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  • 异去氢钩藤碱

    Isocorynoxeine

    异去氢钩藤碱
    产品编号 CFN98155
    CAS编号 51014-29-0
    分子式 = 分子量 C22H26N2O4 = 382.45
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Uncaria rhynchophylla.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异去氢钩藤碱 CFN98155 51014-29-0 10mg QQ客服:2159513211
    异去氢钩藤碱 CFN98155 51014-29-0 20mg QQ客服:2159513211
    异去氢钩藤碱 CFN98155 51014-29-0 50mg QQ客服:2159513211
    异去氢钩藤碱 CFN98155 51014-29-0 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universitas Airlangga (Indonesia)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Georgia Institute of Technology (USA)
  • University of South Australia (Australia)
  • Worcester Polytechnic Institute (USA)
  • University of Wuerzburg (Germany)
  • Universiti Malaysia Pahang (Malaysia)
  • Auburn University (USA)
  • Universidade da Beira Interior (Germany)
  • Chinese University of Hong Kong (China)
  • University of Wisconsin-Madison (USA)
  • Kitasato University (Japan)
  • Sapienza University of Rome (Italy)
  • University of Eastern Finland (Finland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • QASCF2022, 14(4).
  • J. Korean Wood Sci. Technol.2022, 50(5):338-352.
  • Arch Biochem Biophys.2020, 687:108384.
  • J Hematol Oncol.2018, 11(1):112
  • Planta Med.2019, 85(9-10):766-773
  • Biomolecules.2020, 10(2):E184
  • Food and Fermentation Industries2018, 44(371)
  • Phytomedicine.2019, 57:95-104
  • Plants (Basel).2023, 12(22):3877.
  • Biol Pharm Bull.2017, 40(6):797-806
  • Phytomedicine.2018, 38:12-23
  • Toxins (Basel).2019, 11(10):E575
  • Int J Mol Sci.2021, 22(17):9400.
  • Front Pharmacol.2018, 9:236
  • Molecules2022, 27(9):2613.
  • Biomolecules.2019, 9(11):E696
  • Chem Biol Interact.2018, 283:59-74
  • Scientific World Journal.2014, 2014:654193
  • J Liq Chromatogr R T2018, 41(12):761-769
  • Front Pharmacol.2023, 14:1095083.
  • Molecules.2017, 22(3)
  • Foods.2021, 10(12):2929.
  • Phytomedicine.2019, 56:48-56
  • ...
  • 生物活性
    Description: Isocorynoxeine, an isorhynchophylline-related alkaloid, exhibits a dose-dependent inhibition of 5-HT2A receptor-mediated current response with an IC50 of 72.4 μM. Isocorynoxeine shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage, it exhibits a significant neuroprotective effect against glutamate-induced HT22 cell death at the maximum concentration.
    Targets: 5-HT2A receptor | NO
    In vivo:
    Planta Med. 2015 Jan;81(1):46-55.
    Isolation and identification of twelve metabolites of isocorynoxeine in rat urine and their neuroprotective activities in HT22 cell assay.[Pubmed: 25519834]
    Isocorynoxeine, one of the major alkaloids from Uncaria Hook, shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage.
    METHODS AND RESULTS:
    In this paper, the metabolism of Isocorynoxeine was investigated in rats. Twelve metabolites and the parent drug were isolated by using solvent extraction and repeated chromatographic methods, and determined by spectroscopic methods including UV, MS, NMR, and CD experiments. Seven new compounds were identified as 11-hydroxyIsocorynoxeine, 5-oxoisocorynoxeinic acid-22-O-β-D-glucuronide, 10-hydroxyIsocorynoxeine, 17-O-demethyl-16,17-dihydro-5-oxoIsocorynoxeine, 5-oxoisocorynoxeinic acid, 21-hydroxy-5-oxoIsocorynoxeine, and oxireno[18, 19]-5-oxoIsocorynoxeine, together with six known compounds identified as Isocorynoxeine, 18,19-dehydrocorynoxinic acid, 18,19-dehydrocorynoxinic acid B, corynoxeine, Isocorynoxeine-N-oxide, and corynoxeine-N-oxide. Possible metabolic pathways of Isocorynoxeine are proposed. Furthermore, the activity assay for the parent drug and some of its metabolites showed that Isocorynoxeine exhibited a significant neuroprotective effect against glutamate-induced HT22 cell death at the maximum concentration. However, little or weak neuroprotective activities were observed for M-3, M-6, M-7, and M-10.
    CONCLUSIONS:
    Our present study is important to further understand their metabolic fate and disposition in humans.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6147 mL 13.0736 mL 26.1472 mL 52.2944 mL 65.368 mL
    5 mM 0.5229 mL 2.6147 mL 5.2294 mL 10.4589 mL 13.0736 mL
    10 mM 0.2615 mL 1.3074 mL 2.6147 mL 5.2294 mL 6.5368 mL
    50 mM 0.0523 mL 0.2615 mL 0.5229 mL 1.0459 mL 1.3074 mL
    100 mM 0.0261 mL 0.1307 mL 0.2615 mL 0.5229 mL 0.6537 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异钩藤碱酸; Isorhynchophyllic acid CFN98132 144525-05-3 C21H26N2O4 = 370.44 5mg QQ客服:2159513211
    柯诺辛, 钩藤碱; Corynoxine CFN90218 6877-32-3 C22H28N2O4 = 384.47 20mg QQ客服:2159513211
    异钩藤碱; Isorhyncophylline CFN92553 6859-01-4 C22H28N2O4 = 384.5 20mg QQ客服:2159513211
    钩藤碱; Rhynchophylline CFN98131 76-66-4 C22H28N2O4 = 384.47 20mg QQ客服:1457312923
    去氢钩藤碱; Corynoxeine CFN98154 630-94-4 C22H26N2O4 = 382.45 20mg QQ客服:2056216494
    异去氢钩藤碱; Isocorynoxeine CFN98155 51014-29-0 C22H26N2O4 = 382.45 20mg QQ客服:1457312923
    二氢柯楠因; Dihydrocorynantheine CFN92844 4684-43-9 C22H28N2O3 = 368.5 5mg QQ客服:1457312923

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