| In vitro: |
| Phytochemistry. 2004 Jul;65(14):2173-6. | | Insect antifeedant compounds from Nothofagus dombeyi and N. pumilio.[Pubmed: 15279992] |
METHODS AND RESULTS:
A bioassay-guided purification of the extracts of Nothofagus dombeyi and N. pumilio leaves yielded several triterpenes and flavonoids including 2-O-acetylmaslinic acid, 3-O-acetyl 20,24,25-trihydroxydammarane, and 3,20,24,25-tetrahydroxydammarane as new natural products. All the isolated compounds were assessed for antifeeding activity against the 5th instar larvae of Ctenopsteustis obliquana.
CONCLUSIONS:
12-Hydroxyoleanolic lactone and pectolinarigenin from N. dombeyi and Dihydrooroxylin A from N. pumilio, showed significant antifeeding activity. |
|
| In vivo: |
| Biol Pharm Bull. 1998 Dec;21(12):1251-7. | | Characteristics of delayed excretion of flavonoids in human urine after administration of Shosaiko-to, a herbal medicine.[Pubmed: 9881633 ] |
METHODS AND RESULTS:
Two flavanones, S-dihydrowogonin and S-Dihydrooroxylin A, were identified as the metabolites of wogonin and oroxylin A, respectively. Excretion rate-time curves of the flavonoids were divided into three types of structure-dependent absorption, i.e. (1) the fast absorption of herbal-origin aglycons, (2) the moderately-delayed absorption of aglycons derived from herbal glycosides, and (3) markedly-delayed absorption after the molecular transformation of herbal compounds. Individual excretion profiles seemed to depend on microflora activities.
CONCLUSIONS:
Two types of flavanones, S-dihydrowogonin and S-Dihydrooroxylin A, were found in a half of the volunteers, suggesting there might be two kinds of volunteers, namely, rapid and poor metabolizers of flavonoids. |
|
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