萝卜硫苷

Glucoraphanin

	产品编号	CFN93151
	CAS编号	21414-41-5
	分子式 = 分子量	C₁₂H₂₃NO₁₀S₃ = 437.5
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The seeds of Raphanus sativus L.
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产品名称	产品编号	CAS编号	包装	QQ客服
萝卜硫苷	CFN93151	21414-41-5	1mg	QQ客服：215959384
萝卜硫苷	CFN93151	21414-41-5	5mg	QQ客服：215959384
萝卜硫苷	CFN93151	21414-41-5	10mg	QQ客服：215959384
萝卜硫苷	CFN93151	21414-41-5	20mg	QQ客服：215959384

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Description:

Glucoraphanin, the bioprecursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, it has antioxidant activity, it induces phase-I xenobiotic metabolizing enzymes and increases free radical generation in rat liver. Glucoraphanin can ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice. Glucoraphanin and Glucoerucin effectively act as antagonists for the aryl hydrocarbon receptor, and this may contribute to their established chemoprevention potency.

Targets:

Nrf2 | P450 (e.g. CYP17)

In vitro:

Asian Pac J Cancer Prev. 2015;16(14):5801-5.

Naturally-Occurring Glucosinolates, Glucoraphanin and Glucoerucin, are Antagonists to Aryl Hydrocarbon Receptor as Their Chemopreventive Potency.[Pubmed: 26320454]

As a cytosolic transcription factor, the aryl hydrocarbon (Ah) receptor is involved in several patho- physiological events leading to immunosuppression and cancer; hence antagonists of the Ah receptor may possess chemoprevention properties.
METHODS AND RESULTS:
It is known to modulate carcinogen-metabolising enzymes, for instance the CYP1 family of cytochromes P450 and quinone reductase, both important in the biotransformation of many chemical carcinogens via regulating phase I and phase II enzyme systems. Utilising chemically-activated luciferase expression (CALUX) assay it was revealed that intact glucosinolates, glucoraphanin and glucoerucin, isolated from Brassica oleracea L. var. acephala sabellica and Eruca sativa ripe seeds, respectively, are such antagonists. Both glucosinolates were poor ligands for the Ah receptor; however, they effectively antagonised activation of the receptor by the avid ligand benzo[a]pyrene. Indeed, intact glucosinolate glucoraphanin was a more potent antagonist to the receptor than glucoerucin.
CONCLUSIONS:
It can be concluded that both glucosinolates effectively act as antagonists for the Ah receptor, and this may contribute to their established chemoprevention potency.

In vivo:

Diabetes. 2017 May;66(5):1222-1236.

Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice.[Pubmed: 28209760 ]

Low-grade sustained inflammation links obesity to insulin resistance and nonalcoholic fatty liver disease (NAFLD). However, therapeutic approaches to improve systemic energy balance and chronic inflammation in obesity are limited. Pharmacological activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) alleviates obesity and insulin resistance in mice; however, Nrf2 inducers are not clinically available owing to safety concerns.
METHODS AND RESULTS:
Thus, we examined whether dietary Glucoraphanin, a stable precursor of the Nrf2 inducer sulforaphane, ameliorates systemic energy balance, chronic inflammation, insulin resistance, and NAFLD in high-fat diet (HFD)-fed mice. Glucoraphanin supplementation attenuated weight gain, decreased hepatic steatosis, and improved glucose tolerance and insulin sensitivity in HFD-fed wild-type mice but not in HFD-fed Nrf2 knockout mice. Compared with vehicle-treated controls, Glucoraphanin-treated HFD-fed mice had lower plasma lipopolysaccharide levels and decreased relative abundance of the gram-negative bacteria family Desulfovibrionaceae in their gut microbiomes. In HFD-fed mice, Glucoraphanin increased energy expenditure and the protein expression of uncoupling protein 1 (Ucp1) in inguinal and epididymal adipose depots. Additionally, in this group, Glucoraphanin attenuated hepatic lipogenic gene expression, lipid peroxidation, classically activated M1-like macrophage accumulation, and inflammatory signaling pathways.
CONCLUSIONS:
By promoting fat browning, limiting metabolic endotoxemia-related chronic inflammation, and modulating redox stress, Glucoraphanin may mitigate obesity, insulin resistance, and NAFLD.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
白花菜苷; Glucocapparin	CFN00485	15592-33-3	C₈H₁₄KNO₉S₂ = 371.4	5mg	QQ客服：1413575084
金莲葡糖硫苷; Glucotropaeolin	CFN00500	5115-71-9	C₁₄H₁₈KNO₉S₂ = 447.5	5mg	QQ客服：1457312923
白芥子钾盐; Sinalbin potassium salt	CFN00491	16411-05-5	C₁₄H₁₈KNO₁₀S₂ = 463.5	5mg	QQ客服：1413575084
白芥子苷; Sinalbin	CFN00490	20196-67-2	C₃₀H₄₂N₂O₁₅S₂ = 734.8	5mg	QQ客服：3257982914
4-(α-L-鼠李糖基)苄基芥子油苷; Glucomoringin	CFN00496	316165-49-8	C₂₀H₂₈KNO₁₄S₂ = 609.7	5mg	QQ客服：2159513211
芸苔葡糖硫苷; Glucobrassicin	CFN00484	143231-38-3	C₁₆H₁₉KN₂O₉S₂ = 486.6	5mg	QQ客服：3257982914
1-甲氧基-3-吲哚基甲基硫代葡萄糖苷; Neoglucobrassicin	CFN00503	5187-84-8	C₁₇H₂₁KN₂O₁₀S₂ = 516.6	5mg	QQ客服：2159513211
4-羟基吲哚基-3-甲基硫苷; 4-Hydroxyglucobrassicin	CFN00504	83327-20-2	C₁₆H₁₉KN₂O₁₀S₂ = 502.6	5mg	QQ客服：215959384
4-甲氧基吲哚基-3-甲基硫苷; 4-Methoxyglucobrassicin	CFN00505	83327-21-3	C₁₇H₂₁KN₂O₁₀S₂ = 516.6	5mg	QQ客服：3257982914
间甲氧基苄基芥子油苷; Glucolimnanthin	CFN00483	111810-95-8	C₁₅H₂₀KNO₁₀S₂ = 477.6	5mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2857 mL	11.4286 mL	22.8571 mL	45.7143 mL	57.1429 mL
5 mM	0.4571 mL	2.2857 mL	4.5714 mL	9.1429 mL	11.4286 mL
10 mM	0.2286 mL	1.1429 mL	2.2857 mL	4.5714 mL	5.7143 mL
50 mM	0.0457 mL	0.2286 mL	0.4571 mL	0.9143 mL	1.1429 mL
100 mM	0.0229 mL	0.1143 mL	0.2286 mL	0.4571 mL	0.5714 mL

萝卜硫苷

Glucoraphanin

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