二氢柯楠因

Dihydrocorynantheine

	产品编号	CFN92844
	CAS编号	4684-43-9
	分子式 = 分子量	C₂₂H₂₈N₂O₃ = 368.5
	产品纯度	>=98%
	物理属性	Cryst.
	化合物类型	Alkaloids
	植物来源	The barks of Corynanthe pachyceras
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
二氢柯楠因	CFN92844	4684-43-9	1mg	QQ客服：3257982914
二氢柯楠因	CFN92844	4684-43-9	5mg	QQ客服：3257982914
二氢柯楠因	CFN92844	4684-43-9	10mg	QQ客服：3257982914
二氢柯楠因	CFN92844	4684-43-9	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Bordeaux (France)

Institute of Tropical Disease Universitas Airlangga (Indonesia)

University of Illinois at Chicago (USA)

University of Beira Interior (Portugal)

Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

Vin?a Institute of Nuclear Sciences (Serbia)

Kazusa DNA Research Institute (Japan)

Universidad de Buenos Aires (Argentina)

University of Mysore (India)

Cornell University (USA)

Worcester Polytechnic Institute (USA)

Aveiro University (Portugal)

China Medical University (Taiwan)

Universitas islam negeri Jakarta (Indonesia)

More...

Description:

Dihydrocorynantheine shows pronounced activity against Leishmania major promastigotes (IC50 at the micromolar level) but no significant in vitro antiplasmodial activity (against chloroquinesensitive Plasmodium falciparum). Dihydrocorynantheine exhibits significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC(50) = 6.73 μg/mL), it also shows weak inhibitory action on KCl-induced contraction.

Targets:

Antifection

In vitro:

Planta Medica, 2014 , 66 (6) :531-6.

Leishmanicidal, Antiplasmodial and Cytotoxic Activity of Indole Alkaloids from Corynanthe pachyceras.[Reference: WebLink]

Five indole alkaloids, corynantheidine, corynantheine, Dihydrocorynantheine, -yohimbine and corynanthine were isolated from bark of Corynanthe pachyceras K. Schum. (Rubiaceae).
METHODS AND RESULTS:
The structures were established by spectroscopic methods, inlcuding previously unreported assignment of all 1 HNMR resonances by COSY and NOESY experiments. These and related alkaloids showed pronounced activity against Leishmania major promastigotes (IC50 at the micromolar level) but no significant in vitro antiplasmodial activity (against chloroquinesensitive Plasmodium falciparum).
CONCLUSIONS:
Cytotoxicity assessed with drug sensitive KB-3-1 and multidrug-resistant KB-V1 cell lines was low; the alkaloids are apparently not substrates for the Pglycoprotein (P-170) efflux pump.

J Nat Prod. 2011 Jan 28;74(1):12-5.

Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla.[Pubmed: 21070010 ]

METHODS AND RESULTS:
An unusual oxindole alkaloid inner salt, macrophyllionium (1), and a pair of new tetracyclic oxindole alkaloids, macrophyllines A (2) and B (3), together with six known alkaloids, were isolated from the aerial parts of Uncaria macrophylla.
CONCLUSIONS:
Corynantheidine (8) exhibited moderate cytotoxicity against HL-60 and SW480 cells with IC(50) values of 13.96 and 23.28 μM, respectively. Dihydrocorynantheine (9) exhibited significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC(50) = 6.73 μg/mL). In addition, compounds 2, 6, and 9 showed weak inhibitory action on KCl-induced contraction.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
异钩藤碱酸; Isorhynchophyllic acid	CFN98132	144525-05-3	C₂₁H₂₆N₂O₄ = 370.44	5mg	QQ客服：1457312923
柯诺辛, 钩藤碱; Corynoxine	CFN90218	6877-32-3	C₂₂H₂₈N₂O₄ = 384.47	20mg	QQ客服：1457312923
异钩藤碱; Isorhyncophylline	CFN92553	6859-01-4	C₂₂H₂₈N₂O₄ = 384.5	20mg	QQ客服：1457312923
钩藤碱; Rhynchophylline	CFN98131	76-66-4	C₂₂H₂₈N₂O₄ = 384.47	20mg	QQ客服：1457312923
去氢钩藤碱; Corynoxeine	CFN98154	630-94-4	C₂₂H₂₆N₂O₄ = 382.45	20mg	QQ客服：215959384
异去氢钩藤碱; Isocorynoxeine	CFN98155	51014-29-0	C₂₂H₂₆N₂O₄ = 382.45	20mg	QQ客服：1413575084
二氢柯楠因; Dihydrocorynantheine	CFN92844	4684-43-9	C₂₂H₂₈N₂O₃ = 368.5	5mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7137 mL	13.5685 mL	27.137 mL	54.2741 mL	67.8426 mL
5 mM	0.5427 mL	2.7137 mL	5.4274 mL	10.8548 mL	13.5685 mL
10 mM	0.2714 mL	1.3569 mL	2.7137 mL	5.4274 mL	6.7843 mL
50 mM	0.0543 mL	0.2714 mL	0.5427 mL	1.0855 mL	1.3569 mL
100 mM	0.0271 mL	0.1357 mL	0.2714 mL	0.5427 mL	0.6784 mL