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  • 异地芰普内酯

    Isololiolide

    异地芰普内酯
    产品编号 CFN95106
    CAS编号 38274-00-9
    分子式 = 分子量 C11H16O3 = 196.2
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Monoterpenoids
    植物来源 The leaves of Eucommia ulmoides Oliver
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    异地芰普内酯 CFN95106 38274-00-9 1mg QQ客服:2932563308
    异地芰普内酯 CFN95106 38274-00-9 5mg QQ客服:2932563308
    异地芰普内酯 CFN95106 38274-00-9 10mg QQ客服:2932563308
    异地芰普内酯 CFN95106 38274-00-9 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Nanjing University of Chinese Medicine (China)
  • Kyung Hee University (Korea)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • University of Vienna (Austria)
  • Center for protein Engineering (CIP) (Belgium)
  • Shanghai Institute of Organic Chemistry (China)
  • Lund University (Sweden)
  • Gyeongsang National University (Korea)
  • University of Stirling (United Kingdom)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Anna University (India)
  • University of Perugia (Italy)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytochem Anal.2016, 27(5):296-303
  • Pharmacognosy Magazine2017, 13(52):868-874
  • Plant Methods.2017, 13:108
  • Exp Parasitol.2017, 183:160-166
  • J Ethnopharmacol.2017, 198:87-90
  • Preprints2017, 2017120176
  • Phytochemistry Letters2017, 449-455
  • The Japan Society for Analytical Chemistry2017, 613-617
  • J Nat Med.2017, 71(2):380-388
  • Molecules.2018, 23(12):E3103
  • J Liq Chromatogr R T2018, 41(12):761-769
  • Food and Fermentation Industries2018, 44(371)
  • Nutrients.2019, 11(4):E936
  • Drug Invention Today2019, 12(6):1303-1306
  • Nutr Res Pract2019, 13:e45
  • Life Sci.2019, 216:259-270
  • Molecules.2019, 24(9):E1719
  • Environ Toxicol.2019, 34(4):513-520.
  • Phytomedicine.2019, 55:229-237
  • Appl. Sci.2020, 10,1304
  • Biomedicine & Pharmacotherapy2020, 125:109950
  • J Pharmaceut Biomed2020, 178:112894
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • ...
  • 生物活性
    Description: Isololiolide has phytotoxicity, it inhibited seedling growth of cress and barnyard grass. It also showed in vitro activity against both trypomastigote and intracellular amastigotes of Trypanosoma cruzi, with IC50 values of 32 µM and 40 µM, respectively. Isololiolide is an antioxidant response element (ARE) inducer, it has anti-inflammatory activity. It can exert a selective cytotoxic activity on hepatocarcinoma HepG2 cells as well as induce apoptosis through the modulation of apoptosis-related proteins.
    Targets: Antifection
    In vitro:
    Journal of Plant Biology, 2017, 60(1):75-81.
    Isolation and identification of two potential phytotoxic substances from the aquatic fern Marsilea crenata.[Reference: WebLink]
    Organic agriculture emphasized using of biologically originated herbicides and phytotoxic substances are being considered as a replacement to chemical herbicides. Marsilea crenata is an aquatic perennial fern distributed in the South-East Asian countries and is well known for various biological properties. However, to date, there has been no report that addresses the phytotoxicity of Marsilea crenata.
    METHODS AND RESULTS:
    Therefore, we explored phytotoxic properties and phytotoxic substances from Marsilea crenata. An aqueous methanol extracts of Marsilea crenata showed inhibition on the seedling growth of cress, lettuce, alfalfa, barnyard grass, Italian ryegrass, and foxtail fescue. Inhibition increased with increasing extract concentration. The extract was purified by several chromatographic steps and two phytotoxic substances were isolated and identified by spectroscopic analysis as loliolide and isololiolide. At the concentration of 30 μM, loliolide and isololiolide inhibited seedling growth of cress and barnyard grass by 41.3 to 51.1%, and 58.15 to 87.5% of control seedlings, respectively. The concentrations required for 50% inhibition of cress and barnyard grass seedlings ranged from 32.1 to 128.5 μM for loliolide, 37.0 to 176.2 μM for isololiolide.
    CONCLUSIONS:
    These results suggest these compounds may be responsible for phytotoxic effects of Marsilea crenata extract and could be an important part of organic agriculture.
    Bioorg Chem. 2019 Aug;89:103002.
    Antitrypanosomal activity of isololiolide isolated from the marine hydroid Macrorhynchia philippina (Cnidaria, Hydrozoa).[Pubmed: 31136901 ]
    Marine invertebrates are a rich source of small antiparasitic compounds. Among them, Macrorhynchia philippina is a chemically underexplored marine cnidarian.
