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  • 茅膏醌

    Droserone

    茅膏醌
    产品编号 CFN91989
    CAS编号 478-40-0
    分子式 = 分子量 C11H8O4 = 204.18
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Quinones
    植物来源 The herbs of Plumbago zeylanica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    茅膏醌 CFN91989 478-40-0 1mg QQ客服:1413575084
    茅膏醌 CFN91989 478-40-0 5mg QQ客服:1413575084
    茅膏醌 CFN91989 478-40-0 10mg QQ客服:1413575084
    茅膏醌 CFN91989 478-40-0 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Melbourne University (Australia)
  • University of Dicle (Turkey)
  • Universidad de Antioquia (Colombia)
  • University of Perugia (Italy)
  • Subang Jaya Medical Centre (Malaysia)
  • Periyar University (India)
  • VIT University (India)
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  • Universite de Lille1 (France)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Metab Eng.2022, 75:143-152.
  • Industrial Crops and Products2021, 163:113313.
  • LWT2021, 138:110630.
  • Crystals2020, 10(3), 206.
  • Metabolites.2023, 13(5):625.
  • Biomolecules.2020, 10(6):925.
  • ACS Chem Biol.2019, 14(5):873-881
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Int J Mol Sci.2017, 18(5)
  • Recent Pat Anticancer Drug Discov.2022, 17(4):416-426.
  • Chin J Appl. Physiol.2019, 35(3):283-288
  • Int J Mol Sci.2022, 23(10):5813.
  • J Cell Mol Med.2023, jcmm.17968.
  • Applied Biological Chemistry 2022, 65,5(2022).
  • Biomed Pharmacother.2022, 145:112410.
  • J Agric Food Chem.2020, 68(43):12164-12172.
  • Foods.2021, 10(11):2627.
  • Int J Mol Sci.2020, 21(8):2790.
  • Molecules.2019, 24(10):E1930
  • Pharmacol Rep.2020, 72(2):472-480.
  • Key Engineering Materials2022, 931(47-53).
  • Mol Cells.2015, 38(9):765-72
  • J AOAC Int.2021, 104(6):1634-1651.
  • ...
  • 生物活性
    Description: Droserone exerts an antifungal effect on a wide range of plant and human fungal pathogens. Droserone inhibits in vitro measles virus infection.
    Targets: Antifection
    In vitro:
    Planta Med. 2017 Feb;83(3-04):232-238.
    The Plant-Derived Naphthoquinone Droserone Inhibits In Vitro Measles Virus Infection.[Pubmed: 27420351 ]
    The naphthoquinone Droserone (1) is a natural product occurring in dicotyledonous plants.
    METHODS AND RESULTS:
    We have now observed that the addition of 1 during infection of tissue culture cells with measles virus considerably reduced the infection. Interestingly, the infection was inhibited only when Droserone (1) was added during virus entry, but not when added to the cells prior to virus uptake or after virus uptake. These findings suggest that 1 interacts with viral particles to reduce infectivity. The formation of progeny measles virus particles was inhibited to 50 % by Droserone (1) at a concentration (IC50) of approximately 2 μM with a half-maximal cytotoxicity (CC50) of about 60 μM for Vero cells. Other tested naphthoquinone derivatives, among them the likewise natural plumbagin (2), but also synthetic analogs, were either more cytotoxic or not as effective as 1.
    CONCLUSIONS:
    Thus, our data do not support the development of naphthoquinone derivatives into antiviral compounds, but suggest that they may be interesting research tools to study measles virus entry into cells.
    J Exp Bot. 2010 Mar;61(3):911-22.
    Induced production of antifungal naphthoquinones in the pitchers of the carnivorous plant Nepenthes khasiana.[Pubmed: 20018905]
    Nepenthes spp. are carnivorous plants that have developed insect capturing traps, evolved by specific modification of the leaf tips, and are able to utilize insect degradation products as nutritional precursors. A chitin-induced antifungal ability, based on the production and secretion to the trap liquid of Droserone and 5-O-methylDroserone, is described here.
    METHODS AND RESULTS:
    Such specific secretion uniquely occurred when chitin injection was used as the eliciting agent and probably reflects a certain kind of defence mechanism that has been evolved for protecting the carnivory-based provision of nutritional precursors. The pitcher liquid containing Droserone and 5-O-methylDroserone at 3:1 or 4:1 molar ratio, as well as the purified naphthoquinones, exerted an antifungal effect on a wide range of plant and human fungal pathogens. When tested against Candida and Aspergillus spp., the concentrations required for achieving inhibitory and fungicidal effects were significantly lower than those causing cytotoxicity in cells of the human embryonic kidney cell line, 293T.
    CONCLUSIONS:
    These naturally secreted 1,4-naphthoquinone derivatives, that are assumed to act via semiquinone enhancement of free radical production, may offer a new lead to develop alternative antifungal drugs with reduced selectable pressure for potentially evolved resistance.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.8976 mL 24.4882 mL 48.9764 mL 97.9528 mL 122.441 mL
    5 mM 0.9795 mL 4.8976 mL 9.7953 mL 19.5906 mL 24.4882 mL
    10 mM 0.4898 mL 2.4488 mL 4.8976 mL 9.7953 mL 12.2441 mL
    50 mM 0.098 mL 0.4898 mL 0.9795 mL 1.9591 mL 2.4488 mL
    100 mM 0.049 mL 0.2449 mL 0.4898 mL 0.9795 mL 1.2244 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Prerubialatin; Prerubialatin CFN96585 1667718-89-9 C27H20O7 = 456.45 5mg QQ客服:3257982914
    2,6-二甲氧基-1-乙酰甲基氢醌; 2,6-Dimethoxy-1-acetonylquinol CFN98207 2215-96-5 C11H14O5 = 226.2 5mg QQ客服:1413575084
    (1-羟基-4-氧代-2,5-环己二烯-1-基)乙酸乙酯; Ethyl(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)acetate CFN97022 60263-06-1 C10H12O4 = 196.2 5mg QQ客服:1457312923
    叶点霉素; Phyllostine CFN97901 27270-89-9 C7H6O4 = 154.1 5mg QQ客服:1413575084
    (4R)-3,4-二氢-4,8-二羟基-1(2H)-萘酮; Regiolone CFN96886 137494-04-3 C10H10O3 = 178.18 5mg QQ客服:3257982914
    2-羟基-1,4萘醌; 2-Hydroxy-1,4-naphoquinone CFN91715 83-72-7 C10H6O3 = 174.15 20mg QQ客服:2159513211
    胡桃酮,5-羟基对萘醌; Juglone CFN90497 481-39-0 C10H6O3 = 174.16 20mg QQ客服:1413575084
    2-甲氧基-1,4-萘并醌; 2-Methoxy-1,4-naphthoquinone CFN95269 2348-82-5 C11H8O3 = 188.2 20mg QQ客服:2159513211
    兰雪醌; Plumbagin CFN90444 481-42-5 C11H8O3 = 188.17 20mg QQ客服:1413575084
    梅笠草素; Chimaphilin CFN95676 482-70-2 C12H10O2 = 186.2 20mg QQ客服:2056216494

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