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  • 异土木香内酯

    Isoalantolactone

    异土木香内酯
    产品编号 CFN98107
    CAS编号 470-17-7
    分子式 = 分子量 C16H20O2 = 232.32
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Sesquiterpenoids
    植物来源 The roots of Inula helenium L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    异土木香内酯 CFN98107 470-17-7 10mg QQ客服:2159513211
    异土木香内酯 CFN98107 470-17-7 20mg QQ客服:2159513211
    异土木香内酯 CFN98107 470-17-7 50mg QQ客服:2159513211
    异土木香内酯 CFN98107 470-17-7 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Toronto (Canada)
  • Mahatma Gandhi University (India)
  • Universidad de Antioquia (Colombia)
  • Seoul National University of Science and Technology (Korea)
  • University of Auckland (New Zealand)
  • University of Otago (New Zealand)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • University of Perugia (Italy)
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  • Wroclaw Medical University (Poland)
  • Periyar University (India)
  • University of Sao Paulo (Brazil)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Indian Institute of Science (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Microchemical Journal2024: 196:109676.
  • LWT2021, 147:111620.
  • Cell Mol Biol(Noisy-le-grand)2019, 65(7):77-83
  • Pharmaceutics.2022, 14(12):2765.
  • Neuropharmacology2019, 151437
  • 2023, 24(6):5769.Int J Mol Sci.
  • Molecules.2019, 24(4):E744
  • Front Chem.2022, 10:1048467.
  • Org Biomol Chem.2017, 15(31):6483-6492
  • Biol Pharm Bull.2018, 41(1):65-72
  • J AOAC Int.2023, 106(1):56-64.
  • Food Funct.2022, 13(23):12105-12120.
  • Med Sci Monit.2019, 25:9499-9508
  • Natural Product Res.&Deve.2022, 1001-6880.
  • Plant J.2021, 107(6):1711-1723.
  • Nutr Metab (Lond).2019, 16:31
  • Toxicological Research2020, doi: 10.1007.
  • Int J Mol Sci.2018, 19(9):E2601
  • J Hepatocell Carcinoma.2022, 9:327-341.
  • Mol Pharm.2018, 15(8):3285-3296
  • Nutrients2020, 12(2):488
  • Evid-Based Compl Alt2020, 7202519:13
  • Analytical sci. & Tech2016, 186-193
  • ...
  • 生物活性
    Description: Isoalantolactone, an apoptosis inducer, possesses multiple biological activities including antifungal, anthelmintic, antimicrobial, anti-inflammatory, antitrypanosomal activities and antiproliferative effects on several cancer cell lines, such as colon, melanoma, ovary, prostate, lung, and leukemia. Isoalantolactone induces apoptosis, may be mediated through caspase-dependent apoptotic pathways, S phase arrest, inhibition of phosphorylation of PI3K/Akt, and downregulation of Bcr/Abl.
    Targets: Bcr-Abl | PI3K | Akt | PARP | Caspase | ROS | MMP(e.g.TIMP) | NF-kB | p65 | Bcl-2/Bax | p38MAPK
    In vitro:
    Phytother Res. 2014 Nov;28(11):1679-86.
    Growth inhibition effects of isoalantolactone on K562/A02 cells: caspase-dependent apoptotic pathways, S phase arrest, and downregulation of Bcr/Abl.[Pubmed: 24865355]
    Isoalantolactone, a sesquiterpene lactone, is the active component of Inula helenium (Compositae). It has been reported that isoalantolactone has the capacity to inhibit tumor cell growth through induction of apoptosis. The purposes of this study were to evaluate the effects of isoalantolactone on the human erythroleukemia drug-resistant cell line K562/A02 and to provide evidence of its function as a potent therapeutic agent in patients with chronic myelogenous leukemia with the Bcr/Abl phenotype.
    METHODS AND RESULTS:
    Our results showed that isoalantolactone significantly inhibited K562/A02 cell growth by downregulating Bcr/Abl expression. Isoalantolactone also induced apoptosis via increase generation of reactive oxygen species, modulation of the protein levels of Bcl-2 family members, caspase activation, poly ADP-ribose polymerase (PARP) cleavage, and release of cytochrome c. We also observed that isoalantolactone inhibited proliferation by inducing cell cycle arrest in the S phase.
    CONCLUSIONS:
