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  • 宽缨酮

    Eurycomanone

    宽缨酮
    产品编号 CFN92008
    CAS编号 84633-29-4
    分子式 = 分子量 C20H24O9 = 408.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The roots of Eurycoma longifolia.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    宽缨酮 CFN92008 84633-29-4 10mg QQ客服:1457312923
    宽缨酮 CFN92008 84633-29-4 20mg QQ客服:1457312923
    宽缨酮 CFN92008 84633-29-4 50mg QQ客服:1457312923
    宽缨酮 CFN92008 84633-29-4 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Leipzig (Germany)
  • Sri Ramachandra University (India)
  • Universidade da Beira Interior (Germany)
  • Semmelweis Unicersity (Hungary)
  • Shanghai University of TCM (China)
  • University of Ioannina (Greece)
  • Mahatma Gandhi University (India)
  • Istanbul University (Turkey)
  • University of Pretoria (South Africa)
  • University of Cincinnati (USA)
  • University of Oslo (Norway)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Institute of Chinese Materia Medica (China)
  • University of Hertfordshire (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • FASEB J.2019, 33(2):2026-2036
  • Life (Basel).2022, 12(10):1630.
  • Korean Journal of Plant Resources2021, 34(1):52-58.
  • Phytother Res.2023, 37(10):4587-4606.
  • J Chromatogr A.2017, 1518:46-58
  • Antioxidants (Basel).2021, 10(11): 1802.
  • Planta Med.2016, 82(13):1208-16
  • Biomedicines.2022, 10(3):583.
  • Org Biomol Chem.2017, 15(31):6483-6492
  • Acta Physiologiae Plantarum2015, 37:1736
  • Biomedicines.2020, 8(11):486.
  • Plants (Basel).2021, 10(4):702.
  • Molecules.2021, 26(2):E255.
  • Life (Basel).2021, 11(7):616.
  • Huazhong Agricultural University2022, pp34.
  • Heliyon.2023, 9(12):e22932.
  • Biomed Pharmacother.2023, 166:115329.
  • LWT - Food Science and Technology2022, 164:113627
  • Biochemistry.2018, 57(40):5886-5896
  • Braz J Med Biol Res. 2016, 49(7)
  • Korean Herb. Med. Inf.2020, 8(2):233-242.
  • Int J Mol Sci.2022, 23(10):5813.
  • Phytochemistry Letters2021, 43:80-87.
  • ...
  • 生物活性
    Description: Eurycomanone has anti-cancer activity, it is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2.
    Targets: NF-kB | IkB | P450 (e.g. CYP17) | p53 | Bcl-2/Bax | Caspase | IKK
    In vitro:
    Molecules. 2014 Sep 16;19(9):14649-66.
    Eurycomanone and eurycomanol from Eurycoma longifolia Jack as regulators of signaling pathways involved in proliferation, cell death and inflammation.[Pubmed: 25230121]
    Eurycomanone and eurycomanol are two quassinoids from the roots of Eurycoma longifolia Jack.
    METHODS AND RESULTS:
    The aim of this study was to assess the bioactivity of these compounds in Jurkat and K562 human leukemia cell models compared to peripheral blood mononuclear cells from healthy donors. Both eurycomanone and eurycomanol inhibited Jurkat and K562 cell viability and proliferation without affecting healthy cells. Interestingly, eurycomanone inhibited NF-κB signaling through inhibition of IκBα phosphorylation and upstream mitogen activated protein kinase (MAPK) signaling, but not eurycomanol.
    CONCLUSIONS:
    In conclusion, both quassinoids present differential toxicity towards leukemia cells, and the presence of the α,β-unsaturated ketone in eurycomanone could be prerequisite for the NF-κB inhibition.
    Phytomedicine. 2012 Jan 15;19(2):138-44.
    Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28.[Pubmed: 21903368]
    Bioactive compounds from the medicinal plant, Eurycoma longifolia Jack have been shown to promote anti-proliferative effects on various cancer cell lines.
    METHODS AND RESULTS:
    Here we examined the effects of purified eurycomanone, a quassinoid found in Eurycoma longifolia Jack extract, on the expression of selected genes of the A549 lung cancer cells. Eurycomanone inhibited A549 lung cancer cell proliferation in a dose-dependent manner at concentrations ranging from 5 to 20 μg/ml. The concentration that inhibited 50% of cell growth (GI(50)) was 5.1 μg/ml. The anti-proliferative effects were not fully reversible following the removal of eurycomanone, in which 30% of cell inhibition still remained (p<0.0001, T-test). At 8 μg/ml (GI(70)), eurycomanone suppressed anchorage-independent growth of A549 cells by >25% (p<0.05, T-test, n=8) as determined using soft agar colony formation assay. Cisplatin, a chemotherapy drug used for the treatment of non small cell lung cancer on the other hand, inhibited A549 cells proliferation at concentrations ranging from 0.2 μg/ml to 15 μg/ml with a GI(50) of 0.58 μg/ml. The treatment with eurycomanone reduced the abundance expression of the lung cancer markers, heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1, p53 tumor suppressor protein and other cancer-associated genes including prohibitin (PHB), annexin 1 (ANX1) and endoplasmic reticulum protein 28 (ERp28) but not the house keeping genes. The mRNA expressions of all genes with the exception of PHB were significantly downregulated, 72 h after treatment (p<0.05, T-test, n=9). These findings suggest that eurycomanone at viable therapeutic concentrations of 5-20 μg/ml exhibited significant anti-proliferative and anti-clonogenic cell growth effects on A549 lung cancer cells.
    CONCLUSIONS:
    The treatment also resulted in suppression of the lung cancer cell tumor markers and several known cancer cell growth-associated genes.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4486 mL 12.2429 mL 24.4858 mL 48.9716 mL 61.2145 mL
    5 mM 0.4897 mL 2.4486 mL 4.8972 mL 9.7943 mL 12.2429 mL
    10 mM 0.2449 mL 1.2243 mL 2.4486 mL 4.8972 mL 6.1214 mL
    50 mM 0.049 mL 0.2449 mL 0.4897 mL 0.9794 mL 1.2243 mL
    100 mM 0.0245 mL 0.1224 mL 0.2449 mL 0.4897 mL 0.6121 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    宽缨酮; Eurycomanone CFN92008 84633-29-4 C20H24O9 = 408.4 20mg QQ客服:2159513211
    Pasakbumin B; Pasakbumin B CFN92009 138809-10-6 C20H24O10 = 424.4 5mg QQ客服:215959384
    鸦胆子素 D; Bruceine D CFN90771 21499-66-1 C20H26O9 = 410.4 20mg QQ客服:2056216494
    鸦胆苦内酯C; Yadanziolide C CFN96426 95258-12-1 C20H26O9 = 410.41 5mg QQ客服:3257982914
    鸦胆苦内酯B; Yadanziolide B CFN96427 95258-13-2 C20H26O11 = 442.41 5mg QQ客服:3257982914
    鸦胆苦内酯A; Yadanziolide A CFN96428 95258-14-3 C20H26O10 = 426.41 10mg QQ客服:1457312923
    鸦胆子素E; Bruceine E CFN89340 21586-90-3 C20H28O9 = 412.43 20mg QQ客服:1457312923
    鸦胆子苷I; Yadanzioside I CFN96421 99132-95-3 C29H38O16 = 642.60 5mg QQ客服:2159513211
    鸦胆子苷P; Yadanzioside P CFN96417 79439-84-2 C34H46O16 = 710.72 5mg QQ客服:2056216494
    鸦胆子苷L ; Yadanzioside L CFN96419 99132-97-5 C34H46O17 = 726.72 5mg QQ客服:1457312923

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