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  • 没食子儿茶素没食子酸酯

    (-)-Gallocatechin gallate

    没食子儿茶素没食子酸酯
    产品编号 CFN99571
    CAS编号 4233-96-9
    分子式 = 分子量 C22H18O11 = 458.37
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Flavonoids
    植物来源 The woods of Acacia catechu (L.F.) Willd.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    没食子儿茶素没食子酸酯 CFN99571 4233-96-9 10mg QQ客服:2056216494
    没食子儿茶素没食子酸酯 CFN99571 4233-96-9 20mg QQ客服:2056216494
    没食子儿茶素没食子酸酯 CFN99571 4233-96-9 50mg QQ客服:2056216494
    没食子儿茶素没食子酸酯 CFN99571 4233-96-9 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • FORTH-IMBB (Greece)
  • University of Wuerzburg (Germany)
  • Universidade Católica Portuguesa (Portugal)
  • University of Indonesia (Indonesia)
  • Weizmann Institute of Science (Israel)
  • Chinese University of Hong Kong (China)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • University of Ioannina (Greece)
  • Massachusetts General Hospital (USA)
  • Center for protein Engineering (CIP) (Belgium)
  • University of Oslo (Norway)
  • University of Padjajaran (Indonesia)
  • University of Maryland School of Medicine (USA)
  • National Hellenic Research Foundation (Greece)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Indian J Pharm Sci.2022, 84(4): 874-882.
  • Antioxidants (Basel).2022, 11(10):1929.
  • Cells.2022, 11(8), 1311.
  • J Chromatogr Sci.2020, 58(6):485-493.
  • Microb Pathog.2019, 131:128-134
  • Evid-Based Compl Alt2020, 7202519:13
  • Mol Neurobiol.2021, 58(8):3665-3676.
  • Plant Sci.2021, 313:111069.
  • Biomed Pharmacother.2020, 128:110318.
  • Korean J. of Horticultural Sci. & Tech. 2017, 793-804
  • Molecules 2022, 27(3),1047.
  • Plant Biotechnology Reports 2021, 15:117-124.
  • Appl. Sci.2020, 10(8),2804
  • Mediators Inflamm.2016, 2016:7216912
  • J Food Sci.2022, 87(11):4905-4916.
  • Microchemical Journal2024: 196:109676.
  • Evid Based Complement Alternat Med.2016, 2016:1230294
  • Anal Bioanal Chem.2023, 415(9):1641-1655.
  • Evid Based Complement Alternat Med.2020, 2020:2584783.
  • Institut Pasteur Korea2020, doi: 10.21203.
  • Plant Physiol Biochem.2023, 203:108073.
  • Biomedicines.2021, 9(8):996.
  • Natural Product Communications2020, doi: 10.1177.
  • ...
  • 生物活性
    Description: (-)-Gallocatechin gallate has cancer-preventive activities, it can precipitate cholesterol, decreasee osteoclastogenesis at 20 microM.
    Targets: NF-κB | mRNA
    In vitro:
    J Agric Food Chem. 2009 Aug 26;57(16):7293-7.
    Effects of tea catechins, epigallocatechin, gallocatechin, and gallocatechin gallate, on bone metabolism.[Pubmed: 19653629 ]

