(E)-阿魏酸乙酯

Ethyl (E)-ferulate

	产品编号	CFN92310
	CAS编号	28028-62-8
	分子式 = 分子量	C₁₂H₁₄O₄ = 222.2
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenylpropanoids
	植物来源	The roots of Solanum integrifolium
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
(E)-阿魏酸乙酯	CFN92310	28028-62-8	10mg	QQ客服：1413575084
(E)-阿魏酸乙酯	CFN92310	28028-62-8	20mg	QQ客服：1413575084
(E)-阿魏酸乙酯	CFN92310	28028-62-8	50mg	QQ客服：1413575084
(E)-阿魏酸乙酯	CFN92310	28028-62-8	100mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Kyushu University (Japan)

Aveiro University (Portugal)

University of Canterbury (New Zealand)

National Hellenic Research Foundation (Greece)

Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)

University of Queensland (Australia)

University of East Anglia (United Kingdom)

University of Beira Interior (Portugal)

National Research Council of Canada (Canada)

Ain Shams University (Egypt)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

University of Illinois at Chicago (USA)

University of Auckland (New Zealand)

Vin?a Institute of Nuclear Sciences (Serbia)

More...

Description:

Ethyl ferulate could be used for therapeutic purposes as a potent inducer of HO-1 for the protection of brain cells against oxidative and neurodegenerative conditions.

Targets:

HO-1

In vitro:

Journal of Biotechnology, 2013, 164(2):340-345.

Solvent-free enzymatic transesterification of ethyl ferulate and monostearin: Optimized by response surface methodology.[Reference: WebLink]

In the CNS, the heme oxygenase (HO) system has been reported to be active and to operate as a fundamental defensive mechanism for neurons exposed to an oxidant challenge. We have recently shown that both curcumin and caffeic acid phenethyl ester, two phenolic natural compounds, potently induce HO-1 expression and activity in rat astrocytes. We have extended our previous findings examining the effects of two other plant-derived phenolic compounds, with analogous chemical structures, in rat astrocytes and neurons.
METHODS AND RESULTS:
Ethyl ferulate (Ethyl (E)-ferulate, ethyl 4-hydroxy-3-methoxycinnamate) (EFE), the naturally occurring ester of ferulic acid, was able to induce HO-1 protein expression. Maximal expression of HO-1 mRNA and protein and a significant increase in HO activity were detected after 6 h of incubation with 15 microM EFE in astrocytes and 5 microM EFE in neurons. Higher concentrations of EFE (50 microM) caused a substantial cytotoxic effect with no change in HO-1 protein expression and activity. Exposure of astrocytes to resveratrol, a phytoalexin derived from grapes, resulted in an increase of HO-1 mRNA, but it was not able to induce HO-1 protein expression and activity. Interestingly, preincubation (12 h) of neurons with EFE resulted in an enhanced cellular resistance to glucose oxidase-mediated oxidative damage; this cytoprotective effect was considerably attenuated by zinc protoporphyrin IX, an inhibitor of HO activity.
CONCLUSIONS:
This study identifies a novel natural compound that could be used for therapeutic purposes as a potent inducer of HO-1 for the protection of brain cells against oxidative and neurodegenerative conditions.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
反式-阿魏酸对羟基苯乙酯; p-Hydroxyphenethyl trans-ferulate	CFN96089	84873-15-4	C₁₈H₁₈O₅ = 314.3	5mg	QQ客服：215959384
橄榄苦苷元; Oleuropein aglycone	CFN91625	31773-95-2	C₁₉H₂₂O₈ = 378.4	5mg	QQ客服：1413575084
知母皂苷C; Timorsaponin C	CFN90779	185432-00-2	C₄₅H₇₄O₁₈ = 903.1	5mg	QQ客服：2159513211
9-当酰倒千里光碱氮氧化物; 9-Angeloylretronecine N-oxide	CFN00325	27773-86-0	C₁₃H₁₉NO₄ = 253.30	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.5005 mL	22.5023 mL	45.0045 mL	90.009 mL	112.5113 mL
5 mM	0.9001 mL	4.5005 mL	9.0009 mL	18.0018 mL	22.5023 mL
10 mM	0.45 mL	2.2502 mL	4.5005 mL	9.0009 mL	11.2511 mL
50 mM	0.09 mL	0.45 mL	0.9001 mL	1.8002 mL	2.2502 mL
100 mM	0.045 mL	0.225 mL	0.45 mL	0.9001 mL	1.1251 mL