甘氨酸

Glycine

	产品编号	CFN70144
	CAS编号	56-40-6
	分子式 = 分子量	C₂H₅NO₂ = 75.0
	产品纯度	>=98%
	物理属性	Oil
	化合物类型	Alkaloids
	植物来源	The seeds of Glycine max (Linn.) Merr.）
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
甘氨酸	CFN70144	56-40-6	10mg	QQ客服：2056216494
甘氨酸	CFN70144	56-40-6	20mg	QQ客服：2056216494
甘氨酸	CFN70144	56-40-6	50mg	QQ客服：2056216494
甘氨酸	CFN70144	56-40-6	100mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Hertfordshire (United Kingdom)

Chang Gung University (Taiwan)

Charles University in Prague (Czech Republic)

University of Ioannina (Greece)

St. Jude Children Research Hospital (USA)

University of Zurich (Switzerland)

University of Wuerzburg (Germany)

Charles Sturt University (Denmark)

Uniwersytet Gdański (Poland)

VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)

Deutsches Krebsforschungszentrum (Germany)

University of Illinois (USA)

Universidad Industrial de Santander (Colombia)

John Innes Centre (United Kingdom)

More...

Description:

Glycine is an inhibitory transmitter, it may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor.

Targets:

NMDA

In vitro:

Nature,1987 Feb 5-11;325(6104):529-31.

Glycine Potentiates the NMDA Response in Cultured Mouse Brain Neurons.[Reference: WebLink]

Transmitters mediating 'fast' synaptic processes in the vertebrate central nervous system are commonly placed in two separate categories that are believed to exhibit no interaction at the receptor level. The 'inhibitory transmitters' (such as glycine and GABA) are considered to act only on receptors mediating a chloride conductance increase, whereas 'excitatory transmitters' (such as L-glutamate) are considered to activate receptors mediating a cationic conductance increase. The best known excitatory receptor is that specifically activated by N-methyl-D-aspartate (NMDA) which has recently been characterized at the single channel level. The response activated by NMDA agonists is unique in that it exhibits a voltage-dependent Mg block.
METHODS AND RESULTS:
We report here that this response exhibits another remarkable property: it is dramatically potentiated by glycine. This potentiation is not mediated by the inhibitory strychnine-sensitive glycine receptor, and is detected at a glycine concentration as low as 10 nM. The potentiation can be observed in outside-out patches as an increase in the frequency of opening of the channels activated by NMDA agonists.
CONCLUSIONS:
Thus, in addition to its role as an inhibitory transmitter, glycine may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
20(S),24(R)-拟人参皂苷元; 20(S),24(R)-Ocotillol	CFN93850	69926-31-4	C₃₀H₅₂O₅ = 492.7	5mg	QQ客服：1413575084
芸香霉素，芸香亭; Rutaretin	CFN97825	13895-92-6	C₁₄H₁₄O₅ = 262.26	5mg	QQ客服：1457312923
Gnetofuran B; Gnetofuran B	CFN89489	526214-79-9	C₁₆H₁₄O₅ = 286.27	5mg	QQ客服：2056216494
Dorsomorphin dihydrochloride; Dorsomorphin dihydrochloride	CFN60096	1219168-18-9	C₂₄H₂₅N₅O.₂HCl = 472.41	5mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	13.3333 mL	66.6667 mL	133.3333 mL	266.6667 mL	333.3333 mL
5 mM	2.6667 mL	13.3333 mL	26.6667 mL	53.3333 mL	66.6667 mL
10 mM	1.3333 mL	6.6667 mL	13.3333 mL	26.6667 mL	33.3333 mL
50 mM	0.2667 mL	1.3333 mL	2.6667 mL	5.3333 mL	6.6667 mL
100 mM	0.1333 mL	0.6667 mL	1.3333 mL	2.6667 mL	3.3333 mL