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  • 补骨脂香豆素A

    Ficusin A

    补骨脂香豆素A
    产品编号 CFN99817
    CAS编号 173429-83-9
    分子式 = 分子量 C25H24O5 = 404.5
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The seeds of Psoralea corylifolia Linn.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    补骨脂香豆素A CFN99817 173429-83-9 1mg QQ客服:1457312923
    补骨脂香豆素A CFN99817 173429-83-9 5mg QQ客服:1457312923
    补骨脂香豆素A CFN99817 173429-83-9 10mg QQ客服:1457312923
    补骨脂香豆素A CFN99817 173429-83-9 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • St. Jude Children Research Hospital (USA)
  • Sant Gadge Baba Amravati University (India)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • University of Medicine and Pharmacy (Romania)
  • Universidad de Buenos Aires (Argentina)
  • Korea Food Research Institute(KFRI) (Korea)
  • Max-Planck-Insitut (Germany)
  • Univerzita Karlova v Praze (Czech Republic)
  • Universidad Veracuzana (Mexico)
  • Universidad de Antioquia (Colombia)
  • University of Wollongong (Australia)
  • Massachusetts General Hospital (USA)
  • University of Canterbury (New Zealand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Braz J Med Biol Res. 2016, 49(7)
  • Ind Crops Prod.2014, 62:173-178
  • Phytomedicine.2017, 24:77-86
  • Appl. Sci.2020, 10(16),5482.
  • Molecules.2018, 23(7):E1817
  • JMSACL2023, 09.002
  • Food Sci Biotechnol.2021, 30(2):217-226.
  • Nutrients.2019, 11(11):E2694
  • J Pharm Biomed Anal2016, 118:183-194
  • Turk J Med Sci.2023 53: 1312-1320.
  • J Nat Med.2021, doi: 10.1007.
  • Natural Product Communications2023, 18(9).
  • J Anal Toxicol.2021, bkab015.
  • Nutraceuticals2022, 2(3),150-161
  • Sci Rep.2023, 13(1):7475.
  • Environ Toxicol.2020, doi: 10.1002
  • Indian J Pharm Sci.2022, 84(3):144-151
  • J of Dentistry & Oral Health2019, 2641-1962
  • Food Res Int.2022, 157:111207.
  • Biol Pharm Bull.2017, 40(6):797-806
  • Int J Mol Sci.2021, 22(19):10220.
  • Int J Mol Sci.2019, 20(3):E651
  • Industrial Crops and Products2017, 95:286-295
  • ...
  • 生物活性
    Description: Ficusin has antioxidant, antilipidemic and antidiabetic effects, it can lower the levels of fasting blood glucose, plasma insulin, body weight gain in HFD-STZ induced diabetic rats, and can significantly enhance the PPARγ expression and improve the translocation and activation of GLUT4 in the adipose tissue, suggests that ficusin improves the insulin sensitivity on adipose tissue and it can be used for the treatment of obesity related type 2 diabetes mellitusl.
    Targets: GLUT | PPAR
    In vivo:
    Chem. Biol. Interact.,2016,256:85-93.
    Antioxidant, antilipidemic and antidiabetic effects of ficusin with their effects on GLUT4 translocation and PPARγ expression in type 2 diabetic rats.[Reference: WebLink]
    In this study, the antioxidant, antilipidemic and antidiabetic effects of ficusin isolated from Ficus carica leaves and their effects on GLUT4 translocation and PPARγ expression were evaluated in HFD-STZ induced type 2 diabetic rats.
    METHODS AND RESULTS:
    Ficusin (20 and 40 mg/kg b. wt.) lowered the levels of fasting blood glucose, plasma insulin and body weight gain, in HFD-STZ induced diabetic rats. Ficusin Also significantly lowered the serum antioxidant enzymes (SOD, CAT and GPx) and lipids (TC, TG and FFA) levels to near normal. Ficusin significantly enhanced the PPARγ expression and improved the translocation and activation of GLUT4 in the adipose tissue. Molecular docking analysis exhibited promising interactions of GLUT4 and PPARγ into their active sites.
    CONCLUSIONS:
    This study suggests that ficusin improved the insulin sensitivity on adipose tissue and it can be used for the treatment of obesity related type 2 diabetes mellitus.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4722 mL 12.3609 mL 24.7219 mL 49.4438 mL 61.8047 mL
    5 mM 0.4944 mL 2.4722 mL 4.9444 mL 9.8888 mL 12.3609 mL
    10 mM 0.2472 mL 1.2361 mL 2.4722 mL 4.9444 mL 6.1805 mL
    50 mM 0.0494 mL 0.2472 mL 0.4944 mL 0.9889 mL 1.2361 mL
    100 mM 0.0247 mL 0.1236 mL 0.2472 mL 0.4944 mL 0.618 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    8-异戊烯基大豆苷元; 8-Prenyldaidzein CFN97827 135384-00-8 C20H18O4 = 322.36 5mg QQ客服:1413575084
    黄羽扇豆魏特酮; Lupiwighteone CFN96146 104691-86-3 C20H18O5 = 338.4 5mg QQ客服:215959384
    Derrone; Derrone CFN97689 76166-59-1 C20H16O5 = 336.34 5mg QQ客服:2159513211
    甘草宁M; Gancaonin M CFN97883 129145-51-3 C21H20O5 = 352.4 5mg QQ客服:1457312923
    2,3-脱氢维酮; 2,3-Dehydrokievitone CFN97223 74161-25-4 C20H18O6 = 354.4 5mg QQ客服:1457312923
    灰毛豆黄素; Toxicarolisoflavone CFN96208 3044-60-8 C23H22O7 = 410.4 5mg QQ客服:215959384
    补骨脂香豆素A; Ficusin A CFN99817 173429-83-9 C25H24O5 = 404.5 10mg QQ客服:1413575084

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