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  • 20(S)-人参皂苷Rh2

    20(S)-Ginsenoside Rh2

    20(S)-人参皂苷Rh2
    产品编号 CFN99971
    CAS编号 78214-33-2
    分子式 = 分子量 C36H62O8 = 622.87
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    20(S)-人参皂苷Rh2 CFN99971 78214-33-2 10mg QQ客服:2056216494
    20(S)-人参皂苷Rh2 CFN99971 78214-33-2 20mg QQ客服:2056216494
    20(S)-人参皂苷Rh2 CFN99971 78214-33-2 50mg QQ客服:2056216494
    20(S)-人参皂苷Rh2 CFN99971 78214-33-2 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Auckland (New Zealand)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Universidad Industrial de Santander (Colombia)
  • Osmania University (India)
  • Kazusa DNA Research Institute (Japan)
  • University of Vigo (Spain)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • University of Madras (India)
  • Amity University (India)
  • Mendel University in Brno (Czech Republic)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • University of British Columbia (Canada)
  • University of Ioannina (Greece)
  • The Ohio State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharm Biol.2016, 54(7):1255-62
  • J Health Sci Med Res.2023, 31584.
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • Int. J of Herbal Med.2023, 11(1): 06-14
  • Front Pharmacol.2021, 12:690113.
  • Molecules.2021, 26(18):5665.
  • Plant Direct.2021, 5(4):e00318.
  • Chemistr of plant2016, 2016021195
  • Molecules.2018, 23(7):E1659
  • Molecules.2021, 26(6):1635.
  • Drug Chem Toxicol.2020, 1-14.
  • FEBS Lett.2021, 595(20):2608-2615.
  • Environ Toxicol.2019, 34(12):1354-1362
  • Legume Science2021, 3(4): e101.
  • J Korean Med Obes Res.2023, 23:10-7
  • J Ginseng Res.2020, 44(4):611-618.
  • Drug Des Devel Ther.2023, 17:2461-2479.
  • Evid Based Complement Alternat Med.2021, 2021:5319584.
  • Front Pharmacol.2022, 13:883475.
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • Korean Journal of Pharmacognosy2018, 49(4):349-361
  • Korean Journal of Plant Resources2021, 34(1):52-58.
  • Data Science for Genomics2023, 107-128.
  • ...
  • 生物活性
    Description: Ginsenoside Rh2 has memory-enhancing ,anti-osteoporosis, antitumor, antidiabetic, antiallergic, and anti-inflammatory effects, it potently protects ischemia-reperfusion brain injury, also inhibits prostaglandin-E_2 synthesis in lipopolysaccharide-stimulated RAW264.7 cells. It can inhibit the tendency of apoptosis, and reverse the impaired β-cell growth potential by modulating Akt/Foxo1/PDX-1 signaling pathway and regulating cell cycle proteins; it suppresses RANKL-induced osteoclast differentiation in vitro and in vivo through the regulation of c-Fos and NFATc1 expressions, not excluding the involvement of NF-κB and ERK.
    Targets: HDAC | CDK | p21 | Caspase | MMP(e.g.TIMP) | P-gp | P450 (e.g. CYP17) | c-Fos | NFATc1 | PGE2 | Aldose reductase
    In vitro:
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Oct;30(10):1062-6.
    [Regulatory effect of ginsenoside Rh2 on HDAC1/2 activity and cyclin in human erythroleukemia K562 cells].[Pubmed: 25270209]
    To investigate the effects of the 20(S)-Ginsenoside Rh2 [Rh2(S)]on cell proliferation, histone deacetylase 1 (HDAC1) and HDAC2 activity, and expression of cyclin in human erythroleukemia K562 cells.
    METHODS AND RESULTS:
