Germanicol acetate

	产品编号	CFN96961
	CAS编号	10483-91-7
	分子式 = 分子量	C₃₂H₅₂O₂ = 468.76
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The latex of Euphorbia umbellata (Pax) Bruyns.
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产品名称	产品编号	CAS编号	包装	QQ客服
Germanicol acetate	CFN96961	10483-91-7	1mg	QQ客服：3257982914
Germanicol acetate	CFN96961	10483-91-7	5mg	QQ客服：3257982914
Germanicol acetate	CFN96961	10483-91-7	10mg	QQ客服：3257982914
Germanicol acetate	CFN96961	10483-91-7	20mg	QQ客服：3257982914

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Description:

Germanicol acetate shows some slight cytotoxic activity against Jurkat cells .

In vitro:

J Ethnopharmacol. 2016 May 13;183:29-37.

Cytotoxic biomonitored study of Euphorbia umbellata (Pax) Bruyns.[Pubmed: 26906968 ]

Euphorbia umbellata latex (sap) has normally been used in folk medicine in southern Brazil to treat different types of cancers. To carry out a biomonitored investigation of partitioned latex using in vitro assay, to identify the main mechanisms related with the action of the most active fraction as well as to develop a phytochemical study with this material.
METHODS AND RESULTS:
Biological screening was performed with hexane, chloroform, ethyl acetate and methanol fractions from the latex of E. umbellata using MTT, trypan blue, and neutral red assays to determine the cytotoxicity against HRT-18, HeLa and Jurkat cells and flow cytometry, DNA quantification, acridine orange and Hoechst 33342 staining to investigate mechanisms of action for the hexane extract. The phytochemical study of the hexane fraction was performed by chromatographic procedures and the substances were identified by NMR analysis. The isolated terpenes were evaluated using MTT to determine the cytotoxicity against Jurkat cells. All the fractions presented concentration and time dependent cytotoxicity. The hexane fraction showed the highest cytotoxicity; whereas the Jurkat cell was the lineage with the highest sensitivity (IC50 1.87µg/mL). Fragmentation of DNA and apoptosis are two mechanisms related with the toxicity of hexane fraction. The hexane fraction arrested the cell cycle in the G0/G1 phase, and the selectivity index was 4.30. Phytochemical study of the hexane fraction led to isolation of euphol (main compound) and germanicol acetate. Both substances demonstrated some slight cytotoxic activity against Jurkat cells after 72h; however the activity was minimal compared to vincristine (anticancer standard drug).
CONCLUSIONS:
The current research proves that the fractions of the latex from E. umbellata have a cytotoxic effect against three different cancer cells lines. The hexane fraction showed high in vitro cytotoxic effects against Jurkat cells demonstrating that the effect may be due to non-polar constituents. The two isolated terpenes (euphol and germanicol acetate) showed poor cytotoxic activity indicating that the anticancer properties of the extract may be caused by other substances present in the hexane fraction.

In vivo:

Saudi Pharm J. 2014 Nov;22(5):460-71.

Phytochemical and pharmacological study of Ficus palmata growing in Saudi Arabia.[Pubmed: 25473335 ]

Phytochemical study of the aerial parts of Ficus palmata utilizing liquid-liquid fractionation and different chromatographic techniques resulted in the isolation of a new isomer of psoralenoside namely, trans-psoralenoside (5) in addition to, one triterpene: Germanicol acetate (1), two furanocoumarins: psoralene (2), bergapten (3), one aromatic acid vanillic acid (4) and the flavone glycoside rutin (6).
METHODS AND RESULTS:
Structures of the isolated compounds were established through physical, 1D- and 2D-NMR and MS data. The total extract and fractions of the plant were examined in vivo for its possible effects as hepatoprotective, nephroprotective, antiulcer and anticoagulant activities in comparison with standard drugs. Hepatoprotective activity was assessed via serum biochemical parameters including aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT), alkaline phosphatase (ALP) and total bilirubin. Tissue parameters such as non-protein sulfhydryl groups (NP-SH), malonaldehyde (MDA) and total protein (TP) were also measured. In addition to tissue parameters, nephroprotective effect was evaluated by measuring the serum levels of sodium, potassium, creatinine and urea. Histopathological study for both liver and kidney cells was also conducted. Antiulcer activity was explored by observing stomach lesions after treatment with ethanol. Whole blood clotting time (CT) was taken as a measure for the anticoagulant activity of the extract. Antioxidant activity of the total extract and fractions of the plant was measured using 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and ascorbic acid as standard.

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黑果茜草萜 B ; Rubiprasin B	CFN96835	125263-66-3	C₃₂H₅₂O₄ = 500.76	5mg	QQ客服：1457312923
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13(18)-齐墩果烯-3-醇，Α-香树素; 13(18)-Oleanen-3-ol	CFN98801	508-04-3	C₃₀H₅₀O = 426.7	5mg	QQ客服：215959384
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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1333 mL	10.6664 mL	21.3329 mL	42.6658 mL	53.3322 mL
5 mM	0.4267 mL	2.1333 mL	4.2666 mL	8.5332 mL	10.6664 mL
10 mM	0.2133 mL	1.0666 mL	2.1333 mL	4.2666 mL	5.3332 mL
50 mM	0.0427 mL	0.2133 mL	0.4267 mL	0.8533 mL	1.0666 mL
100 mM	0.0213 mL	0.1067 mL	0.2133 mL	0.4267 mL	0.5333 mL

Germanicol acetate

Germanicol acetate

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