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  • Isoatriplicolide tiglate

    Isoatriplicolide tiglate

    Isoatriplicolide tiglate
    产品编号 CFN92955
    CAS编号 133559-39-4
    分子式 = 分子量 C20H22O6 = 358.39
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The fruits of Paulownia tomentosa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Isoatriplicolide tiglate CFN92955 133559-39-4 1mg QQ客服:215959384
    Isoatriplicolide tiglate CFN92955 133559-39-4 5mg QQ客服:215959384
    Isoatriplicolide tiglate CFN92955 133559-39-4 10mg QQ客服:215959384
    Isoatriplicolide tiglate CFN92955 133559-39-4 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Chinese Materia Medica (China)
  • Georgia Institute of Technology (USA)
  • Chinese University of Hong Kong (China)
  • Nanjing University of Chinese Medicine (China)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • University of Limpopo (South Africa)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • University of Queensland (Australia)
  • The Australian National University (Australia)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • China Medical University (Taiwan)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Universidad Miguel Hernández (Spain)
  • Complutense University of Madrid (Spain)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Synthetic and Systems Biotechnology2023, j.synbio.
  • Int. J. Mol. Sci.2023, 24(20),15294.
  • J Chromatogr A.2017, 1518:46-58
  • J Food Sci.2022, 87(11):4905-4916.
  • Neurochem Res.2021, s11064-021-03449-0
  • J Biomol Struct Dyn.2022, 1-21.
  • FEBS Lett.2015, 589(1):182-7
  • Front Pharmacol.2022, 13:972825.
  • Analytical methods2019, 11(6)
  • J of Dentistry & Oral Health2019, 2641-1962
  • Journal of Plant Growth Regulation2022, 10705-2.
  • Natural Product Communications2021, 16(9):1-10.
  • Front Pharmacol.2020, 11:683.
  • Mol Med Rep.2014, 9(5):1653-9
  • Molecules 2022, 27(3),960.
  • Oncology Letters2018, 4690-4696
  • Food Chem. 2020, 320:126530
  • Antioxidants (Basel).2021, 10(9):1487.
  • Front Pharmacol.2021, 12:761922.
  • Anal Bioanal Chem.2020, 412(12):3005-3015.
  • Heliyon.2023, 9(12):e22932.
  • Front Plant Sci.2023, 14:1207940.
  • Biomed Pharmacother.2019, 111:262-269
  • ...
  • 生物活性
    Description: Isoatriplicolide tiglate acts as an antiproliferation agents particularly against breast and cervical cancers by inducing cell cycle arrest in the S/G2 phase and caspase dependent apoptosis at relatively low (< 10 μg/mL) and high (> 50 μg/mL) concentrations, respectively. Isoatriplicolide tiglate exhibits significant neuroprotective activity against glutamate-induced toxicity at concentrations ranging from 1 uM to 10 uM.
    Targets: Caspase
    In vitro:
    Molecules. 2012 May 18;17(5):5945-51.
    Inhibitory effect and mechanism on antiproliferation of isoatriplicolide tiglate (PCAC) from Paulownia Coreana.[Pubmed: 22609785]
    Paulownia coreana has traditionally been used as the medicine and health food in the treatment of cancer and infectious diseases. In the present study, a new antiproliferation agent, Isoatriplicolide tiglate (PCAC) was isolated from the chloroform soluble fraction of the leaves of Paulownia coreana.
    METHODS AND RESULTS:
    The antiproliferation activities of PCAC plant extract was examined in breast and cervical cancer cell lines in a time-and dose-dependent manners. Our in vitro experiments showed that PCAC suppresses the cell growth and proliferation of cancer cells at a relatively low concentration (< 10 μg/mL) and induces apoptosis at a high concentration (> 50 μg/mL). Western blot analysis showed that concentration higher than 50 μg/mL induces a time-dependent increase in the percentage of apoptotic cells. In this case, PCAC uses both extrinsic and intrinsic pathways for the apoptosis. PCAC treatment decreased the expression of pro-caspase 8, 9, and 3, the main regulators of apoptotic cell death, in MDA-MB-231 cells, accompanied by the activation of caspase 8, 9, and 3. More importantly, PCAC inhibited the in vitro proliferation of six other human breast and cervical cancer cell lines.
    CONCLUSIONS:
    In conclusion, our data strongly suggest that PCAC acts as an antiproliferation agents particularly against breast and cervical cancers by inducing cell cycle arrest in the S/G2 phase and caspase dependent apoptosis at relatively low (< 10 μg/mL) and high (> 50 μg/mL) concentrations, respectively.
    Phytother Res. 2010 Dec;24(12):1898-900.
    Neuroprotective effects of a sesquiterpene lactone and flavanones from Paulownia tomentosa Steud. against glutamate-induced neurotoxicity in primary cultured rat cortical cells.[Pubmed: 20683844 ]
    The neuroprotective effects of Paulownia tomentosa against glutamate-induced neurotoxicity were studied in primary cultured rat cortical cells. It was found that the aqueous extract of this medicinal plant significantly attenuated glutamate-induced toxicity. In order to clarify the mechanism(s) underlying this neuroprotective effect, the active fractions and components were isolated and identified.
    METHODS AND RESULTS:
    Five compounds were isolated as the methanol extracts from air-dried flowers of P. tomentosa. Isoatriplicolide tiglate exhibited significant neuroprotective activity against glutamate-induced toxicity at concentrations ranging from 1 μM to 10 μM, and exhibited cell viability of approximately 43-78%.
    CONCLUSIONS:
    Therefore, the neuroprotective effect of P. tomentosa might be due to the inhibition of glutamate-induced toxicity by the sesquiterpene lactone derivative it contains.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7903 mL 13.9513 mL 27.9026 mL 55.8051 mL 69.7564 mL
    5 mM 0.5581 mL 2.7903 mL 5.5805 mL 11.161 mL 13.9513 mL
    10 mM 0.279 mL 1.3951 mL 2.7903 mL 5.5805 mL 6.9756 mL
    50 mM 0.0558 mL 0.279 mL 0.5581 mL 1.1161 mL 1.3951 mL
    100 mM 0.0279 mL 0.1395 mL 0.279 mL 0.5581 mL 0.6976 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Carabrolactone A; Carabrolactone A CFN99286 1187925-30-9 C15H22O5 = 282.3 5mg QQ客服:1457312923
    11(13)-去氢腋生依瓦菊素; 11(13)-Dehydroivaxillin CFN97438 87441-73-4 C15H20O4 = 264.3 5mg QQ客服:215959384
    Aeruginolactone; Aeruginolactone CFN92791 1005208-88-7 C15H20O3 = 248.3 5mg QQ客服:1413575084
    野马追内酯O; Eupalinolide O CFN91839 2170228-67-6 C22H26O8 = 418.4 5mg QQ客服:3257982914
    野马追内酯A; Eupalinolide A CFN90381 877822-41-8 C24H30O9 = 462.49 20mg QQ客服:1413575084
    野马追内酯B; Eupalinolide B CFN90382 877822-40-7 C24H30O9 = 462.49 20mg QQ客服:2056216494
    野马追内酯K; Eupalinolide K CFN99435 108657-10-9 C20H26O6 = 362.4 10mg QQ客服:2159513211
    4,15-Isoatriplicolide methylacrylate; 4,15-Isoatriplicolide methylacrylate CFN92956 133559-38-3 C19H20O6 = 344.36 5mg QQ客服:1413575084
    Isoatriplicolide tiglate; Isoatriplicolide tiglate CFN92955 133559-39-4 C20H22O6 = 358.39 5mg QQ客服:2056216494

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