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  • 甘草次酸; beta-甘草亭酸

    Glycyrrhetinic acid

    甘草次酸; beta-甘草亭酸
    产品编号 CFN99152
    CAS编号 471-53-4
    分子式 = 分子量 C30H46O4 = 470.64
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Glycyrrhize glabra L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    甘草次酸; beta-甘草亭酸 CFN99152 471-53-4 10mg QQ客服:3257982914
    甘草次酸; beta-甘草亭酸 CFN99152 471-53-4 20mg QQ客服:3257982914
    甘草次酸; beta-甘草亭酸 CFN99152 471-53-4 50mg QQ客服:3257982914
    甘草次酸; beta-甘草亭酸 CFN99152 471-53-4 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universitas Airlangga (Indonesia)
  • Univerzita Karlova v Praze (Czech Republic)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • University of Fribourg (Switzerland)
  • Max Rubner-Institut (MRI) (Germany)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Institute of Chinese Materia Medica (China)
  • Auburn University (USA)
  • University of Pretoria (South Africa)
  • University of Stirling (United Kingdom)
  • Technical University of Denmark (Denmark)
  • Chinese University of Hong Kong (China)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Nanjing University of Chinese Medicine (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nutr Res Pract.2023, 17(4):670-681.
  • Pol J Microbiol.2021, 70(1):117-130.
  • The Korea Journal of Herbology2020, 35(3):33-45.
  • Molecules.2019, 24(11):E2102
  • Fitoterapia.2021, 153:104995.
  • Evid Based Complement Alternat Med.2021, 8707280.
  • Molecules.2020, 25(9):2111.
  • Drug Des Devel Ther.2023, 17:2461-2479.
  • Molecules2022, 27(9):2613.
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
  • Int J Mol Sci.2019, 20(16):E4015
  • Viruses.2017, 9(10)
  • Planta Med.2018, 84(6-07):465-474
  • J Cell Physiol.2020, 10.1002
  • J Agric Food Chem.2021, 69(11):3496-3510.
  • Food Chem.2019, 290:286-294
  • Int J Mol Sci.2018, 19(9):E2681
  • Mol Pharm.2018, 15(8):3285-3296
  • Universidade Estadual Paulista2017, 42785
  • Acta Physiologiae Plantarum2015, 37:1736
  • Molecules 2021, 26(4),1092.
  • TCI CO.2019, US20190151257A1
  • J Sep Sci.2018, 41(11):2488-2497
  • ...
  • 生物活性
    Description: Glycyrrhetinic acid, an AChE activator, has anti-inflammatory,and antileukaemic activities. It is a potent inducer of mitochondrial permeability transition and can trigger the pro-apoptotic pathway, it has a low but definite affinity for mineralocorticoid receptors and thus appears to have a direct mineralocorticoid action.
    Targets: PERK | CDK | E2F‑1 | AChR
    In vitro:
    Int J Oncol. 2015 Mar;46(3):981-8.
    Glycyrrhetinic acid induces G1‑phase cell cycle arrest in human non‑small cell lung cancer cells through endoplasmic reticulum stress pathway.[Pubmed: 25573651]
    Glycyrrhetinic acid (GA) is a natural compound extracted from liquorice, which is often used in traditional Chinese medicine.
    METHODS AND RESULTS:
    The purpose of the present study was to investigate the antitumor effect of GA in human non‑small cell lung cancer (NSCLC), and its underlying mechanisms in vitro. We have shown that GA suppressed the proliferation of A549 and NCI‑H460 cells. Flow cytometric analysis showed that GA arrested cell cycle in G0/G1 phase without inducing apoptosis. Western blot analysis indicated that GA mediated G1‑phase cell cycle arrest by upregulation of cyclin‑dependent kinase inhibitors (CKIs) (p18, p16, p27 and p21) and inhibition of cyclins (cyclin‑D1, ‑D3 and ‑E) and cyclin‑dependent kinases (CDKs) (CDK4, 6 and 2). GA also maintained pRb phosphorylation status, and inhibited E2F transcription factor 1 (E2F‑1) in both cell lines. GA upregulated the unfolded proteins, Bip, PERK and ERP72. Accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggered the unfolded protein response (UPR), which could be the mechanism by which GA inhibited cell proliferation in NSCLC cells. GA then coordinated the induction of ER chaperones, which decreased protein synthesis and induced cell cycle arrest in the G1 phase.
    CONCLUSIONS:
    This study provides experimental evidence to support the development of GA as a chemotherapeutic agent for NSCLC.
    Biochem Pharmacol. 2003 Dec 15;66(12):2375-9.
    Glycyrrhetinic acid-induced permeability transition in rat liver mitochondria.[Pubmed: 14637195]
