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  • 恩贝灵; 恩贝酸

    Embelin

    恩贝灵; 恩贝酸
    产品编号 CFN90537
    CAS编号 550-24-3
    分子式 = 分子量 C17H26O4 = 294.38
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Quinones
    植物来源 The herbs of Paederia scandens (Lour.) Merr
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    恩贝灵; 恩贝酸 CFN90537 550-24-3 10mg QQ客服:3257982914
    恩贝灵; 恩贝酸 CFN90537 550-24-3 20mg QQ客服:3257982914
    恩贝灵; 恩贝酸 CFN90537 550-24-3 50mg QQ客服:3257982914
    恩贝灵; 恩贝酸 CFN90537 550-24-3 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universit?t Basel (Switzerland)
  • Harvard University (USA)
  • S.N.D.T. Women's University (India)
  • Wroclaw Medical University (Poland)
  • The Ohio State University (USA)
  • Tokyo Woman's Christian University (Japan)
  • Griffith University (Australia)
  • Korea Institute of Oriental Medicine (Korea)
  • University of Oslo (Norway)
  • The University of Newcastle (Australia)
  • Stanford University (USA)
  • Hamdard University (India)
  • Northeast Normal University Changchun (China)
  • Almansora University (Egypt)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • bioRxiv - Molecular Biology2023, 535548.
  • Asian J Beauty Cosmetol2021, 19(1): 57-64.
  • J Adv Res.2019, 17:85-94
  • Sci Rep.2017, 7(1):3249
  • J Sci Food Agric.2018, 98(3):1153-1161
  • Biomed Pharmacother.2020, 125:109784.
  • Current Topics in Nutraceutical Research2021, 19(1),p90-105.
  • Mol Med Rep.2024, 29(2):26.
  • International. J. of Food Properties 2017, 20:S131-S140
  • J Chromatogr B Analyt Technol Biomed Life Sci. 2017, 1064:115-123
  • Evid Based Complement Alternat Med.2022, 2022:3483511
  • Food Science and Biotechnology2022, 10.1007.
  • QASCF2022, 14(4).
  • Org Biomol Chem.2017, 15(31):6483-6492
  • Evid Based Complement Alternat Med.2022, 2022:1307173.
  • Neuropharmacology2019, 151437
  • Plant Cell Physiol.2018, 59(1):128-141
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Int J Mol Sci.2022, 23(20):12516.
  • Separation Science Plus2022, sscp.202200048.
  • J Ethnopharmacol.2017, 206:73-77
  • J Ginseng Res.2020, 44(4):611-618.
  • Antioxidants (Basel).2020, 9(6):526.
  • ...
  • 生物活性
    Description: Embelin is an inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 μM in a cell-free assay.Embelin has antitumor, antioxidant and anti-inflammatory activities. Embelin can enhance TRAIL-induced cell apoptosis through DR4 and DR5 upregulation and decrease IL-6-induced STAT3 phosphorylation, that combination of low-toxicity Embelin and TRAIL may become as a potential antileukemia strategy.
    Targets: STAT | p53 | IL Receptor | gp120/CD4 | NF-kB | TNF-α | VEGFR | MMP(e.g.TIMP) | XIAP | DR4 | DR5
    In vitro:
    Tumour Biol. 2015 Feb;36(2):769-77.
    The XIAP inhibitor Embelin enhances TRAIL-induced apoptosis in human leukemia cells by DR4 and DR5 upregulation.[Pubmed: 25293521]
    The present study was designed to explore the effects of low-toxicity Embelin on TRAIL-induced apoptosis and its possible mechanism in human leukemia cells.
    METHODS AND RESULTS:
    Our study showed that low-toxicity Embelin enhanced TRAIL-induced apoptosis through DR4 and DR5 upregulation and caspase activation in HL-60 cells. Pan-caspase inhibitor Z-VAD-FMK inhibited cell apoptosis induced by TRAIL alone or combined with low-toxicity Embelin, which indicated the cytotoxic effect is mediated by caspase-dependent apoptosis. Although Embelin is an X chromosome-linked inhibitor-of-apoptosis protein (XIAP) inhibitor, an XIAP independent effect on cell death was detected in HL-60 cells exposed to low-toxicity Embelin and TRAIL. Low-toxicity Embelin upregulated DR4 and DR5 expression to enhance TRAIL-induced apoptosis. The sensitizing effects of Embelin on TRAIL-induced apoptosis were markedly attenuated when DR4/DR5 was knocked down.
    CONCLUSIONS:
    These data suggested that low-toxicity Embelin enhanced TRAIL-induced cell apoptosis through DR4 and DR5 upregulation, indicating that combination of low-toxicity Embelin and TRAIL may become as a potential antileukemia strategy.
    BMC Cancer. 2014 Oct 22;14:775.
    Embelin inhibits TNF-α converting enzyme and cancer cell metastasis: molecular dynamics and experimental evidence.[Pubmed: 25336399]
