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  • 银杏酸C15:1

    Ginkgolic acid C15:1

    银杏酸C15:1
    产品编号 CFN90161
    CAS编号 22910-60-7
    分子式 = 分子量 C22H34O3 = 346.50
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The leaves of Ginkgo biloba L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    银杏酸C15:1 CFN90161 22910-60-7 10mg QQ客服:215959384
    银杏酸C15:1 CFN90161 22910-60-7 20mg QQ客服:215959384
    银杏酸C15:1 CFN90161 22910-60-7 50mg QQ客服:215959384
    银杏酸C15:1 CFN90161 22910-60-7 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Nicolaus Copernicus Uniwersity (Poland)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Charles University in Prague (Czech Republic)
  • University of Ioannina (Greece)
  • University of Wollongong (Australia)
  • Lodz University of Technology (Poland)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Macau University of Science and Technology (China)
  • Worcester Polytechnic Institute (USA)
  • Wageningen University (Netherlands)
  • Korea Institute of Oriental Medicine (Korea)
  • University of Toronto (Canada)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Appl. Sci. 2021, 11(8),3437.
  • Food Research2021, 5(1):65-71
  • BMC Plant Biol.2021, 21(1):60.
  • J Integr Plant Biol.2023, 13564.
  • Oxid Med Cell Longev.2022, 2022:5888636.
  • Life Sci.2019, 216:259-270
  • Cancers (Basel).2023, 15(1):293.
  • Molecules.2020, 25(3):734
  • Plant Cell, Tissue and Organ Culture (PCTOC)2020, 143, 45-60(2020)
  • Cells.2022, 11(8), 1311.
  • Biomolecules.2020, 10(2):E184
  • Antioxidants (Basel).2020, 9(7):581.
  • Cancer Lett. 2023, 18:216584.
  • Planta Med.2022, a-1876-3009.
  • J Sep Sci.2022, 45(18):3556-3566.
  • J Biochem Mol Toxicol.2017, 31(9)
  • Asian Pac J Cancer Prev. 2020, 21(4):935-941.
  • Front Pharmacol.2022, 13:906763.
  • Neurotoxicology.2022, 91:218-227.
  • J Ethnopharmacol.2017, 197:157-164
  • Biomolecules.2020, 10(6):925.
  • Biomed Pharmacother.2023, 163:114785.
  • Exp Parasitol.2018, 194:67-78
  • ...
  • 生物活性
    Description: Ginkgolic acid C15:1 has antibacterial, antiparasitic, and anti-cancer activities, it can suppress lung cancer invasion and migration through the inhibition of PI3K/Akt/mTOR signaling pathway.
    Targets: PI3K | Akt | mTOR | TGF-β/Smad | Antifection
    In vitro:
    Int J Food Microbiol. 2014 Mar 17;174:47-55.
    Ginkgolic acids and Ginkgo biloba extract inhibit Escherichia coli O157:H7 and Staphylococcus aureus biofilm formation.[Pubmed: 24457153]
    Infection by enterohemorrhagic Escherichia coli O157:H7 (EHEC) is a worldwide problem, and there is no effective therapy. Biofilm formation is closely related to EHEC infection and is also a mechanism of antimicrobial resistance.
    METHODS AND RESULTS:
    Antibiofilm screening of 560 purified phytochemicals against EHEC showed that Ginkgolic acid C15:1 and ginkgolic acid C17:1 at 5μg/ml and Ginkgo biloba extract at 100μg/ml significantly inhibited EHEC biofilm formation on the surfaces of polystyrene and glass, and on nylon membranes. Importantly, at their working concentrations, ginkgolic acids and G. biloba extract did not affect bacterial growth. Transcriptional analyses showed that Ginkgolic acid C15:1 repressed curli genes and prophage genes in EHEC, and these findings were in-line with reduced fimbriae production and biofilm reductions. Interestingly, ginkgolic acids and G. biloba extract did not inhibit the biofilm formation of a commensal E. coli K-12 strain. In addition, ginkgolic acids and G. biloba extract inhibited the biofilm formation of three Staphylococcus aureus strains.
    CONCLUSIONS:
    The findings of this study suggest that plant secondary metabolites represent an important resource for biofilm inhibitors.
    BMC Biotechnol. 2017; 17: 5.
    The antibacterial activity and mechanism of ginkgolic acid C15:1.[Pubmed: 28088196]
    The present study investigated the antibacterial activity and underlying mechanisms of Ginkgolic acid C15:1(GA (C15:1)) monomer using green fluorescent protein (GFP)-labeled bacteria strains.
    METHODS AND RESULTS:
    GA presented significant antibacterial activity against Gram-positive bacteria but generally did not affect the growth of Gram-negative bacteria. The studies of the antibacterial mechanism indicated that large amounts of GA (C15:1) could penetrate GFP-labeled Bacillus amyloliquefaciens in a short period of time, and as a result, led to the quenching of GFP in bacteria. In vitro results demonstrated that GA (C15:1) could inhibit the activity of multiple proteins including DNA polymerase. In vivo results showed that GA (C15:1) could significantly inhibit the biosynthesis of DNA, RNA and B. amyloliquefaciens proteins.
    CONCLUSIONS:
