Heliangin

	产品编号	CFN96222
	CAS编号	13323-48-3
	分子式 = 分子量	C₂₀H₂₆O₆ = 362.4
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Sesquiterpenoids
	植物来源	The herbs of Helianthus tuberosus L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Heliangin	CFN96222	13323-48-3	1mg	QQ客服：1457312923
Heliangin	CFN96222	13323-48-3	5mg	QQ客服：1457312923
Heliangin	CFN96222	13323-48-3	10mg	QQ客服：1457312923
Heliangin	CFN96222	13323-48-3	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universidade Federal de Santa Catarina (Brazil)

Warszawski Uniwersytet Medyczny (Poland)

Institute of Pathophysiology Medical University of Vienna (Austria)

Indian Institute of Science (India)

University of Hawaii Cancer Center (USA)

Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)

Universidad de La Salle (Mexico)

Wroclaw Medical University (Poland)

University of British Columbia (Canada)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

Calcutta University (India)

University of Auckland (New Zealand)

University of Amsterdam (Netherlands)

Mahatma Gandhi University (India)

More...

Description:

Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cells. Heliangin has anti-cancer activity, it exhibits cytotoxicity against human oral epidermoid (KB), cervical epitheloid (Hela), and liver (hepa59T/VGH) carcinoma cells.

Targets:

MAPK | NF-kB | TNF-α | IL Receptor | PGE

In vivo:

Biomed Pharmacother. 2017 Apr;88:102-8.

Heliangin inhibited lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cells.[Pubmed: 28095354 ]

The Heliangin is a natural agent mainly isolated from Helianthus tuberosus L. (Asteraceae). In order to investigate the anti-inflammatory effect of Heliangin, several typical models in vivo and in vitro were performed.
METHODS AND RESULTS:
The RAW264.7 mouse macrophages cells were employed in vitro and dexamethasone were conducted as positive. The cytotoxicity results of Heliangin on RAW 264.7 cells provided the safety in vitro for further study.Moreover, we founded that MAPK and NF-κB signaling pathway play important roles in Heliangin's activity on RAW264.7 cells. Secondly, the acute toxic study results of Heliangin manifested the safety in vivo. Heliangin exerted anti-inflammation effect in a xylene-induced ear swelling in BALB/C mice and carrageenan-induced paw edema model in SD rats. The cytokines levels (TNF-α, IL-6 and PGE2) were decreased.
CONCLUSIONS:
The paw tissue immunochemistry assay demonstrated the IL-6 protein level changes in carrageenan-induced paw edema model under Heliangin administration.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
地胆草种内酯; Scabertopin	CFN97798	185213-52-9	C₂₀H₂₂O₆ = 358.39	5mg	QQ客服：2056216494
异地胆草种内酯; Isoscabertopin	CFN97740	439923-16-7	C₂₀H₂₂O₆ = 358.39	5mg	QQ客服：1457312923
8beta-(4'-Hydroxytigloyloxy)costunolide; 8beta-(4'-Hydroxytigloyloxy)costunolide	CFN92903	94190-32-6	C₂₀H₂₆O₅ = 346.42	5mg	QQ客服：215959384
Neobritannilactone B; Neobritannilactone B	CFN92602	886990-00-7	C₁₅H₂₀O₃ = 248.3	5mg	QQ客服：3257982914
2alpha-羟基泽兰内酯; 2-Hydroxyeupatolide	CFN90346	72229-33-5	C₁₅H₂₀O₄ = 264.32	5mg	QQ客服：1457312923
表美国鹅掌楸内酯; Epitulipinolide	CFN98252	24164-13-4	C₁₇H₂₂O₄ = 290.4	5mg	QQ客服：1413575084
小白菊内酯; Parthenolide	CFN98034	20554-84-1	C₁₅H₂₀O₃ = 248.3	20mg	QQ客服：2056216494
鹅掌揪内酯; Lipiferolide	CFN98642	41059-80-7	C₁₇H₂₂O₅ = 306.4	5mg	QQ客服：215959384
环氧表美国鹅掌楸内酯; Epitulipinolide diepoxide	CFN98630	39815-40-2	C₁₇H₂₂O₆ = 322.4	5mg	QQ客服：215959384
Heliangin; Heliangin	CFN96222	13323-48-3	C₂₀H₂₆O₆ = 362.4	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7594 mL	13.7969 mL	27.5938 mL	55.1876 mL	68.9845 mL
5 mM	0.5519 mL	2.7594 mL	5.5188 mL	11.0375 mL	13.7969 mL
10 mM	0.2759 mL	1.3797 mL	2.7594 mL	5.5188 mL	6.8985 mL
50 mM	0.0552 mL	0.2759 mL	0.5519 mL	1.1038 mL	1.3797 mL
100 mM	0.0276 mL	0.138 mL	0.2759 mL	0.5519 mL	0.6898 mL