| Food Chem. 2012 Nov 15;135(2):332-7. |
| In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin.[Pubmed: 22868095] |
Hexahydrocurcumin, 1-dehydro-[6]-gingerdione, 6-dehydroshogaol and 6-shogaol were evaluated for their antioxidant and anti-inflammatory activities in the present study.
METHODS AND RESULTS:
The relative antioxidant potencies of ginger compounds decreased in similar order of 1-dehydro-[6]-gingerdione, hexahydrocurcumin>6-shogaol>6-dehydroshogaol in both 1,1-diphenyl-2-picyrlhydrazyl (DPPH) radical-scavenging and trolox equivalent antioxidant capacity (TEAC) assays. All tested compounds could attenuate lipopolysaccharide (LPS)-elicited increase of prostaglandin E2 (PGE(2)) in murine macrophages (RAW 264.7) in a concentration-dependent manner but hexahydrocurcumin of 7μM and 6-shogaol of 7μM. The strongest inhibitory effect was observed for 6-dehydroshogaol and 6-shogaol at 14μM with the inhibition of 53.3% and 48.9%, respectively. Furthermore, both 6-dehydroshogaol and 1-dehydro-[6]-gingerdione significantly suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins in a concentration-dependent fashion.
CONCLUSIONS:
These results contribute to our theoretical understanding of the potential beneficial effects of consuming ginger as a food and/or dietary supplement. |
| Nat Prod Commun. 2012 Jul;7(7):883-4. |
| Inhibitory effect of hexahydrocurcumin on human platelet aggregation.[Pubmed: 22908571] |
The effects of hexahydrocurcumin on adenosine diphosphate (ADP)-induced human platelet aggregation were studied.
METHODS AND RESULTS:
Treatment of human platelet-rich plasma with hexahydrocurcumin resulted in an inhibitory effect on platelet aggregation, suggesting the potential of this compound as an anti-atherosclerogenic agent in humans. |
| Nat Prod Commun. 2011 Nov;6(11):1671-2. |
| Cytotoxic activity and cell cycle analysis of hexahydrocurcumin on SW 480 human colorectal cancer cells.[Pubmed: 22224285] |
The cytotoxicity of Hexahydrocurcumin and its effect on the cell cycle in human colorectal cancer cells SW480 has been studied for the first time.
METHODS AND RESULTS:
The compound, extracted from Zingiber officinale, was shown to be cytotoxic to colorectal cancer cells. Treatment of SW480 cells with Hexahydrocurcumin (100 microM) resulted in a massive accumulation of the cells in the G1/G0 phase of the cell cycle.
CONCLUSIONS:
The cytotoxic effect of Hexahydrocurcumin may prove useful in cancer prevention. |
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