 = 624.59 20mg QQ客服:2159513211
    连翘酯苷I; Forsythoside I CFN90988 1177581-50-8 C29H36O15 = 624.59 10mg QQ客服:215959384
    细叶远志苷 A; Tenuifoliside A CFN90770 139726-35-5 C31H38O17 = 682.6 20mg QQ客服:1457312923
    3,6-二芥子酰基蔗糖; 3,6'-Disinapoyl sucrose CFN90578 139891-98-8 C34H42O19 = 754.68 20mg QQ客服:215959384

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