    Taken together, all these findings support that growth inhibition effects of isoalantolactone on K562/A02 cells may be mediated through caspase-dependent apoptotic pathways, S phase arrest, and downregulation of Bcr/Abl.
    Crop Prot., 2006, 25(5):508-11.
    Repellent, insecticidal and phytotoxic activities of isoalantolactone from Inula racemosa.[Reference: WebLink]
    Isoalantolactone, a natural product isolated from traditional Chinese medicinal herb roots of Inula racemosa Hook. f. (Fam. Compositae), has been shown to possess strong antifungal activities.
    METHODS AND RESULTS:
    The present investigation showed that isoalantolactone also exhibited repellent and toxic activities against rice weevil [Sitophilus oryzae (L.) (Coleoptera: Curculionidae)] based on a food preference apparatus and a poisoned food technique. The toxicity of isoalantolactone to rice weevil was dose dependent, whereas the repellency was not. Isoalantolactone showed strong phytotoxic effects on seed germination and seedling growth of wheat at a concentration of 500 μg ml−1 for 60 h; however, this side effect could be reduced markedly by shortening the treating time at this concentration.
    CONCLUSIONS:
    Results indicate that isoalantolactone might be considered for wheat seeds preservation in control of storage weevils.
    In vivo:
    Int J Biol Sci. 2012;8(4):533-47.
    Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells.[Pubmed: 22532787 ]
    Isoalantolactone, a sesquiterpene lactone compound possesses antifungal, antibacteria, antihelminthic and antiproliferative activities.
    METHODS AND RESULTS:
    In the present study, we found that Isoalantolactone inhibits growth and induces apoptosis in pancreatic cancer cells. Further mechanistic studies revealed that induction of apoptosis is associated with increased generation of reactive oxygen species, cardiolipin oxidation, reduced mitochondrial membrane potential, release of cytochrome c and cell cycle arrest at S phase. N-Acetyl Cysteine (NAC), a specific ROS inhibitor restored cell viability and completely blocked Isoalantolactone-mediated apoptosis in PANC-1 cells indicating that ROS are involved in Isoalantolactone-mediated apoptosis. Western blot study showed that Isoalantolactone increased the expression of phosphorylated p38 MAPK, Bax, and cleaved caspase-3 and decreased the expression of Bcl-2 in a dose-dependent manner. No change in expression of phosphorylated p38 MAPK and Bax was found when cells were treated with Isoalantolactone in the presence of NAC, indicating that activation of these proteins is directly dependent on ROS generation.
    CONCLUSIONS:
    The present study provides evidence for the first time that Isoalantolactone induces ROS-dependent apoptosis through intrinsic pathway. Furthermore, our in vivo toxicity study demonstrated that Isoalantolactone did not induce any acute or chronic toxicity in liver and kidneys of CD1 mice at dose of 100 mg/kg body weight. Therefore, Isoalantolactone may be a safe chemotherapeutic candidate for the treatment of human pancreatic carcinoma.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.3044 mL 21.522 mL 43.0441 mL 86.0882 mL 107.6102 mL
    5 mM 0.8609 mL 4.3044 mL 8.6088 mL 17.2176 mL 21.522 mL
    10 mM 0.4304 mL 2.1522 mL 4.3044 mL 8.6088 mL 10.761 mL
    50 mM 0.0861 mL 0.4304 mL 0.8609 mL 1.7218 mL 2.1522 mL
    100 mM 0.043 mL 0.2152 mL 0.4304 mL 0.8609 mL 1.0761 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    别土木香内酯; Alloalantolactone CFN91880 64340-41-6 C15H20O2 = 232.32 10mg QQ客服:2056216494
    狭叶依瓦菊素; Ivangustin CFN92599 14164-59-1 C15H20O3 = 248.3 10mg QQ客服:1457312923
    土木香内酯; Alantolactone CFN99934 546-43-0 C15H20O2 = 232.32 20mg QQ客服:2159513211
    1beta-羟基土木香内酯; 1beta-Hydroxyalantolactone CFN92600 68776-47-6 C15H20O3 = 248.3 10mg QQ客服:3257982914
    异土木香内酯; Isoalantolactone CFN98107 470-17-7 C16H20O2 = 232.32 20mg QQ客服:3257982914
    11,13-二氢依瓦菊林; 11,13-Dihydroivalin CFN97819 150150-61-1 C15H22O3 = 250.34 5mg QQ客服:2159513211

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