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  • 异落新妇苷

    Isoastilbin

    异落新妇苷
    产品编号 CFN98905
    CAS编号 54081-48-0
    分子式 = 分子量 C21H22O11 = 450.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The rhizomes of Simlax glabra Roxb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异落新妇苷 CFN98905 54081-48-0 1mg QQ客服:2056216494
    异落新妇苷 CFN98905 54081-48-0 5mg QQ客服:2056216494
    异落新妇苷 CFN98905 54081-48-0 10mg QQ客服:2056216494
    异落新妇苷 CFN98905 54081-48-0 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Chinese Materia Medica (China)
  • Gyeongsang National University (Korea)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Universidade da Beira Interior (Germany)
  • University of Toulouse (France)
  • Lodz University of Technology (Poland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biochemical Systematics and Ecology2018, 81
  • J Int Med Res.2021, 49(7):3000605211032849.
  • Molecules.2017, 22(3)
  • Industrial Crops and Products2022, 188:115596.
  • Phytomedicine.2021, 84:153501.
  • Tokyo Pharmaceutical University2020, 500001431953.
  • Drug Chem Toxicol.2020, 1-14.
  • Mol Immunol. 2016, 78:121-132
  • Food Funct.2022, doi: 10.1039
  • J-STAGE2015, 249-255
  • bioRxiv - Molecular Biology2023, 535548.
  • J Food Compos Anal2017, 62:197-204
  • J Asian Nat Prod Res.2019, 5:1-17
  • HortTechnology2016, 26(6):816-819
  • Toxicol Appl Pharmacol.2021, 427:115668.
  • Natural Product Communications2022, 7(3):1-7.
  • Food Science and Biotechnology2015, 2205-2212
  • Adaptive Medicine 2020, 12(1): 4-10
  • Molecules.2016, 21(10)
  • Korean Herb. Med. Inf.2020, 8(2):205-213
  • Korea Institute of Oriental Medicine2020, doi: 10.21203.
  • Food and Fermentation Industries2019, 45(7):45-51
  • Food Chem.2018, 262:78-85
  • ...
  • 生物活性
    Description: Isoastilbin has anti-acne and tyrosinase inhibition properties.Isoastilbin, neoastilbin, astilbin and taxifolin have antimicrobial activities, they depress the growth of Streptococcus sobrinus (S. sobrinus) over a concentration range of 9.32-42.7 ug/ml and show GTase inhibitory activity with IC50 values in the range 27.4-57.3 ug/ml.
    Targets: Antifection | Tyrosinase | GTase
    In vitro:
    J. Wood Sci., 2009, 55(4):308-13.
    Antimicrobial activity against Streptococcus sobrinus and glucosyltransferase inhibitory activity of taxifolin and some flavanonol rhamnosides from kempas (Koompassia malaccensis) extracts[Reference: WebLink]
    Twenty plant materials collected from the islands of Java and Kalimantan in Indonesia were extracted with 50% aqueous ethanol (crude extract).
    METHODS AND RESULTS:
    The crude extracts were assayed for antimicrobial activities against Streptococcus sobrinus and for glucosyltransferase (GTase) inhibition. Fourteen extracts inhibited the growth of S. sobrinus by more than 50% and six extracts inhibited GTase activity by more than 50% at a concentration of 100 μg/ml. Koompassia malaccensis (kempas) extracts showed 90% depression of S. sobrinus growth and 80% inhibition of GTase activity at a concentration of 100 μg/ml. Kempas crude extracts were subjected to column chromatography using Sephadex LH-20 and then preparative high-performance liquid chromatography to isolate four compounds A, B, C, and D. These compounds were identified as taxifolin and the flavanonol rhamnoside isomers neoastilbin, astilbin, and Isoastilbin, respectively, from 1H and 13C nuclear magnetic resonance (NMR) spectra and other two-dimensional NMR techniques (COSY, HMBC, and HMQC). Each compound depressed the growth of S. sobrinus over a concentration range of 9.3242.7 μg/ml and showed GTase inhibitory activity with IC₅₀ values in the range 27.4-57.3 μg/ml.
