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  • 荷茗草醌

    Horminone

    荷茗草醌
    产品编号 CFN98086
    CAS编号 21887-01-4
    分子式 = 分子量 C20H28O4 = 332.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The herbs of Salvia japonica Thunb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    荷茗草醌 CFN98086 21887-01-4 1mg QQ客服:2056216494
    荷茗草醌 CFN98086 21887-01-4 5mg QQ客服:2056216494
    荷茗草醌 CFN98086 21887-01-4 10mg QQ客服:2056216494
    荷茗草醌 CFN98086 21887-01-4 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Malaya (Malaysia)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Tokyo Woman's Christian University (Japan)
  • University of Fribourg (Switzerland)
  • Seoul National University (Korea)
  • Periyar University (India)
  • Technical University of Denmark (Denmark)
  • CSIRO - Agriculture Flagship (Australia)
  • Almansora University (Egypt)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Medizinische Universit?t Wien (Austria)
  • Universit?t Basel (Switzerland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Acta Chromatographica2021, 00960.
  • Planta Med.2018, 84(6-07):465-474
  • Front Aging Neurosci.2018, 10:269
  • J Pharm Biomed Anal.2019, 172:268-277
  • Regul Toxicol Pharmacol.2023, 142:105433.
  • Plants (Basel).2021, 10(4):702.
  • Biomed Pharmacother.2023, 163:114785.
  • Pharmacognosy Journal2019, 11(2): 369-373
  • J Plant Biotechnol.2023, 50:070-075.
  • UDC.2020, 19(4).
  • Green Chemistry2021, ISSUE 2.
  • Korean J. Medicinal Crop Sci.2022, 30(2):124-133
  • BMC Complement Altern Med.2017, 17(1):384
  • Phytomedicine2022, 104:154318
  • Phytochemistry.2017, 141:162-170
  • Plant Biotechnology Reports 2021, 15:117-124.
  • Processes2021, 9(1), 153;
  • J Separation Science & Technology2016, 51:1579-1588
  • Molecules.2021, 26(23):7390.
  • BMC Complement Altern Med.2018, 18(1):303
  • Biomedicine & Pharmacotherapy2022, 153:113404.
  • Korean J. Food Preserv.2023, 30(4):663-668.
  • Horticulture Research2023, uhad259
  • ...
  • 生物活性
    Description: Horminone has antimicrobial activity, it can inhibit the protein synthesis in several types of bacteria; it can inhibit the in vitro growth of Trypanosoma cruzi, 30 microM drug concentration producing total inhibition of growth. After administration of plant extracts containing Horminone has possibility of toxic effect.
    Targets: DNA/RNA Synthesis | NADPH-oxidase | Antifection
    In vitro:
    Experientia. 1985 May 15;41(5):646-8.
    Effect of tingenone, a quinonoid triterpene, on growth and macromolecule biosynthesis in Trypanosoma cruzi.[Pubmed: 3888660]

    METHODS AND RESULTS:
    Tingenone and horminone, two natural quinonoid substances, inhibited the in vitro growth of Trypanosoma cruzi, 30 microM drug concentration producing total inhibition of growth. Tingenone inhibited total uptake and incorporation of [3H]thymidine, [3H]uridine, L-[3H]leucine into parasite macromolecules. Other quinonoids assayed were either less effective (abruquinone A) or even quite inactive (visminone B and ferruginin B). Investigation of several mechanisms for the cytotoxic action of tingenone pointed to the interaction with DNA as the most likely factor involved.
    CONCLUSIONS:
    Tingenone also inhibited the growth of Crithidia fasciculata, but the drug was significantly less active on this organism than on T. cruzi.
    In vivo:
    J Ethnopharmacol. 1997 Sep;58(1):21-30.
    Effects of horminone on liver mixed function mono-oxygenases and glutathione enzyme activities of Wistar rat.[Pubmed: 9324001 ]
    The present study reports on the effects of Horminone on serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, on hepatic cytochrome P450 (P450) and cytochrome b5 (cyt b5) contents and on the activities of NADPH-cytochrome P450 reductase (NR), mixed function mono-oxygenases (MFO), glutathione-S-transferase (GST) and glutathione reductase (GR) of Wistar male rat. Horminone is a diterpenoid quinone (7,12-dihydroxyabiet-8,12-diene-11,14-dione) present in several species of the Labiatae family and used as medicinal plants in folk medicine.
    METHODS AND RESULTS:
    In this study, Horminone was administered by the intraperitoneal route (i.p.) at a concentration of 1 or 10 mg/kg to each group of six mice, using water as a vehicle. On the one hand, results showed that Horminone increased serum ALT and AST levels and cyt b5 content and induced the activities of ethylmorphine N-demethylase (EMD). On the other hand, Horminone decreased P450 content and inhibited the activities of 7-ethoxyresorufin O-deethylase (ERD), 7-ethoxycoumarin O-deethylase (ECD), aniline 4-hydroxylase (AH) and NR.
    CONCLUSIONS:
    Based on these results, the possibility of toxic effects occurring after administration of plant extracts containing Horminone must be considered.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0084 mL 15.0421 mL 30.0842 mL 60.1685 mL 75.2106 mL
    5 mM 0.6017 mL 3.0084 mL 6.0168 mL 12.0337 mL 15.0421 mL
    10 mM 0.3008 mL 1.5042 mL 3.0084 mL 6.0168 mL 7.5211 mL
    50 mM 0.0602 mL 0.3008 mL 0.6017 mL 1.2034 mL 1.5042 mL
    100 mM 0.0301 mL 0.1504 mL 0.3008 mL 0.6017 mL 0.7521 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    落叶松醌; Taxoquinone CFN96369 21764-41-0 C20H28O4 = 332.4 5mg QQ客服:2159513211
    脱氧基新隐丹参酮;新隐丹参酮II; Neocryptotanshinone II CFN92160 27468-20-8 C19H22O3 = 298.4 5mg QQ客服:215959384
    新隐丹参酮; Neocryptotanshinone CFN92181 109664-02-0 C19H22O4 = 314.4 10mg QQ客服:215959384
    罗列酮; Royleanone CFN96006 6812-87-9 C20H28O3 = 316.4 5mg QQ客服:1457312923
    荷茗草醌; Horminone CFN98086 21887-01-4 C20H28O4 = 332.4 5mg QQ客服:2159513211
    16-乙酰氧基-7-O-乙酰基荷茗草醌; 16-Acetoxy-7-O-acetylhorminone CFN98323 269742-39-4 C24H32O7 = 432.5 5mg QQ客服:1457312923
    纹香茶菜E; Lophanthoidin E CFN99318 120462-45-5 C22H30O7 = 406.5 5mg QQ客服:3257982914
    纹香茶菜F; Lophanthoidin F CFN99319 120462-46-6 C24H34O7 = 434.5 5mg QQ客服:2159513211
    纹香茶菜B; Lophanthoidin B CFN99317 120462-42-2 C24H32O8 = 448.5 5mg QQ客服:1413575084

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