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  • 粗毛甘草素F

    Glyasperin F

    粗毛甘草素F
    产品编号 CFN94013
    CAS编号 145382-61-2
    分子式 = 分子量 C20H18O6 = 354.35
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Glycyrrhiza aspera Pall.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    粗毛甘草素F CFN94013 145382-61-2 1mg QQ客服:2159513211
    粗毛甘草素F CFN94013 145382-61-2 5mg QQ客服:2159513211
    粗毛甘草素F CFN94013 145382-61-2 10mg QQ客服:2159513211
    粗毛甘草素F CFN94013 145382-61-2 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Oslo (Norway)
  • University of Toulouse (France)
  • Imperial College London (United Kingdom)
  • University of the Basque Country (Spain)
  • Max Rubner-Institut (MRI) (Germany)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Deutsches Krebsforschungszentrum (Germany)
  • University of Minnesota (USA)
  • Ateneo de Manila University (Philippines)
  • Subang Jaya Medical Centre (Malaysia)
  • University of Otago (New Zealand)
  • Regional Crop Research Institute (Korea)
  • University of Wollongong (Australia)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2019, 24(16):E3003
  • J Sep Sci.2020, 201901140
  • LWT2020, 110397
  • Anat Rec2018, 24264
  • Phytomedicine.2019, 59:152785
  • Mol Med Rep.2024, 29(2):26.
  • Metabolites.2020, 10(11):440.
  • Korean J. Food Preserv.2023, 30(4):663-668.
  • JMicrobiol Biotech Food Sci2021, e4289.
  • Ann Transl Med.2019, 7(23):731
  • Invest New Drugs.2017, 35(2):166-179
  • Korean J. Medicinal Crop Sci2021, 10:345-352.
  • Biosci Rep.2020, 40(8):BSR20201219.
  • Foods.2022, 11(12):1773.
  • Molecules2022, 27(11):3606.
  • Front Pharmacol.2018, 9:756
  • Plants (Basel).2021, 10(6):1192.
  • Chem. of Vegetable Raw Materials2020, 97-105
  • Univerzita Karlova2021, 20.500.11956.
  • Food Res Int.2020, 133:109130.
  • J Mol Med (Berl).2018, 96(7):661-672
  • Evid Based Complement Alternat Med.2021, 2021:5585692.
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • ...
  • 生物活性
    Description: Glyasperin F has antinociceptive, and anti-inflammatory effects, it could inhibit NO production in RAW 264.7 macrophages to some extent. Glyasperin F displayed cytotoxic effects against the four tested cancer cell lines with IC50values below 85 μM.
    Targets: NO
    In vitro:
    Chinese Traditional and Herbal Drugs, 2016.
    Study on active constituents from Glycyrrhizae Radix et Rhizoma against NO production in LPS-induced RAW264.7 macrophages.[Reference: WebLink]
    To study the anti-inflammatory constituents in Glycyrrhizae Radix et Rhizoma.
    METHODS AND RESULTS:
    The compounds were isolated and purified by means of macroporous resin, ODS column chromatography, and semi-preparative HPLC. And their structures were identified by LC-MS, 1H-NMR, and 13C-NMR. The anti-inflammatory activities of the compounds were evaluated on LPS-induced NO production in RAW 264.7 macrophages.Their structures were identified as liquiritin(1), liquiritin apioside(2), isoliquiritin(3), isoliquiritin apioside(4), sophoraisoflavone A(5), glyasperin F(6), glabrone(7), glabridin(8), licoflavonol(9), and glyasperin D(10).
    CONCLUSIONS:
    Compounds 1, 3, 5, 6, 8, and 9 could inhibit NO production in RAW 264.7 macrophages to some extent. And the anti-inflammatory effects of compounds 5, 6, and 9 are first reported in this work.
    Bmc Complementary & Alternative Medicine, 2018, 18(1):36.