    CONCLUSIONS:
    Taxifolin and flavanonol rhamnoside isomers isolated for the first time from kempas could be potent compounds for preventing dental caries.
    Wood Research Journal ,2010, 1(1):45-9.
    Anti-acne and Tyrosinase Inhibition Properties of Taxifolin and Some Flavanonol Rhamnosides from Kempas ( Koompassia malaccensis )[Reference: WebLink]
    Taxifolin (1) and some flavanonol rhamnosides (neoastilbin (2), astilbin (3), and Isoastilbin (4)) have been isolated from kempas (Koompassia malaccensis). Our previous research about antimicrobial activity against Streptococcus sobrinus and glucosyltransferase inhibitory activity of these compounds have been reported.
    METHODS AND RESULTS:
    Now, we carried out the antiacne and tyrosinase inhibition properties of all four compounds. Antimicrobial against Propionibacterium acnes, P. acnes lipase inhibitory activity and antioxidant activity were established for anti-acne activity. Tyrosinase inhibition property was measured using L-tyrosine and L-DOPA as substrate. The results for anti-acne showed that no antimicrobial activity against P. acnes for all compounds, the best lipase inhibition properties showed on compound 4 with IC50 about 1.36 g/ml, and % inhibition for antioxidant at concentration 10 g/ml are 31.16, 25.64, 28.47, and 31.01% respectively. Tyrosinase inhibition of compound 1 at concentration 1 mg/ml is 24.12% for monophenolase and 5.18% for diphenolase. Compound 2 has tyrosinase inhibition about 25.95% (monophenolase) and 14.18% (diphenolase) at concentration 1 mg/ml. Compound 3 has tyrosinase inhibition about 27.17% (monophenolase) and 6.23% (diphenolase) at same concentration, while compound 4 has tyrosinase inhibition about 11.17% (monophenolase) and 9.75% (diphenolase).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2202 mL 11.1012 mL 22.2025 mL 44.405 mL 55.5062 mL
    5 mM 0.444 mL 2.2202 mL 4.4405 mL 8.881 mL 11.1012 mL
    10 mM 0.222 mL 1.1101 mL 2.2202 mL 4.4405 mL 5.5506 mL
    50 mM 0.0444 mL 0.222 mL 0.444 mL 0.8881 mL 1.1101 mL
    100 mM 0.0222 mL 0.111 mL 0.222 mL 0.444 mL 0.5551 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    落新妇苷; Astilbin CFN98371 29838-67-3 C21H22O11 = 450.4 20mg QQ客服:1413575084
    异落新妇苷; Isoastilbin CFN98905 54081-48-0 C21H22O11 = 450.4 10mg QQ客服:215959384
    新落新妇苷; Neoastilbin CFN91093 54081-47-9 C21H22O11 = 450.40 20mg QQ客服:2056216494
    (2S,3S)-(-)-蚊母树苷; (2S,3S)-(-)-Glucodistylin CFN99389 129212-92-6 C21H22O12 = 466.4 5mg QQ客服:3257982914
    花旗松素 3'-O-葡萄糖苷; Taxifolin 3'-O-glucoside CFN96494 31106-05-5 C21H22O12 = 342.29 5mg QQ客服:2159513211
    Taxifolin 7-O-rhamnoside; Taxifolin 7-O-rhamnoside CFN96539 137592-12-2 C21H22O11 = 450.40 20mg QQ客服:2159513211
    花旗松素-7-O-葡萄糖苷; Taxifolin 7-O-glucoside CFN91506 14292-40-1 C21H22O12 = 466.4 10mg QQ客服:215959384
    7-Neohesperidosides; 7-Neohesperidosides CFN95018 28383-41-7 C28H34O16 = 626.6 5mg QQ客服:2159513211
    异黄杞苷; Isoengeletin CFN95284 30987-58-7 C21H22O10 = 434.4 5mg QQ客服:2159513211
    二氢山奈酚-7-O-鼠李糖苷; Aromadendrin 7-O-rhamnoside CFN89542 69135-41-7 C21H22O10 = 434.39 5mg QQ客服:3257982914

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