    We speculated that GA (C15:1) achieved its antibacterial effect through inhibiting the protein activity of B. amyloliquefaciens. GA (C15:1) could not penetrate Gram-negative bacteria in large amounts, and the lipid soluble components in the bacterial cell wall could intercept GA (C15:1), which was one of the primary reasons that GA (C15:1) did not have a significant antibacterial effect on Gram-negative bacteria.
    Toxicol Appl Pharmacol . 2018 Apr 15;345:1-9.
    Pharmacological inhibition of SUMO-1 with ginkgolic acid alleviates cardiac fibrosis induced by myocardial infarction in mice[Pubmed: 29524504]
    Abstract Background and purpose: Protein modification by small ubiquitin-like modifier (SUMO) plays a critical role in the pathogenesis of heart diseases. The present study was designed to determine whether ginkgolic acid (GA) as a SUMO-1 inhibitor exerts an inhibitory effect on cardiac fibrosis induced by myocardial infarction (MI). Experimental approach: GA was delivered by osmotic pumps in MI mice. Masson staining, electron microscopy (EM) and echocardiography were used to assess cardiac fibrosis, ultrastructure and function. Expression of SUMO-1, PML, TGF-β1 and Pin1 was measured with Western blot or Real-time PCR. Collagen content, cell viability and myofibroblast transformation were measured in neonatal mouse cardiac fibroblasts (NMCFs). Promyelocytic leukemia (PML) protein was over-expressed by plasmid transfection. Key results: GA improved cardiac fibrosis and dysfunction, and decreased SUMO-1 expression in MI mice. GA (>20 μM) inhibited NMCF viability in a dose-dependent manner. Nontoxic GA (10 μM) restrained angiotensin II (Ang II)-induced myofibroblast transformation and collagen production. GA also inhibited expression of TGF-β1 mRNA and protein in vitro and in vivo. GA suppressed PML SUMOylation and PML nuclear body (PML-NB) organization, and disrupted expression and recruitment of Pin1 (a positive regulator of TGF-β1 mRNA), whereas over-expression of PML reversed that. Conclusions and implications: Inhibition of SUMO-1 by GA alleviated MI-induced heart dysfunction and fibrosis, and the SUMOylated PML/Pin1/TGF-β1 pathway is crucial for GA-inhibited cardiac fibrosis.
    In vivo:
    Aquaculture, 2009, 297(1-4):38-43.
    In vivo assessment of anthelmintic efficacy of ginkgolic acids (C13:0, C15:1) on removal of Pseudodactylogyrus in European eel.[Reference: WebLink]
    Pseudodactylogyrus is a significant monogenean parasite of the gills of aquacultured European eels, and can cause severe gill pathology.
    METHODS AND RESULTS:
    In this study, effects of the crude extracts, fractions and compounds of exopleura of Ginkgo biloba against Pseudodactylogyrus were investigated under in vivo conditions by bio-assay guided isolation method. Four solvents (petroleum ether, ethyl acetate, n-butanol and water) were applied for the extraction of exopleura of G. biloba. Among them, only the petroleum ether extract showed strong activity and therefore, subjected to further separation and purification using various chromatographic techniques. Two compounds showing potent activity were identified by comparing spectral data (IR, NMR, and EI-MS) with literature values to be ginkgolic acid C13:0 and Ginkgolic acid C15:1. They were found to be 100% effective at the concentration of 2.5mg l⁻1 and 6.0mg l⁻1, with ED₅₀ values of 0.72mg l⁻1 and 2.88mg l⁻1, respectively. In the 5-days safety test, ginkgolic acid C13:0 and Ginkgolic acid C15:1 were shown to be safe for healthy juvenile eels when the concentration were up to 10.0 and 18.0mg l⁻1, respectively.
    CONCLUSIONS:
    The two compounds exhibited potential results and can be explored as plant-derived antiparasitic for the control of Pseudodactylogyrus.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.886 mL 14.43 mL 28.86 mL 57.7201 mL 72.1501 mL
    5 mM 0.5772 mL 2.886 mL 5.772 mL 11.544 mL 14.43 mL
    10 mM 0.2886 mL 1.443 mL 2.886 mL 5.772 mL 7.215 mL
    50 mM 0.0577 mL 0.2886 mL 0.5772 mL 1.1544 mL 1.443 mL
    100 mM 0.0289 mL 0.1443 mL 0.2886 mL 0.5772 mL 0.7215 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    银杏酸C15:0; Ginkgolic acid C15:0 CFN90339 16611-84-0 C22H36O3 = 348.52 5mg QQ客服:1413575084
    银杏酸C15:1; Ginkgolic acid C15:1 CFN90161 22910-60-7 C22H34O3 = 346.50 20mg QQ客服:3257982914
    银杏酸C17:1; Ginkgolic acid C17:1 CFN98508 111047-30-4 C24H38O3 = 374.56 20mg QQ客服:1457312923
    Pelandjauic acid; Pelandjauic acid CFN92849 141545-69-9 C24H36O3 = 372.3 5mg QQ客服:1413575084
    毛色二孢素; Lasiodiplodin CFN97898 32885-81-7 C17H24O4 = 292.4 5mg QQ客服:1413575084
    玉米烯酮; Zearalenone CFN91172 17924-92-4 C18H22O5 = 318.4 20mg QQ客服:1457312923
    3-香叶草基-4-甲氧基苯甲酸; 3-Geranyl-4-methoxybenzoic acid CFN98266 246266-38-6 C18H24O3 = 288.4 5mg QQ客服:1413575084
    灰叶酸; Grifolic acid CFN97284 80557-12-6 C23H32O4 = 372.5 5mg QQ客服:1457312923
    Cytosporone B; Cytosporone B CFN90885 321661-62-5 C18H26O5 = 322.4 10mg QQ客服:215959384
    2'-O-甲基配列地衣酸; 2'-O-Methylperlatolic acid CFN98621 38968-07-9 C26H34O7 = 458.6 5mg QQ客服:1413575084

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