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  • 粗毛甘草素C

    Glyasperin C

    粗毛甘草素C
    产品编号 CFN95065
    CAS编号 142474-53-1
    分子式 = 分子量 C21H24O5 = 356.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Glycyrrhiza aspera Pall.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    粗毛甘草素C CFN95065 142474-53-1 1mg QQ客服:2056216494
    粗毛甘草素C CFN95065 142474-53-1 5mg QQ客服:2056216494
    粗毛甘草素C CFN95065 142474-53-1 10mg QQ客服:2056216494
    粗毛甘草素C CFN95065 142474-53-1 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Illinois (USA)
  • Agricultural Research Organization (ARO) (Israel)
  • St. Jude Children Research Hospital (USA)
  • Texas A&M University (USA)
  • Center for protein Engineering (CIP) (Belgium)
  • Sant Gadge Baba Amravati University (India)
  • Amity University (India)
  • FORTH-IMBB (Greece)
  • The University of Newcastle (Australia)
  • University of Sao Paulo (Brazil)
  • Kamphaengphet Rajabhat University (Thailand)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Mendel University in Brno (Czech Republic)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Biol Chem.2021, 297(6):101362.
  • J Ethnopharmacol.2020, 260:112988.
  • Molecules.2018, 23(10):E2638
  • VNU Journal of Science: Med.& Pharm. Sci.2022, 38(2):2588-1132.
  • Anal Bioanal Chem.2020, 412(12):3005-3015.
  • BMC Microbiol.2019, 19(1):78
  • Molecules.2019, 24(23):E4303
  • Biosci Rep.2020, 40(8):BSR20201219.
  • Sci Adv.2018, 4(10)
  • RSC Advances2017, 86
  • Nutrients.2021, 13(1):254.
  • Biochem Biophys Res Commun.2020, 530(1):4-9.
  • J Insect Sci.2020, 20(5):18.
  • Pharmaceutics.2022, 14(3):564.
  • Archives of Biological sciences2022, 00:21-21
  • Oxid Med Cell Longev.2020, 2020:8887251.
  • J Ethnopharmacol.2017, 198:205-213
  • Agronomy2023, 13(6), 1435.
  • Pak J Pharm Sci.2018, 31:311-315
  • J of Applied Biological Chem.2020, 63(2):147-152
  • Molecules.2021, 26(16):4722.
  • Crystals2020, 10(3), 206.
  • Molecules.2017, 22(12)
  • ...
  • 生物活性
    Description: Glyasperin C acts as a partial estrogen antagonist, it shows tyrosinase inhibitory activity (IC (50) = 0.13 +/- 0.01 microg/mL), it could be a promising candidate in the design of skin-whitening agents. Glyasperin C shows potent anti-vancomycin-resistant Enterococci effects (MIC 1.9 × 10-5-4.5 × 10-5 M for E. faecium and E. faecalis).
    Targets: Estrogen receptor | Tyrosinase | Antifection | Progestogen receptor
    In vitro:
    Steroids. 2016 Jan;105:42-9.
    Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities.[Pubmed: 26631549 ]
    Licorice root extracts are often consumed as botanical dietary supplements by menopausal women as a natural alternative to pharmaceutical hormone replacement therapy. In addition to their components liquiritigenin (Liq) and isoliquiritigenin (Iso-Liq), known to have estrogenic activity, licorice root extracts also contain a number of other flavonoids, isoflavonoids, and chalcones.
    METHODS AND RESULTS:
    We have investigated the estrogenic activity of 7 of these components, obtained from an extract of Glycyrrhiza glabra powder, namely Glabridin (L1), Calycosin (L2), Methoxychalcone (L3), Vestitol (L4), Glyasperin C (L5), Glycycoumarin (L6), and Glicoricone (L7), and compared them with Liq, Iso-Liq, and estradiol (E2). All components, including Liq and Iso-Liq, have low binding affinity for estrogen receptors (ERs). Their potency and efficacy in stimulating the expression of estrogen-regulated genes reveal that Liq and Iso-Liq and L2, L3, L4, and L6 are estrogen agonists. Interestingly, L3 and L4 have an efficacy nearly equivalent to E2 but with a potency ca. 10,000-fold less. The other components, L1, L5 and L7, acted as partial estrogen antagonists. All agonist activities were reversed by the antiestrogen, ICI 182,780, or by knockdown of ERα with siRNA, indicating that they are ER dependent. In HepG2 hepatoma cells stably expressing ERα, only Liq, Iso-Liq, and L3 stimulated estrogen-regulated gene expression, and in all cases gene stimulation did not occur in HepG2 cells lacking ERα.