    Cytotoxicity of seputhecarpan D, thonningiol and 12 other phytochemicals from African flora towards human carcinoma cells.[Reference: WebLink]
    Despite the remarkable progress in cancer therapy in recent years, this disease still remains a serious public health concern. The use of natural products has been and continues to be one of the most effective ways to fight malignancies. The cytotoxicity of 14 compounds from African medicinal plants was evaluated in four human carcinoma cell lines and normal fibroblasts. The tested samples included: β-spinasterol (1), friedelanone (2), 16β-hydroxylupeol (3), β-amyrin acetate (4), lupeol acetate (5), sequoyitol (6), rhamnitrin (7), europetin 3-O-rhamnoside (8), thonningiol (9), glyasperin F (10), seputhecarpan B (11), seputhecarpan C (12), seputhecarpan D (13) and rheediaxanthone A (14).
    METHODS AND RESULTS:
    The neutral red uptake (NR) assay was used to evaluate the cytotoxicity of samples; caspase-Glo assay, flow cytometry for cell cycle analysis and mitochondrial membrane potential (MMP) as well as spectrophotometry to measure levels of reactive oxygen species (ROS) were performed to detect the mode of action of compounds 9 and 13 in MCF-7 breast adenocarcinoma cells.Compounds 3, 9-13 displayed cytotoxic effects against the four tested cancer cell lines with IC50values below 85 μM. Compounds 9 and 13 had IC50values below 10 μM in 4/4 and 3/4 tested cell lines respectively. The IC50values varied from 0.36 μM (against MCF7 cells) to 5.65 μM (towards colon carcinoma DLD-1 cells) for 9, from 9.78 μM (against MCF7 cells) to 67.68 μM (against HepG2 cells) for 13 and 0.18 μM (towards HepG2 cells) to 72 μM (towards Caco-2 cells) for the reference drug, doxorubicin. Compounds 9 and 13 induced cell cycle arrest in Go/G1 whilst doxorubicin induced arrest in G2/M. The two molecules (9 and 13) also induced apoptosis in MCF-7 cells through activation of caspases 3/7 and 9 as well as enhanced ROS production.
    CONCLUSIONS:
    Compounds 9 and 13 are good cytotoxic phytochemicals that should be explored more in future to develop a cytotoxic drug to fight human carcinoma.
    Bmc Complementary & Alternative Medicine, 2018, 18(1):36.
    Cytotoxicity of seputhecarpan D, thonningiol and 12 other phytochemicals from African flora towards human carcinoma cells.[Reference: WebLink]
    Despite the remarkable progress in cancer therapy in recent years, this disease still remains a serious public health concern. The use of natural products has been and continues to be one of the most effective ways to fight malignancies. The cytotoxicity of 14 compounds from African medicinal plants was evaluated in four human carcinoma cell lines and normal fibroblasts. The tested samples included: β-spinasterol (1), friedelanone (2), 16β-hydroxylupeol (3), β-amyrin acetate (4), lupeol acetate (5), sequoyitol (6), rhamnitrin (7), europetin 3-O-rhamnoside (8), thonningiol (9), glyasperin F (10), seputhecarpan B (11), seputhecarpan C (12), seputhecarpan D (13) and rheediaxanthone A (14).
    METHODS AND RESULTS:
    The neutral red uptake (NR) assay was used to evaluate the cytotoxicity of samples; caspase-Glo assay, flow cytometry for cell cycle analysis and mitochondrial membrane potential (MMP) as well as spectrophotometry to measure levels of reactive oxygen species (ROS) were performed to detect the mode of action of compounds 9 and 13 in MCF-7 breast adenocarcinoma cells.Compounds 3, 9-13 displayed cytotoxic effects against the four tested cancer cell lines with IC50values below 85 μM. Compounds 9 and 13 had IC50values below 10 μM in 4/4 and 3/4 tested cell lines respectively. The IC50values varied from 0.36 μM (against MCF7 cells) to 5.65 μM (towards colon carcinoma DLD-1 cells) for 9, from 9.78 μM (against MCF7 cells) to 67.68 μM (against HepG2 cells) for 13 and 0.18 μM (towards HepG2 cells) to 72 μM (towards Caco-2 cells) for the reference drug, doxorubicin. Compounds 9 and 13 induced cell cycle arrest in Go/G1 whilst doxorubicin induced arrest in G2/M. The two molecules (9 and 13) also induced apoptosis in MCF-7 cells through activation of caspases 3/7 and 9 as well as enhanced ROS production.