    METHODS AND RESULTS:
    In this study, three tea catechins, epigallocatechin (EGC), gallocatechin (GC), and (-)-Gallocatechin gallate (GCG), were investigated for their effects on bone metabolism. The effects of the tea catechins on bone formation were evaluated using cultured rat osteoblast-like osteosarcoma cell line UMR-106. EGC stimulated alkaline phosphatase activity significantly at concentrations of 10 and 20 microM. The amount of mineralization also increased significantly with EGC. On another cell culture platform, EGC significantly inhibited osteoclast formations from RAW 264.7 cells upon receptor activation of nuclear factor-kappaB ligand induction on the fourth day of treatment, at a concentration of 10 microM. EGC also dose-dependently inhibited the mRNA expression of tatrate-resistant acid phosphatase. GC and GCG could decrease osteoclastogenesis at 20 microM.
    CONCLUSIONS:
    The present study illustrated that the tea catechins, EGC in particular, had positive effects on bone metabolism through a double process of promoting osteoblastic activity and inhibiting osteoclast differentiations.
    J Agric Food Chem. 2003 Dec 3;51(25):7303-7.
    Heat-epimerized tea catechins rich in gallocatechin gallate and catechin gallate are more effective to inhibit cholesterol absorption than tea catechins rich in epigallocatechin gallate and epicatechin gallate.[Pubmed: 14640575]
    It has been known that tea catechins, (-)-epicatechin (1), (-)-epigallocatechin (2), (-)-epicatechin gallate (3), and (-)-epigallocatechin gallate (4) are epimerized to(-)-catechin (5), (-)-gallocatechin (6), (-)-catechin gallate (7), and (-)-Gallocatechin gallate (8), respectively, during retort pasteurization. We previously reported that tea catechins, mainly composed of 3 and 4, effectively inhibit cholesterol absorption in rats.
    METHODS AND RESULTS:
    In this study, the effect of heat-epimerized catechins on cholesterol absorption was compared with tea catechins. Both tea catechins and heat-epimerized catechins lowered lymphatic recovery of cholesterol in rats cannulated in the thoracic duct and epimerized catechins were more effective than tea catechins. The effect of purified catechins on micellar solubility of cholesterol was examined in an in vitro study. The addition of gallate esters of catechins reduced micellar solubility of cholesterol by precipitating cholesterol from bile salt micelles. Compounds 7 and 8 were more effective to precipitate cholesterol than 3 and 4, respectively.
    CONCLUSIONS:
    These observations strongly suggest that heat-epimerized catechins may be more hypocholesterolemic than tea catechins.
    Food Chem . 2017 Nov 15;235:227-233.
    C-geranylated flavanones from YingDe black tea and their antioxidant and α-glucosidase inhibition activities[Pubmed: 28554631]
    Abstract YingDe black tea is produced from crude tea prepared from leaves of Camellia sinensis var. assamica. In this work, we isolated and identified five novel flavanones, namely, amelliaone A-E (1-5), along with seven known compounds 6-12 from the ethanol extract of YingDe black tea. The structures of these five novel phenolic compounds were determined using extensive 1D and 2D nuclear magnetic resonance spectroscopy experiments. The compounds were further evaluated for antioxidant, α-glucosidase inhibitory, and cytotoxic activities. Compound 1 exhibited higher α-glucosidase inhibitory activity with a half-maximum inhibitory concentration value (IC50) of 10.2μM compared with acarbose (18.2μM). Keywords: (−)-Epicatechin (PubChem CID: 72276); (−)-Gallocatechin gallate (PubChem CID: 199472); Amentoflavone (PubChem CID: 5281600); Apigenin (PubChem CID: 5280443); Camellia var. assamica; Epigallocatechin gallate (PubChem CID: 65064); Flavanone; Gallic acid (PubChem CID: 370); Quercetin (PubChem CID: 5280343); YingDe black tea; α-Glucosidase inhibitory activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1816 mL 10.9082 mL 21.8164 mL 43.6329 mL 54.5411 mL
    5 mM 0.4363 mL 2.1816 mL 4.3633 mL 8.7266 mL 10.9082 mL
    10 mM 0.2182 mL 1.0908 mL 2.1816 mL 4.3633 mL 5.4541 mL
    50 mM 0.0436 mL 0.2182 mL 0.4363 mL 0.8727 mL 1.0908 mL
    100 mM 0.0218 mL 0.1091 mL 0.2182 mL 0.4363 mL 0.5454 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (+)-儿茶素 5-没食子酸酯; (+)-atechin 5-gallate CFN70264 128232-62-2 C22H18O10 = 442.4 5mg QQ客服:2159513211
    (-)-没食子酸儿茶素酯;儿茶素没食子酸酯; (-)-Catechin gallate(CG) CFN98504 130405-40-2 C22H18O10 = 442.37 20mg QQ客服:215959384
    (-)-棓儿茶酸; 没食子儿茶素; (-)-Gallocatechin CFN99137 3371-27-5 C15H14O7 = 306.27 20mg QQ客服:1413575084
    没食子儿茶素没食子酸酯; (-)-Gallocatechin gallate CFN99571 4233-96-9 C22H18O11 = 458.37 20mg QQ客服:3257982914
    没食子儿茶素没食子酸酯; Gallocatechin gallate CFN96488 5127-64-0 C22H18O11 = 458.37 5mg QQ客服:2056216494

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