    CONCLUSIONS:
    Collectively, these findings classify the components of licorice root extracts as low potency, mixed ER agonists and antagonists, having a character akin to that of selective estrogen receptor modulators or SERMs.
    Molecules. 2014 Aug 25;19(9):13027-41.
    Structures of new phenolics isolated from licorice, and the effectiveness of licorice phenolics on vancomycin-resistant Enterococci.[Pubmed: 25157467]
    Licorice, which is the underground part of Glycyrrhiza species, has been used widely in Asian and Western countries as a traditional medicine and as a food additive.
    METHODS AND RESULTS:
    Our continuous investigation on the constituents of roots and stolons of Glycyrrhiza uralensis led to the isolation of two new phenolics, in addition to 14 known compounds. Structural studies including spectroscopic and simple chemical derivatizations revealed that both of the new compounds had 2-aryl-3-methylbenzofuran structures. An examination of the effectiveness of licorice phenolics obtained in this study on vancomycin-resistant strains Enterococcus faecium FN-1 and Enterococcus faecalis NCTC12201 revealed that licoricidin showed the most potent antibacterial effects against both of E. faecalis and E. faecium with a minimum inhibitory concentration (MIC) of 1.9 × 10-5 M. 8-(γ,γ-Dimethylallyl)-wighteone, isoangustone A, 3'-(γ,γ-dimethylallyl)-kievitone, glyasperin C, and one of the new 3-methyl-2-phenylbenzofuran named neoglycybenzofuran also showed potent anti-vancomycin-resistant Enterococci effects (MIC 1.9 × 10-5-4.5 × 10-5 M for E. faecium and E. faecalis).
    CONCLUSIONS:
    The HPLC condition for simultaneous detection of the phenolics in the extract was investigated to assess the quality control of the natural antibacterial resource, and quantitative estimation of several major phenolics in the extract with the established HPLC condition was also performed. The results showed individual contents of 0.08%-0.57% w/w of EtOAc extract for the major phenolics in the materials examined.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8058 mL 14.0292 mL 28.0584 mL 56.1167 mL 70.1459 mL
    5 mM 0.5612 mL 2.8058 mL 5.6117 mL 11.2233 mL 14.0292 mL
    10 mM 0.2806 mL 1.4029 mL 2.8058 mL 5.6117 mL 7.0146 mL
    50 mM 0.0561 mL 0.2806 mL 0.5612 mL 1.1223 mL 1.4029 mL
    100 mM 0.0281 mL 0.1403 mL 0.2806 mL 0.5612 mL 0.7015 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    脱氢雌马酚; Phenoxodiol CFN91578 81267-65-4 C15H12O3 = 240.3 5mg QQ客服:1457312923
    去甲基驴食草酚; Demethylvestitol CFN96183 65332-45-8 C15H14O4 = 258.3 5mg QQ客服:1457312923
    驴食草酚; Vestitol CFN98483 35878-41-2 C16H16O4 = 272.3 5mg QQ客服:1457312923
    Isosativan; Isosativan CFN97016 60102-29-6 C17H18O4 = 286.3 5mg QQ客服:215959384
    (-)-Sativan; (-)-Sativan CFN89475 41743-86-6 C17H18O4 = 286.32 5mg QQ客服:3257982914
    Sativan; Sativan CFN96501 71831-00-0 C17H18O4 = 286.32 5mg QQ客服:1457312923
    (R)-Mucronulatol; (R)-Mucronulatol CFN95492 57128-11-7 C17H18O5 = 302.3 10mg QQ客服:2056216494
    Mucronulatol; Mucronulatol CFN95386 20878-98-2 C17H18O5 = 302.3 5mg QQ客服:2159513211
    3',8-二羟基驴食草酚; 3',8-Dihydroxyvestitol CFN95384 122587-87-5 C16H16O6 = 304.3 5mg QQ客服:2056216494
    光甘草定; Glabridin CFN99731 59870-68-7 C20H20O4 = 324.37 20mg QQ客服:215959384

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