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  • 二氢吴茱萸新碱,二氢吴茱萸卡品碱

    Dihydroevocarpine

    二氢吴茱萸新碱,二氢吴茱萸卡品碱
    产品编号 CFN92786
    CAS编号 15266-35-0
    分子式 = 分子量 C23H35NO = 341.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The fruits of Evodia rutaecarpa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    二氢吴茱萸新碱,二氢吴茱萸卡品碱 CFN92786 15266-35-0 1mg QQ客服:1457312923
    二氢吴茱萸新碱,二氢吴茱萸卡品碱 CFN92786 15266-35-0 5mg QQ客服:1457312923
    二氢吴茱萸新碱,二氢吴茱萸卡品碱 CFN92786 15266-35-0 10mg QQ客服:1457312923
    二氢吴茱萸新碱,二氢吴茱萸卡品碱 CFN92786 15266-35-0 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Cincinnati (USA)
  • University of Vienna (Austria)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • University of Pretoria (South Africa)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Utrecht University (Netherlands)
  • Chiang Mai University (Thailand)
  • National Cancer Institute (USA)
  • The University of Newcastle (Australia)
  • Georgia Institute of Technology (USA)
  • University of the Basque Country (Spain)
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  • Donald Danforth Plant Science Center (USA)
  • Osmania University (India)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Pharmacol.2022, 13:919230.
  • Auburn University2015, 1-58
  • Research Square2021, March 3rd.
  • Int J Anal Chem.2017, 2017:1254721
  • Integr Med Res.2017, 6(4):395-403
  • J Applied Biological Chemistry2021, 64(2):185-192
  • Molecules.2022, 27(4):1412.
  • Srinagarind Medical Journal2019, 34(1)
  • Nutrients.2019, 11(11):E2694
  • Phytomedicine.2015, 22(14):1262-8
  • FASEB J.2022, 36(7):e22387.
  • Data Science for Genomics2023, 107-128.
  • Cytotechnology.2017, 69(5):765-773
  • Chemistry of Natural Compounds2020, 56,423-426
  • Antioxidants (Basel).2020, 9(2):E99
  • Biomed Pharmacother.2019, 116:108987
  • Drug Chem Toxicol.2020, 1-14.
  • Front Pharmacol.2019, 10:1355
  • Applied Biological Chemistry2023, 66(58):112.
  • LWT2021, 138:110630.
  • Int J Mol Sci.2020, 21(19):7209.
  • Biomedicine & Pharmacotherapy2020, 125:109950
  • Life (Basel).2021, 11(7):616.
  • ...
  • 生物活性
    Description: Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is a moderate modulator of p-glycoprotein (p-gp) activity; it shows more potent inhibitory effects against MAO-B compared to MAO-A.
    Targets: P-gp | Antifection | MAO
    In vitro:
    Planta Med. 2007 Dec;73(15):1554-7.
    Cytotoxicity and p-glycoprotein modulating effects of quinolones and indoloquinazolines from the Chinese herb Evodia rutaecarpa.[Pubmed: 18058680 ]
    The antimycobacterial quinolones 1-methyl-2-undecyl-4-quinolone, Dihydroevocarpine and evocarpine as well as the indoloquinazoline alkaloids rutaecarpine and evodiamine - all from the Chinese medicinal herb Evodia rutaecarpa - were tested in two in vitro assays, for cytotoxicity and interaction with p-glycoprotein (p-gp).
    METHODS AND RESULTS:
    Cytotoxicity was measured in a cell proliferation assay against CCRF-CEM leukemia cells and their p-gp over-expressing subline CEM/ADR5000. An assay monitoring the p-gp-dependent accumulation of the dye calcein in porcine brain capillary endothelial cells (PBCECs) was used to study interactions of the test substances with this efflux pump. Rutaecarpine and evodiamine showed quite high toxicity with IC (50) values from 2.64 to 4.53 microM and were weak modulators of p-gp activity.
    CONCLUSIONS:
    The degrees of resistance in CEM/ADR5000 towards the saturated quinolones 1-methyl-2-undecyl-4-quinolone and Dihydroevocarpine were between 3 and 4. In the calcein assay, these two quinolones were shown to be moderate modulators of p-gp activity. Evocarpine, on the other side, is not transported by p-gp, and showed only slight toxicity at the highest test concentration of 30 microM.
    Biol Pharm Bull. 1999 Oct;22(10):1141-3.
    Anti-Helicobacter pylori activity of quinolone alkaloids from Evodiae fructus.[Pubmed: 10549874]
    A biologically monitored fractionation of methanol extract of the fruit of Evodia rutaecarpa led to the isolation of six quinolone alkaloids, evocarpine (1), 1-methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (2), 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolo ne (3), 1-methyl-2-undecyl-4(1H)-quinolone (4), dihydroevocarpine (5), 1-methyl-2-pentadecyl-4(1H)-quinolone (6).
    METHODS AND RESULTS:
    They showed potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. However, they had no effect on Helicobacter pylori urease activity at the concentration of 300 microg/ml.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9283 mL 14.6413 mL 29.2826 mL 58.5652 mL 73.2064 mL
    5 mM 0.5857 mL 2.9283 mL 5.8565 mL 11.713 mL 14.6413 mL
    10 mM 0.2928 mL 1.4641 mL 2.9283 mL 5.8565 mL 7.3206 mL
    50 mM 0.0586 mL 0.2928 mL 0.5857 mL 1.1713 mL 1.4641 mL
    100 mM 0.0293 mL 0.1464 mL 0.2928 mL 0.5857 mL 0.7321 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    1-甲基-2-戊基-4(1H)-喹啉酮; 1-Methyl-2-pentyl-4(1H)-quinolinone CFN98094 22048-98-2 C15H19NO = 229.3 10mg QQ客服:215959384
    青花椒碱; Schinifoline CFN97283 80554-58-1 C17H23NO = 257.4 10mg QQ客服:215959384
    1-甲基-2-壬基喹啉-4(1H)-酮; 1-Methyl-2-nonylquinolin-4(1H)-one CFN96290 68353-24-2 C19H27NO = 285.4 5mg QQ客服:1413575084
    1-甲基-2-十一烷基喹啉-4(1H)-酮; 1-Methyl-2-undecylquinolin-4(1H)-one CFN96296 59443-02-6 C21H31NO = 313.5 5mg QQ客服:2159513211
    1-甲基-2-(6Z)-6-十一碳烯-1-基-4(1H)-喹啉酮; (Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one CFN96758 120693-49-4 C21H29NO = 311.46 5mg QQ客服:1413575084
    吴茱萸新碱 ; Evocarpine CFN96759 15266-38-3 C23H33NO = 339.52 5mg QQ客服:2056216494
    二氢吴茱萸新碱,二氢吴茱萸卡品碱; Dihydroevocarpine CFN92786 15266-35-0 C23H35NO = 341.5 10mg QQ客服:2159513211
    1-甲基-2-[(6Z,9Z)-6,9-十五二烯基]-4(1H)-喹诺酮; 1-Methyl-2-[(6Z,9Z)-6,9-pentadecadiene]-4(1H)-quinolone CFN91687 120693-52-9 C25H35NO = 365.6 5mg QQ客服:1457312923
    犬尿喹啉酸; Kynurenic acid CFN90072 492-27-3 C10H7NO3 = 189.17 20mg QQ客服:1413575084
    1,4-二氢-1,2-二甲基-4-氧代-3-喹啉羧酸; 1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid CFN97215 73281-83-1 C12H11NO3 = 217.2 5mg QQ客服:2056216494

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