    The proliferation of K562 cells was inhibited by 20(S)-Ginsenoside Rh2 (20-80 μmol/L) in dose-and time-dependent manner. FCM analyses revealed that the number of the K562 cells treated with 60 μmol/L 20(S)-Ginsenoside Rh2 was arrested in G0/G1 phase. The apoptosis rates of K562 cells were respectively (8.09±0.86)%, (9.44±0.53)% and (22.80±2.16)% after induced by 20, 40, 60 μmol/L 20(S)-Ginsenoside Rh2, which showed statistically significant difference (P<0.05) compared with the control group (2.63±0.14)%. HDAC activity of the cells treated with 20(S)-Ginsenoside Rh2 (40, 60 μmol/L) was reduced. Western blotting showed that the expressions of HDAC1, HDAC2, cyclin D1 and CDK4 decreased after induced by 20(S)-Ginsenoside Rh2, and p16INK4A, p21 proteins were enhanced significantly.
    CONCLUSIONS:
    The 20(S)-Ginsenoside Rh2 can inhibit the proliferation of K562 cells and induce its cycle arrest and apoptosis through inhibiting HDAC1 and HDAC2 activity, down-regulating the expression of cyclin D1 and activating p16INK4A and p21.
    Biol Pharm Bull. 2014;37(2):248-54.
    20S-Ginsenoside Rh2 induces apoptosis in human Leukaemia Reh cells through mitochondrial signaling pathways.[Pubmed: 24492721]
    20(S)-Ginsenoside Rh2 (GRh2) and ginsenoside Rg3 (GRg3) are members of the protopanaxadiol family and have been investigated for possible chemopreventive activity. This study explored the biological and apoptotic mechanisms induced by 20(S)-GRh2 in human acute leukaemia line-Reh cells.
    METHODS AND RESULTS:
    Reh cells were treated with different concentration of 20(S)-Ginsenoside Rh2 in vitro. Cell viability was determined by Cell Counting Kit-8 and Annexin V/7-AAD assays. Mitochondrial membrane potential (MMP) was examined through JC-1 staining. Activation of caspases associated with the mitochondria-mediated apoptosis pathway was determined by Western blot. We observed that survival of Reh cells decreased after exposure to 20(S)-Ginsenoside Rh2 in a concentration-dependent manner. Moreover,20(S)-Ginsenoside Rh2 can induce mitochondria depolarization of Reh cells as evident in the shift in JC-1 fluorescence from red to green. In addition, 20(S)-Ginsenoside Rh2 induced the release of mitochondrial cytochrome c and activation of caspase-9 and caspase-3 in Reh cells.
    CONCLUSIONS:
    These results indicate that 20(S)-Ginsenoside Rh2 could induce apoptosis through the mitochondrial pathway, demonstrating its potential as a chemotherapeutic agent for leukaemia therapy.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6055 mL 8.0274 mL 16.0547 mL 32.1094 mL 40.1368 mL
    5 mM 0.3211 mL 1.6055 mL 3.2109 mL 6.4219 mL 8.0274 mL
    10 mM 0.1605 mL 0.8027 mL 1.6055 mL 3.2109 mL 4.0137 mL
    50 mM 0.0321 mL 0.1605 mL 0.3211 mL 0.6422 mL 0.8027 mL
    100 mM 0.0161 mL 0.0803 mL 0.1605 mL 0.3211 mL 0.4014 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (20R)-原人参二醇; (20R)-Protopanaxdiol CFN99979 7755-01-3 C30H52O3 = 460.74 20mg QQ客服:1413575084
    20(S)-原人参二醇; (20S)-Protopanaxdiol CFN99764 30636-90-9 C30H52O3 = 460.00 20mg QQ客服:3257982914
    20(S)-人参皂苷Rh2; 20(S)-Ginsenoside Rh2 CFN99971 78214-33-2 C36H62O8 = 622.87 20mg QQ客服:1457312923
    20(R)-人参皂苷Rh2; 20(R)-Ginsenoside Rh2 CFN90340 112246-15-8 C36H62O8 = 622.88 20mg QQ客服:2056216494
    人参皂苷Rg3; Ginsenoside Rg3 CFN99969 14197-60-5 C42H72O13 = 785.02 20mg QQ客服:2159513211
    20(R)-人参皂苷Rg3; 20(R)-Ginsenoside Rg3 CFN98170 38243-03-7 C42H72O13 = 785.02 20mg QQ客服:2159513211
    人参皂苷Rs3; Ginsenoside Rs3 CFN92813 194861-70-6 C44H74O14 = 827.1 5mg QQ客服:1457312923
    三七皂苷Ft1; Notoginsenoside Ft1 CFN90859 155683-00-4 C47H80O17 = 917.2 20mg QQ客服:2159513211
    绞股蓝皂苷LI; Gypenoside LI CFN91853 94987-10-7 C42H72O14 = 801.0 5mg QQ客服:1457312923
    绞股蓝皂苷L; Gypenoside L CFN91854 94987-09-4 C42H72O14 = 801.0 5mg QQ客服:215959384

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