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  • 麦角甾-7,22-二烯-3-酮

    Ergosta-7,22-dien-3-one

    麦角甾-7,22-二烯-3-酮
    产品编号 CFN96785
    CAS编号 32507-77-0
    分子式 = 分子量 C28H44O = 396.65
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The aerial parts of Paris polyphylla var. chinensis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    麦角甾-7,22-二烯-3-酮 CFN96785 32507-77-0 1mg QQ客服:1457312923
    麦角甾-7,22-二烯-3-酮 CFN96785 32507-77-0 5mg QQ客服:1457312923
    麦角甾-7,22-二烯-3-酮 CFN96785 32507-77-0 10mg QQ客服:1457312923
    麦角甾-7,22-二烯-3-酮 CFN96785 32507-77-0 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Medical University of Gdansk (Poland)
  • Complutense University of Madrid (Spain)
  • Charles University in Prague (Czech Republic)
  • Georgia Institute of Technology (USA)
  • Melbourne University (Australia)
  • FORTH-IMBB (Greece)
  • Griffith University (Australia)
  • University of the Basque Country (Spain)
  • Istanbul University (Turkey)
  • Indian Institute of Science (India)
  • University of Brasilia (Brazil)
  • University of Illinois (USA)
  • University of Zurich (Switzerland)
  • University Medical Center Mainz (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nutrients.2018, 10(10)
  • Cell Signal.2022, 99:110433.
  • Tumour Biol.2015, 36(9):7027-34
  • Heinrich Heine University Dusseldorf2021, 62203.
  • Journal of Molecular Liquids2021, 334:116014.
  • Phytomedicine.2022, 110:154597.
  • J Ethnopharmacol.2020, 249:112396
  • Cell Rep.2020, 32(11):108158.
  • Anat Rec (Hoboken).2021, 304(2):323-332.
  • Nutrients.2019, 11(11):E2694
  • Daru.2022, 30(2):273-288.
  • Pharmaceutics.2020, 12(9):882.
  • iScience.2020, 23(2):100849.
  • In Vitro Cellular & Developmental Biology - Plant2022, 58:972-988.
  • J Korean Soc Food Sci Nutr2023, 52(11):1101-1110
  • Ind. J. Pharm. Edu. Res.2023; 57(3):1132-1139.
  • Environ Toxicol.2020, doi: 10.1002
  • Neurochem Int.2020, 133:104629
  • Horticulturae2023, 9(2), 213.
  • Processes2021, 9(1), 153;
  • Evid Based Complement Alternat Med.2021, 2021:8847358.
  • Theranostics.2023, 13(9):3103-3116.
  • Food and Fermentation Industries2019, 45(7):45-51
  • ...
  • 生物活性
    Description: Ergosta-7,22-dien-3-one shows pro-inflammatory property, it can stimulate nitric oxide production, induce the expression of genes, and induce the production of TLRs, cytokines, chemokines, and cellular adhesion molecules in J774A.1 cells.
    Targets: LTR | NO
    In vitro:
    Int J Med Mushrooms. 2017;19(3):203-211.
    In Vitro Expression of Toll-Like Receptors and Proinflammatory Molecules Induced by Ergosta- 7,22-Dien-3-One Isolated from a Wild Mexican Strain of Ganoderma oerstedii (Agaricomycetes).[Pubmed: 28605335 ]
    Compounds showing pharmacological activity on the immune system are of interest because of their therapeutic potential in the treatment of many diseases. However, data from primary human immune cells and in vivo studies are limited.
    METHODS AND RESULTS:
    The aim of this study was to analyze the ability to induce the expression of Toll-like receptors (TLRs) and proinflammatory molecules on cells involved in the immune system using the compound ergosta-7,22-dien-3- one, isolated from a wild Mexican strain of Ganoderma oerstedii. According to our study, Ergosta-7,22-dien-3-one did not present any cytotoxic effect on HeLa or J774A.1 cells, and it was able to stimulate nitric oxide production, induce the expression of genes, and induce the production of TLRs, cytokines, chemokines, and cellular adhesion molecules in J774A.1 cells, based on reverse-transcriptase polymerase chain reaction and enzyme-linked immunosorbent assay.
    CONCLUSIONS:
    Here we report a new pro-inflammatory property of Ergosta-7,22-dien-3-one, which should be considered as a possible adjuvant property in view of its biological activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5211 mL 12.6056 mL 25.2111 mL 50.4223 mL 63.0279 mL
    5 mM 0.5042 mL 2.5211 mL 5.0422 mL 10.0845 mL 12.6056 mL
    10 mM 0.2521 mL 1.2606 mL 2.5211 mL 5.0422 mL 6.3028 mL
    50 mM 0.0504 mL 0.2521 mL 0.5042 mL 1.0084 mL 1.2606 mL
    100 mM 0.0252 mL 0.1261 mL 0.2521 mL 0.5042 mL 0.6303 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5,8-Epidioxyergosta-6,9(11),22-trien-3-ol; 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol CFN93118 86363-50-0 C28H42O3 = 426.63 5mg QQ客服:215959384
    过氧麦角甾醇; Ergosterol peroxide CFN98035 2061-64-5 C28H44O3 = 428.7 10mg QQ客服:2056216494
    过氧麦角甾醇 3-O-beta-D-吡喃葡萄糖苷; Ergosterol peroxide glucoside CFN99458 140447-22-9 C34H54O8 = 590.8 5mg QQ客服:2056216494
    表油菜素内酯; Epibrassinolide CFN80268 72962-43-7 C28H48O6 = 480.34 5mg QQ客服:1457312923
    猪苓酮A; Polyporusterone A CFN91564 141360-88-5 C28H46O6 = 478.7 10mg QQ客服:1457312923
    猪苓酮B; Polyporusterone B CFN91703 141360-89-6 C28H44O6 = 476.7 10mg QQ客服:1413575084
    菜油甾醇; Campesterol CFN92204 474-62-4 C28H48O = 400.7 10mg QQ客服:1457312923
    菜籽甾醇; Brassicasterol CFN90471 474-67-9 C28H46O = 398.66 5mg QQ客服:215959384
    星鱼甾醇; Stellasterol CFN98267 2465-11-4 C28H46O = 398.7 20mg QQ客服:2056216494
    麦角甾-7,22-二烯-3-酮; Ergosta-7,22-dien-3-one CFN96785 32507-77-0 C28H44O = 396.65 5mg QQ客服:3257982914

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