    CONCLUSIONS:
    Compounds 9 and 13 are good cytotoxic phytochemicals that should be explored more in future to develop a cytotoxic drug to fight human carcinoma.
    In vivo:
    Journal of the Korean Society for Applied Biological Chemistry, 2013, 56(5):541–545.
    Antinociceptive effect of glyasperin F isolated from Glycyrrhiza inflata in mice.[Reference: WebLink]
    Antinociceptive effect of glyasperin F isolated from Glycyrrhiza inflata extract (GIE) in ICR mice was studied.
    METHODS AND RESULTS:
    Oral administration of GIE (1–100 mg/kg) caused a dose-dependent reduction in acetic acid-induced writhing responses. To identify the active antinociceptive compound from the GIE, sub-fractions were obtained from the EtOAc layer of GIE by using a medium pressure liquid chromatography. From the sub-fractions obtained, the sub-fraction, which, when administered orally (10 mg/kg) showed an antinociceptive effect in both the writhing test and second phase of the formalin test was identified as glyasperin F using NMR and MS analyses. Finally, the antinociceptive effect of glyasperin F in mouse models of pain was confirmed. Orally administered glyasperin F (0.1–10mg/kg) showed a dose-dependent antinociceptive effect in both the writhing test and second phase of the formalin test.
    CONCLUSIONS:
    Taken together, glyasperin F isolated from the GIE may be used as a leading compound for further studies on pain and as a new drug derived from natural products for pain therapy.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8221 mL 14.1103 mL 28.2207 mL 56.4414 mL 70.5517 mL
    5 mM 0.5644 mL 2.8221 mL 5.6441 mL 11.2883 mL 14.1103 mL
    10 mM 0.2822 mL 1.411 mL 2.8221 mL 5.6441 mL 7.0552 mL
    50 mM 0.0564 mL 0.2822 mL 0.5644 mL 1.1288 mL 1.411 mL
    100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.5644 mL 0.7055 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2',4'-二羟基-7-甲氧基异黄酮; 5-Deoxycajanin CFN97240 7622-53-9 C16H12O5 = 284.3 5mg QQ客服:2159513211
    2',4',5,7-四羟基异黄烷酮; Dalbergioidin CFN97931 30368-42-4 C15H12O6 = 288.3 5mg QQ客服:1413575084
    2'-羟基染料木素; 2'-Hydroxygenistein CFN99257 1156-78-1 C15H10O6 = 286.2 5mg QQ客服:1457312923
    Lupinalbin A; Lupinalbin A CFN80045 98094-87-2 C15H8O6 = 284.03 5mg QQ客服:2056216494
    2-羟基异樱黄素; Barpisoflavone A CFN97861 101691-27-4 C16H12O6 = 300.27 5mg QQ客服:2056216494
    木豆异黄酮; 2',4',5-三羟基-7-甲氧基异黄酮; Cajanin CFN98419 32884-36-9 C16H12O6 = 300.3 5mg QQ客服:1413575084
    高淝任素; Homoferreirin CFN97891 482-01-9 C17H16O6 = 316.3 5mg QQ客服:3257982914
    砂生槐异黄酮 A; Sophoraisoflavone A CFN96513 117204-81-6 C20H16O6 = 352.34 5mg QQ客服:215959384
    甘草异黄烷酮; Licoisoflavanone CFN96544 66067-26-3 C20H18O6 = 354.36 5mg QQ客服:2159513211
    粗毛甘草素F; Glyasperin F CFN94013 145382-61-2 C20H18O6 = 354.35 5mg QQ客服:1413575084

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