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  • 去氢毛钩藤碱

    Hirsuteine

    去氢毛钩藤碱
    产品编号 CFN90615
    CAS编号 35467-43-7
    分子式 = 分子量 C22H26N2O3 = 366.45
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Uncaria rhynchophylla
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    去氢毛钩藤碱 CFN90615 35467-43-7 1mg QQ客服:2056216494
    去氢毛钩藤碱 CFN90615 35467-43-7 5mg QQ客服:2056216494
    去氢毛钩藤碱 CFN90615 35467-43-7 10mg QQ客服:2056216494
    去氢毛钩藤碱 CFN90615 35467-43-7 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • National Hellenic Research Foundation (Greece)
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  • National Cancer Center Research Institute (Japan)
  • Yale University (USA)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Monash University Sunway Campus (Malaysia)
  • Chinese University of Hong Kong (China)
  • University of Leipzig (Germany)
  • Gyeongsang National University (Korea)
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  • Helmholtz Zentrum München (Germany)
  • Regional Crop Research Institute (Korea)
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  • Worcester Polytechnic Institute (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Pharmacol.2023, 14:1244655.
  • JMSACL2023, 09.002
  • Food Research2022, 6(6): 30-38.
  • J Ethnopharmacol.2017, 198:205-213
  • Appl. Sci.2021, 11(24),12080
  • Plant Physiol Biochem.2023, 201:107795.
  • J Korean Soc Food Sci Nutr2023, 52(11):1101-1110
  • J Pharm Biomed Anal.2022, 207:114398.
  • J Agric Food Chem.2021, 69(46):14037-14047.
  • Fitoterapia.2021, 153:104995.
  • Neurotox Res.2020, 38(1):163-174.
  • Molecules.2021, 26(9):2791.
  • Biosci Rep.2020, 40(8):BSR20201219.
  • Int. J. Mol. Sci.2022, 23(19), 11900.
  • J Bone Miner Res.2017, 32(12):2415-2430
  • Biosci Biotechnol Biochem.2021, 85(10):2153-2160.
  • Life (Basel).2022, 12(10):1630.
  • Biomolecules2021, 11(10),1513.
  • Molecules.2019, 24(4):E709
  • J Ethnopharmacol.2017, 197:157-164
  • Korean Journal of Pharmacognosy2014, 113-120
  • Nutrients2020, 12(2):488
  • Int. J. Mol. Sci.2022, 23(8), 4130.
  • ...
  • 生物活性
    Description: Hirsuteine exhibits potent neuroprotective effects against glutamate-induced HT22 cell death. Hirsuteine non-competitively antagonizes nicotine-evoked dopamine release by blocking ion permeation through nicotinic receptor channel complexes.
    Targets: Dopamine Receptor
    In vitro:
    Jpn J Pharmacol. 1993 Apr;61(4):351-6.
    Non-competitive antagonism by hirsuteine of nicotinic receptor-mediated dopamine release from rat pheochromocytoma cells.[Pubmed: 8320880]
    Effects of hirsuteine, an indole alkaloid extracted from Uncaria genus, on nicotine- and high K-induced responses were investigated in rat pheochromocytoma PC12 cells.
    METHODS AND RESULTS:
    Hirsuteine (300 nM-10 microM) inhibited dopamine release evoked by 100 microM nicotine in a concentration-dependent manner. Hirsuteine did not produce a parallel shift of the concentration-response relationship curve for nicotine, but reduced maximal dopamine release. Dopamine release evoked by 60 and 155 mM KCl was also inhibited by hirsuteine, but the concentration necessary for significant inhibition was higher (more than 10 microM). Under whole cell voltage-clamp, hirsuteine reversibly inhibited inward currents activated by 100 microM nicotine. The current inhibition was slightly accelerated by hyperpolarization.
    CONCLUSIONS:
    The results suggest that hirsuteine non-competitively antagonizes nicotine-evoked dopamine release by blocking ion permeation through nicotinic receptor channel complexes. The blockade of Ca channels, which are activated during nicotine-evoked depolarization, may not play a major role in the antagonism.
    J Asian Nat Prod Res. 2014;16(8):876-83.
    Alkaloids from the hook-bearing branch of Uncariarhynchophylla and their neuroprotective effects against glutamate-induced HT22 cell death.[Pubmed: 24899363]

    METHODS AND RESULTS:
    One new alkaloid, 4-geissoschizine N-oxide methyl ether (1), was isolated from the EtOH extract of the hook-bearing branch of Uncariarhynchophylla, together with 10 known alkaloids, 3-epi-geissoschizine methyl ether (2) isolated from U.rhynchophylla for the first time, geissoschizine methyl ether (3), 4-Hirsuteine N-oxide (4), Hirsuteine (5), hirsutine (6), 3α-dihydro-cadambine (7), 3β-isodihydro-cadambine (8), cadambine (9), strictosamide (10), and akuammigine (11). The structures were elucidated by spectroscopic methods including UV, ESI-QTOF MS, NMR, and circular dichroism experiments. Neuroprotective effects of 1-9 were investigated against 3 mM glutamate-induced HT22 cell death.
    CONCLUSIONS:
    The activity assay showed that 2, 3, 5, and 6 exhibited potent neuroprotective effects against glutamate-induced HT22 cell death. However, only weak neuroprotective activities were observed for 1, 4, 7, 8, and 9.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7289 mL 13.6444 mL 27.2889 mL 54.5777 mL 68.2221 mL
    5 mM 0.5458 mL 2.7289 mL 5.4578 mL 10.9155 mL 13.6444 mL
    10 mM 0.2729 mL 1.3644 mL 2.7289 mL 5.4578 mL 6.8222 mL
    50 mM 0.0546 mL 0.2729 mL 0.5458 mL 1.0916 mL 1.3644 mL
    100 mM 0.0273 mL 0.1364 mL 0.2729 mL 0.5458 mL 0.6822 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    缝籽嗪; Geissoschizine CFN95566 439-66-7 C21H24N2O4 = 368.4 5mg QQ客服:1413575084
    缝籽木蓁甲醚; Geissoschizine methyl ether CFN89459 60314-89-8 C22H26N2O3 = 366.45 10mg QQ客服:1457312923
    西特斯日钦碱; Sitsirikine CFN96218 1245-00-7 C21H26N2O3 = 354.5 5mg QQ客服:2159513211
    去氢毛钩藤碱; Hirsuteine CFN90615 35467-43-7 C22H26N2O3 = 366.45 5mg QQ客服:1413575084
    毛钩藤碱; Hirsutine CFN90617 7729-23-9 C22H28N2O3 = 368.47 5mg QQ客服:1457312923
    (16R)-二氢西特斯日钦碱; (16R)-Dihydrositsirikine CFN97115 6519-26-2 C21H28N2O3 = 356.5 5mg QQ客服:2159513211
    异长春花苷内酰胺; Strictosamide CFN98237 23141-25-5 C26H30N2O8 = 498.5 10mg QQ客服:2056216494
    喜果苷; Vincosamide CFN98238 23141-27-7 C26H30N2O8 = 498.5 10mg QQ客服:3257982914
    Strictosidinic acid; Strictosidinic acid CFN96657 150148-81-5 C26H32N2O9 = 516.54 5mg QQ客服:2056216494
    3Beta-异二氢卡丹宾碱 4-氧化物; 3Beta-Isodihydrocadambine 4-oxide CFN92745 1092371-18-0 C27H34N2O11 = 562.6 5mg QQ客服:215959384

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