    METHODS AND RESULTS:
    In the search for candidates against the neglected protozoan Chagas disease, we performed a bio-guided fractionation to obtain active compounds. The structural characterization of the active compound was determined using NMR analysis and MS and resulted in the isololiolide, a compound described for the first time in this species. It showed in vitro activity against both trypomastigote and intracellular amastigotes of Trypanosoma cruzi, with IC50 values of 32 µM and 40 µM, respectively, with no mammalian cytotoxicity (>200 µM). The lethal action was investigated in T. cruzi using different fluorophores to study: (i) mitochondrial membrane potential; (ii) plasma membrane potential and (iii) plasma membrane permeability.
    CONCLUSIONS:
    Our results demonstrated that isololiolide caused disruption of the plasma membrane integrity and a strong depolarization of the mitochondrial membrane potential, rapidly leading the parasite to death. Despite being considered a possible covalent inhibitor, safety in silico studies of isololiolide also considered neither mutagenic nor genotoxic potential. Additionally, isololiolide showed no resemblance to interference compounds (PAINS), and it succeeded in most filters for drug-likeness. Isololiolide is a promising candidate for future optimization against Chagas disease.
    Cancer Prev Res (Phila). 2013 Sep;6(9):989-99.
    Cultivated sea lettuce is a multiorgan protector from oxidative and inflammatory stress by enhancing the endogenous antioxidant defense system.[Pubmed: 24005795]
    The health-promoting effects of seaweeds have been linked to antioxidant activity that may counteract cancer-causing oxidative stress-induced damage and inflammation.
    METHODS AND RESULTS:
    Although antioxidant activity is commonly associated with direct radical scavenging activity, an alternative way to increase the antioxidant status of a cell is to enhance the endogenous (phase II) defense system consisting of cytoprotective antioxidant enzymes, including NAD(P)H:quinone oxidoreductase 1 (NQO1). These enzymes are transcriptionally regulated by the antioxidant response element (ARE) via the transcription factor Nrf2. Extracts derived from cultivated Ulva sp., a green alga regarded as a marine vegetable (sea lettuce), potently activated the Nrf2-ARE pathway in IMR-32 neuroblastoma and LNCaP prostate cancer cells. RNA interference studies showed that Nrf2 and phosphoinositide 3-kinase (PI3K) are essential for the phase II response in IMR-32 cells. Activity-enriched fractions induced Nrf2 nuclear translocation and target gene transcription, and boosted the cellular glutathione level and therefore antioxidant status. A single-dose gavage feeding of Ulva-derived fractions increased Nqo1 transcript levels in various organs. Nqo1 induction spiked in different tissues, depending on the specific chemical composition of each administered fraction.
    CONCLUSIONS:
    We purified and characterized four ARE inducers in this extract, including loliolide (1), isololiolide (2), a megastigmen (3), and a novel chlorinated unsaturated aldehyde (4). The ARE-active fractions attenuated lipopolysaccharide-induced iNOS and Cox2 gene expression in macrophagic RAW264.7 cells, decreasing nitric oxide (NO) and prostaglandin E2 (PGE2) production, respectively. Nqo1 activity and NO production were abrogated in nrf2(-/-) mouse embryonic fibroblasts, providing a direct link between the induction of phase II response and anti-inflammatory activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.0968 mL 25.4842 mL 50.9684 mL 101.9368 mL 127.421 mL
    5 mM 1.0194 mL 5.0968 mL 10.1937 mL 20.3874 mL 25.4842 mL
    10 mM 0.5097 mL 2.5484 mL 5.0968 mL 10.1937 mL 12.7421 mL
    50 mM 0.1019 mL 0.5097 mL 1.0194 mL 2.0387 mL 2.5484 mL
    100 mM 0.051 mL 0.2548 mL 0.5097 mL 1.0194 mL 1.2742 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    地芰普内酯; Loliolid CFN92750 5989-02-6 C11H16O3 = 196.2 5mg QQ客服:2159513211
    异地芰普内酯; Isololiolide CFN95106 38274-00-9 C11H16O3 = 196.2 5mg QQ客服:1413575084
    4-羟基-2,6,6-三甲基-1-环己烯羧酸; 4-Hydroxy-2,6,6-trimethyl-1-cyclohexenecarboxylic acid CFN97070 62218-55-7 C10H16O3 = 184.2 5mg QQ客服:2159513211
    地黄苦苷; Rehmapicroside CFN90760 104056-82-8 C16H26O8 = 346.4 5mg QQ客服:1413575084
    苦番红花素; Picrocrocin CFN91177 138-55-6 C16H26O7 = 330.4 5mg QQ客服:2932563308
    β-蒎烯; Beta-pinene CFN93287 18172-67-3 C10H16 = 136.2 20mg QQ客服:2932563308
    α-蒎烯; Alpha-pinene CFN93285 80-56-8 C10H16 = 136.2 20mg QQ客服:215959384

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