冬青素A

Ilexgenin A

	产品编号	CFN93149
	CAS编号	108524-94-3
	分子式 = 分子量	C₃₀H₄₆O₆ = 502.69
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The roots of Ilex pubescens Hook.et Arn.
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产品名称	产品编号	CAS编号	包装	QQ客服
冬青素A	CFN93149	108524-94-3	10mg	QQ客服：1457312923
冬青素A	CFN93149	108524-94-3	20mg	QQ客服：1457312923
冬青素A	CFN93149	108524-94-3	50mg	QQ客服：1457312923
冬青素A	CFN93149	108524-94-3	100mg	QQ客服：1457312923

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Description:

Ilexgenin A exerts anti-inflammation and anti-angiogenesis effects through inhibition of STAT3 and PI3K pathways and exhibits synergistic effects with Sorafenib on hepatoma growth. It has anti-atherosclerotic activity, it shows reduction of atherosclerosis in apolipoprotein E deficient mice. Ilexgenin A is useful in the management of cardiovascular diseases in obesity, it inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK dependent manner. Ilexgenin A could be regarded as a promising agent for the treatment of melanoma, it exerts anti-melanoma activity by arresting the cell cycle at G0/G1 and regulating IL-6 and TNF-α production.

Targets:

AMPK | PKC | TNF-α | IL Receptor | ERK | IkB | STAT | PI3K | Caspase | VEGFR | LDL | Akt | NF-kB | ROS | AMPK | NO | NOS | IKK

In vitro:

Eur J Pharmacol. 2017 Oct 15;813:84-93.

Inhibition of lipolysis by ilexgenin A via AMPK activation contributes to the prevention of hepatic insulin resistance.[Pubmed: 28739087 ]

Adipose dysfunction links tightly to hepatic insulin resistance and gluconeogenesis. Ilexgenin A is reported with the ability to regulate lipid profile and protect the liver against high fat diet (HFD) -induced impairment.
METHODS AND RESULTS:
Here, we propose that Ilexgenin A ameliorates hepatic insulin signaling and gluconeogenesis by regulating lipolysis in white adipose tissue (WAT). Pyruvate tolerance test and biochemical analysis coupled with the ex vivo siRNA knockdown and co-culture studies demonstrate that Ilexgenin A suppresses inflammation-associated lipolysis in epididymal fat pad via 5'-AMP-activated protein kinase (AMPK) activation, thus inhibits diacylglycerol (DAG) accumulation and protein kinase C ε (PKCε) translocation in liver, leading to the improvement of insulin sensitivity and hepatic glucose production.
CONCLUSIONS:
These findings suggest that the relationship between adipose function and hepatic insulin action may be targeted by natural bioactive components for the potential treatment of hepatic insulin resistance related disorders.

In vivo:

Eur J Pharmacol. 2017 Feb 15;797:94-105.

Ilexgenin A, a novel pentacyclic triterpenoid extracted from Aquifoliaceae shows reduction of LPS-induced peritonitis in mice.[Pubmed: 28104349]

Ilexgenin A (IA) is a novel pentacyclic triterpenoid, which extracted from leaves of Ilex hainanensis Merr.
METHODS AND RESULTS:
In the present study, we aim to explore anti-inflammatory activity of IA on LPS-induced peritonitis and its underlying molecular mechanism. The results determined that IA was capable of suppressing peritonitis in mice induced by intraperitoneal (i.p.) injection of lipopolysaccaride (LPS). Furthermore, the results showed that IA dramatically inhibited levels of inflammatory cells infiltration in peritoneal cavity and serum in LPS-induced mice peritonitis model. Besides, IA could dramatically inhibit levels of inflammatory cytokines (IL-1β, IL-6 and TNF-α) in peritoneal cavity in LPS-induced mice peritonitis model. In vitro study, the results showed that IA inhibited production of IL-1β, IL-6 and TNF-α at transcriptional and translational levels in RAW 264.7 cells induced by LPS. Furthermore, IA could suppress the LPS-induced activation of Akt and downstream degradation and phosphorylation of kappa B-α (IκB-α). Moreover, IA could significantly inhibit ERK 1/2 phosphorylation in RAW 264.7 cells induced by LPS.
CONCLUSIONS:
These results were concurrent with molecular docking which revealed ERK1/2 inhibition. These results demonstrated that IA might as an anti-inflammatory agent candidate for inflammatory disease therapy.

Pharmacol Res. 2015 Sep;99:101-15.

Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK dependent manner.[Pubmed: 26054569 ]

Ilexgenin A is a natural triterpenoid with beneficial effects on lipid disorders. This study aimed to investigate the effects of Ilexgenin A on endothelial homeostasis and its mechanisms.
METHODS AND RESULTS:
Palmitate (PA) stimulation induced endoplasmic reticulum stress (ER stress) and subsequent thioredoxin-interacting protein (TXNIP)/NLRP3 inflammasome activation in endothelial cells, leading to endothelial dysfunction. Ilexgenin A enhanced LKB1-dependent AMPK activity and improved ER stress by suppression of ROS-associated TXNIP induction. However, these effects were blocked by knockdown of AMPKα, indicating AMPK is essential for its action in suppression of ER stress. Meanwhile, Ilexgenin A inhibited NLRP3 inflammasome activation by down-regulation of NLRP3 and cleaved caspase-1 induction, and thereby reduced IL-1β secretion. It also inhibited inflammation and apoptosis exposed to PA insult. Consistent with these results in endothelial cells, Ilexgenin A attenuated ER stress and restored the loss of eNOS activity in vascular endothelium, and thereby improved endothelium-dependent vasodilation in rat aorta. A further analysis in high-fat fed mice showed that oral administration of Ilexgenin A blocked ER stress/NLRP3 activation with reduced ROS generation and increased NO production in vascular endothelium, well confirming the beneficial effect of Ilexgenin A on endothelial homeostasis in vivo.
CONCLUSIONS:
Taken together, these results show ER stress-associated TXNIP/NLRP3 inflammasome activation was responsible for endothelial dysfunction and Ilexgenin A ameliorated endothelial dysfunction by suppressing ER-stress and TXNIP/NLRP3 inflammasome activation with a regulation of AMPK. This finding suggests that the application of Ilexgenin A is useful in the management of cardiovascular diseases in obesity.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9893 mL	9.9465 mL	19.893 mL	39.786 mL	49.7324 mL
5 mM	0.3979 mL	1.9893 mL	3.9786 mL	7.9572 mL	9.9465 mL
10 mM	0.1989 mL	0.9946 mL	1.9893 mL	3.9786 mL	4.9732 mL
50 mM	0.0398 mL	0.1989 mL	0.3979 mL	0.7957 mL	0.9946 mL
100 mM	0.0199 mL	0.0995 mL	0.1989 mL	0.3979 mL	0.4973 mL

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冬青素A

Ilexgenin A

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