    Embelin, a quinone derivative, is found in the fruits of Embelia ribes Burm (Myrsinaceae). It has been shown to have a variety of therapeutic potentials including anthelmintic, anti-tumor, anti-diabetic, anti-bacterial and anti-inflammation. Several studies have shown that the anti-inflammatory activity of Embelin is mediated by reduction in TNF-α. The latter is synthesized as a membrane anchored protein (pro-TNF-α); the soluble component of pro-TNF-α is then released into the extracellular space by the action of a protease called TNF-α converting enzyme (TACE). TACE, hence, has been proposed as a therapeutic target for inflammation and cancer.
    METHODS AND RESULTS:
    We used molecular docking and experimental approaches to investigate the docking potential and molecular effects of Embelin to TACE and human cancer cell characteristics, respectively. We demonstrate that Embelin is a potential inhibitor of TACE. Furthermore, in vitro studies revealed that it inhibits malignant properties of cancer cells through inactivation of metastatic signaling molecules including MMPs, VEGF and hnRNP-K in breast cancer cells.
    CONCLUSIONS:
    Based on the molecular dynamics and experimental data, Embelin is proposed as a natural anti-inflammatory and anticancer drug.
    In vivo:
    Mol Cancer Ther. 2014 May;13(5):1206-16.
    Embelin reduces colitis-associated tumorigenesis through limiting IL-6/STAT3 signaling.[Pubmed: 24651526]
    Embelin is a small molecule inhibitor of X-linked inhibitor of apoptosis protein (XIAP), with antioxidant, anti-inflammatory, and antitumor activities. We previously showed that Embelin inhibits the growth of colon cancer cells in vitro, and effectively suppresses 1,2-dimethylhydrazine dihydrochloride-induced colon carcinogenesis in mice.
    METHODS AND RESULTS:
    Here, we explored the antitumor effects and mechanisms of Embelin on colitis-associated cancer (CAC) using the azoxymethane/dextran sulfate sodium (AOM/DSS) model, with a particular focus on whether Embelin exerts its effect through the IL-6/STAT3 pathway. We found that Embelin significantly reduced incidence and tumor size in CAC-bearing mice. In addition to inhibiting proliferation of tumor epithelial cells, Embelin suppressed colonic IL-6 expression and secretion, and subsequently STAT3 activation in vivo. Importantly, in vitro studies have revealed that in colon cancer cells, Embelin diminished both the constitutive and IL-6-induced STAT3 activation by stimulating Src homology domain 2-containing protein tyrosine phosphatase (SHP2) activity. Moreover, Embelin protected mice from AOM/DSS-induced colitis before tumor development. Embelin decreased IL-1β, IL-17a, and IL-23a expression as well as the number of CD4(+) T cells and macrophages infiltrating the colonic tissues.
    CONCLUSIONS:
    Thus, our findings demonstrated that Embelin suppresses CAC tumorigenesis, and its antitumor effect is partly mediated by limiting IL-6/STAT3 activation and Th17 immune response. Embelin may be a potential agent in the prevention and treatment of CAC.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.397 mL 16.9848 mL 33.9697 mL 67.9394 mL 84.9242 mL
    5 mM 0.6794 mL 3.397 mL 6.7939 mL 13.5879 mL 16.9848 mL
    10 mM 0.3397 mL 1.6985 mL 3.397 mL 6.7939 mL 8.4924 mL
    50 mM 0.0679 mL 0.3397 mL 0.6794 mL 1.3588 mL 1.6985 mL
    100 mM 0.034 mL 0.1698 mL 0.3397 mL 0.6794 mL 0.8492 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4-羟基红根草对醌; 4-Hydroxysapriparaquinone CFN97936 120278-25-3 C20H26O4 = 330.4 5mg QQ客服:2056216494
    Salvisyrianone; Salvisyrianone CFN97952 250691-57-7 C20H24O3 = 312.4 5mg QQ客服:215959384
    樱草素; Primin CFN90588 15121-94-5 C12H16O3 = 208.26 10mg QQ客服:1413575084
    2,5-二羟基-3-壬烷基-1,4-苯醌; Homoembelin CFN91184 38363-99-4 C15H22O4 = 266.3 5mg QQ客服:3257982914
    恩贝灵; 恩贝酸; Embelin CFN90537 550-24-3 C17H26O4 = 294.38 20mg QQ客服:215959384
    酸藤子醌; Rapanone CFN91185 573-40-0 C19H30O4 = 322.4 10mg QQ客服:3257982914
    α-托可醌; alpha-Tocopherolquinone CFN97235 7559-04-8 C29H50O3 = 446.7 20mg QQ客服:2056216494
    辅酶Q10; Coenzyme Q10 CFN99165 303-98-0 C59H90O4 = 863.36 20mg QQ客服:1457312923
    维生素 K1; Vitamin K1 CFN90050 84-80-0 C31H46O2 = 450.7 20mg QQ客服:2056216494

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