| In vitro: |
| J Appl Microbiol. 2006 Aug;101(2):487-95. | | Guaijaverin -- a plant flavonoid as potential antiplaque agent against Streptococcus mutans.[Pubmed: 16882158] | The aim of the present study was to investigate the anti-Streptococcus mutans activity and the in vitro effects of subminimal inhibitory concentrations of guaijaverin isolated from Psidium guajava Linn. on cariogenic properties of Strep. mutans.
METHODS AND RESULTS:
Bioautography-directed chromatographic fractionation, yield biologically active compound, quercetin-3-O-alpha-l-arabinopyranoside (guaijaverin), from crude methanol extract of P. guajava. Growth-inhibitory activity of the compound against Strep. mutans of both clinical and type strain cultures was evaluated. The anti-Strep. mutans activity of the guaijaverin was found to be bacteriostatic, both heat and acid stable and alkali labile with the minimum inhibitory concentration (MIC) of 4 mg ml(-1) for MTCC 1943 and 2 mg ml(-1) for CLSM 001. The sub-MIC concentrations (0.0078-2 mg ml(-1)) of the guaijaverin were evaluated for its cariogenic properties such as acid production, cell-surface hydrophobicity, sucrose-dependent adherence to glass surface and sucrose-induced aggregation of Strep. mutans.
CONCLUSIONS:
The active flavonoid compound, quercetin-3-O-alpha-l-arabinopyranoside (guaijaverin) demonstrated high potential antiplaque agent by inhibiting the growth of the Strep. mutans.
This study demonstrated the new growth-inhibitory compound guaijaverin against Strep. mutans and led to the acceptance of traditional medicine and natural products as an alternative form of health care. | | Food Science, 2016, 37(7):168-74. | | Hypoglycemic Activity of Avicularin and Guaijaverin in Guava Leaves.[Reference: WebLink] | To study the hypoglycemic activity of avicularin and Guaijaverin in guava leaves.
METHODS AND RESULTS:
Reversedphase high performance liquid chromatography(RP-HPLC) was used to determine the content of avicularin and Guaijaverin in guava leaves in different months of the year. The fat cell model was established to evaluate hypoglycemic activity of the ethanol extract of guava leaves, avicularin and Guaijaverin respectively. Western blotting was used to analyze GLUT4 expression on the fat cell membrane. Free fatty acids as another index were also determined using a fatty acid kit. The contents of Guaijaverin and avicularin in guava leaves showed great difference in different months, and guava leaves had higher contents and hypoglycemic activity both between June and September. The guava leaf extract, guajava and avicularin could all significantly promote GLUT4 protein expression on the fat cell membrane and significantly inhibit the release of free fatty acids.
CONCLUSIONS:
Guaijaverin and avicularin are the major bioactive components in guava leaves with hypoglycemic activity and inhibitory capacity against free fatty acid release. |
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