    Glycyrrhetinic acid, a hydrolysis product of one of the main constituents of licorice, the triterpene glycoside of glycyrrhizic acid, when added to rat liver mitochondria at micromolar concentrations induces swelling, loss of membrane potential, pyridine nucleotide oxidation, and release of cytochrome c and apoptosis inducing factor. These changes are Ca(2+) dependent and are prevented by cyclosporin A, bongkrekic acid, and N-ethylmaleimide. All these observations indicate that glycyrrhetinic acid is a potent inducer of mitochondrial permeability transition and can trigger the pro-apoptotic pathway.
    In vivo:
    J. Pharm. Pharmacol., 2011, 10(1):613-20.
    The antiinflammatory activity of glycyrrhetinic acid and derivatives.[Reference: WebLink]
    The anti-inflammatory activities of different fractions of glycyrrhetinic acid or glycyrrhetic acid and some of its derivatives have been assessed in laboratory animals. Some, but not all, preparations have been found to be active using four established methods for testing anti-inflammatory drugs. The findings provide a scientific basis for the clinical use of these compounds in inflammatory diseases, and may explain the discrepancies in the early clinical trials with this drug.
    Evid Based Complement Alternat Med . 2017;2017:3470320.
    Protective Effect of 18 β-Glycyrrhetinic Acid against Triptolide-Induced Hepatotoxicity in Rats[Pubmed: 28572827]
    Abstract Triptolide (TP) is the major active component of Tripterygium wilfordii Hook F (TWHF) and possesses multiple pharmacological effects. However, hepatotoxicity of TP which is one of the toxic properties slows its progression in clinical application. 18β-Glycyrrhetinic acid (GA) is the main bioactive ingredient of Licorice (Glycyrrhiza glabra L.), a herbal medicine famous for its detoxification. This study aims to investigate whether GA possesses protective effect against TP-induced hepatotoxicity in rats. TP interference markedly elevated serum levels of ALT, AST, and ALP, caused evident liver histopathological changes, and elevated hepatic TNF-α, IL-6, IL-1β, and IFN-γ as well as nuclear translocation of NF-κB. TP also significantly elevated liver MDA and declined hepatic activities of SOD, CAT, and GSH-Px. Assay of TUNEL and apoptosis proteins (Bax, Bcl-2, and active caspase-3) showed that TP induced severe hepatocellular apoptosis. In contrast, low-dose GA (50 mg/kg) significantly reversed TP-induced changes above. However, high-dose GA (100 mg/kg) had no such effect. Overall, these findings indicated that low-dose GA but not high-dose GA exhibited a protective effect against TP-induced hepatotoxicity in rats by anti-inflammation, antioxidation, and antiapoptosis, which suggests that the doses of GA/Licorice should be carefully considered when used together with TWHF or TWHF preparations.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1248 mL 10.6238 mL 21.2477 mL 42.4953 mL 53.1192 mL
    5 mM 0.425 mL 2.1248 mL 4.2495 mL 8.4991 mL 10.6238 mL
    10 mM 0.2125 mL 1.0624 mL 2.1248 mL 4.2495 mL 5.3119 mL
    50 mM 0.0425 mL 0.2125 mL 0.425 mL 0.8499 mL 1.0624 mL
    100 mM 0.0212 mL 0.1062 mL 0.2125 mL 0.425 mL 0.5312 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    甘草次酸; beta-甘草亭酸; Glycyrrhetinic acid CFN99152 471-53-4 C30H46O4 = 470.64 20mg QQ客服:2159513211
    28-羟基-3-氧代齐墩果-12-烯-29-酸; 28-Hydroxy-3-oxoolean-12-en-29-oic acid CFN97747 381691-22-1 C30H46O4 = 470.69 5mg QQ客服:2159513211
    22-羟基-3-氧代齐墩果-12-烯-29-酸; 22-Hydroxy-3-oxoolean-12-en-29-oic acid CFN99487 144629-84-5 C30H46O4 = 470.7 5mg QQ客服:1413575084
    3,22-二羟基齐墩果-12-烯-29-酸; 3,22-Dihydroxyolean-12-en-29-oic acid CFN97288 808769-54-2 C30H48O4 = 472.7 5mg QQ客服:215959384
    Triptocallic acid D; Triptocallic acid D CFN98018 201534-09-0 C30H48O4 = 472.7 5mg QQ客服:215959384
    雷公藤三萜酸A; Triptotriterpenic acid A CFN96474 84108-17-8 C30H48O4 = 472.70 5mg QQ客服:215959384
    雷公藤内酯甲; 雷公藤内酯A; Wilforlide A CFN97335 84104-71-2 C30H46O3 = 454.7 20mg QQ客服:2056216494
    乙酸雷公藤内酯A; Wilforlide A acetate CFN97336 84104-80-3 C32H48O4 = 496.7 5mg QQ客服:1413575084
    美登木酸 ; Polpunonic acid CFN96834 33600-93-0 C30H48O3 = 456.71 5mg QQ客服:1457312923
    大子五层龙酸; Salaspermic acid CFN96837 71247-78-4 C30H48O4 = 472.71 5mg QQ客服:1413575084

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